Application: Owing to their plasmonic properties nanoparticles of gold and silver find broad range of applications extending from diagnostics to molecular detection, photothermal and microwave-based therapies, and nanotoxicology. Colloidal silver nanoparticles also find applications in…

Synonym(s): PAK Inhibitor III, 1,1'-Disulfanediylbis(naphthalen-2-ol) Formula: C20H14O2S2 Formula weight: 350.50 CAS Number: 42521-82-4 UN Number: UN3077 Hazard Class: 9 Packing Group: III Harmonized Tariff Code:  2930.90 Risk Phrases: 41-50/53 Risk of serious damage to…

ICI 192605 is a potent antagonist of the thromboxane A₂ receptor (TP) that blocks contraction of isolated guinea pig trachea induced by U-46619 (Item No. 16450; K_d = 0.398 nM). It is used to study the role of TP signaling in tissues and animals.

A selective, orally available inhibitor of MEK1 (IC₅₀ = 4.2 nM); induces differentiation and apoptosis in cancer cells lines.

Synonym(s): 4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt; Eplivanserin hemifumarate salt; SR-46349B Empirical Formula: C₁₉H₂₁FN₂O₂ -+ 0.5 C₄H₄O₄ Linear Formula: …

A cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC₅₀ = 15 μM); inhibits clathrin-dependent vesicle formation and endocytosis; can also augment the release of neurotransmitters and secreted cytokines.

Synonym(s): (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide; 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Empirical Formula: C₁₈H₁₅Cl₄N₃OS Linear…

Synonym(s): Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate Empirical Formula: C₁₆H₁₁Cl₃F₃N₃O₃ Linear Formula: …

An orally bioavailable Smac/DIABLO mimetic and antagonist of IAPs (Kis = 66.4, 1.9, and 5.1 nM for XIAP, cIAP1, and cIAP2, respectively); inhibits cancer cell growth in various human cancer cell lines and induces apoptosis in xenograft tumors in mice.

Synonym(s): 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-benzamide dihydrochloride; PF 429242 dihydrochloride Empirical Formula: C₂₅H₃₅N₃O₂ -+ 2HCl Linear Formula: …

Synonym(s): 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid Empirical Formula: C₁₇H₁₅ClO₂ Linear Formula: C₁₇H₁₅ClO₂ Formula Weight: 286.75 MDL Number: MFCD17215962 Purity: ≥98% (HPLC) Storage: 2-8°C

A cell-permeable non-steroidal antagonist of GPER, inhibiting activation by either 17β-estradiol or the GPER-selective agonist G-1 (IC₅₀ = 112 and 165 nM, respectively); has no detectable binding activity to either ERα or ERβ.

A partial CB receptor agonist isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases; demonstrates selectivity for the peripheral CB2 receptor subtype (EC₅₀ = 3.28 μM; Ki = 1.44…

An non-nucleoside reverse transcriptase inhibitor that prevents RNA plus-strand initiation (IC₅₀ = 17 nM); also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing.

Synonym(s): α-[2-(4-Methoxyphenyl)-2-oxo-1-[(3,4,5-trimethoxyphenyl)methyl]ethylidene]-1,3-benzodioxole-5-acetic acid sodium salt Empirical Formula: C₂₈H₂₅O₉-+Na Linear Formula: C₂₈H₂₅O₉-+Na Formula Weight: 528.48 …

CAS Number: 64005-90-9 CAS Number: Empirical Formula (Hill Notation) C₂₂H₁₈N₂O₈ Molecular Weight: 438.39 MDL Number: MFCD00333607 PiB is an inhibitor of the peptidylprolyl isomerase Pin-1. Inhibition of Pin-1 leads to…

An NSAID that reduces edema in certain types of acute inflammation in animal models; a poor inhibitor of prostaglandin synthesis, but, like other NSAIDs, it inhibits OAT1 (Ki = 32 µM).

G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM. Competitive binding studies in endoplasmic reticulum α- (ERα-) and ERβ-expressing cells yielded Ki values for estradiol of 0.30 and 0.38 nM, respectively, with no substantial…

Synonym(s): N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methyl-propanamide Empirical Formula: C₂₉H₃₂F₂N₂O₂ Linear Formula: C₂₉H₃₂F₂N₂O₂ Formula…

A natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol; has anticancer agent activity as an angiogenesis inhibitor via the HIF-1α pathway; levels are significantly lower in women with severe pre-eclampsia.

An orally available, selective inhibitor of LSD1 (IC₅₀ < 20 nM); targets AML stem cells.