A cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments; blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.

Cell permeable mycotoxin. Actin polymerization inhibitor. Binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. Induces nuclear extrusion. By disrupting actin polymerization, blocks diverse cellular functions, including cell division, migration,…

Synonym(s): Phomin Formula: C29H37NO5 Formula weight: 479.61 CAS Number: 14930-96-2 UN Number: UN1544 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2934.99 Hazard Statements: H300-H310-H330-H361 Fatal if swallowed. Fatal in contact with skin. Fatal if…

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport. One of a group of fungal metabolites that interfere with a wide…