A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 =…

=99% (HPLC and TLC), BioXtra, for molecular biology Synonym: ?,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid ?-lactone, Ascotoxin, BFA, Cyanein, Decumbin CAS Number 20350-15-6 Empirical Formula (Hill Notation) C16H24O4 Molecular Weight 280.36 Beilstein…

Brefeldin A is a fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. Produced by Penicillium brefeldianum. Blocks binding of the cytosolic coat protein b-COP and ARF to Golgi membranes mediated by protein G. Also blocks protein transportation into…