50 mg, Cayman Chemical
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ML-204
Cayman ChemicalML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1,…
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LY2157299
Cayman ChemicalA small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM) that has been used to study the role of TGF-β signaling in triple negative breast cancer cells and hepatocellular carcinoma cells.
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Pyridoxal isonicotinoyl hydrazone
Cayman ChemicalA lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and also in vivo in rats and mice.
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Luzindole
Cayman ChemicalA melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values = 10-27 and 158-513 nM, respectively); used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways.
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Aztreonam
Cayman ChemicalA monobactam antibiotic that is effective against Gram-negative bacteria but inactive against Gram-positive bacteria.
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Fulvestrant
Cayman ChemicalA potent ER antagonist that works by both down-regulating and degrading ERα; efficacious in the treatment of estrogen-sensitive breast cancer; fully activates ER on hippocampal neurons.
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Cyclic Pifithrin-a (hydrobromide)
Cayman ChemicalA stable analog of PFT-α, formed by the condensation of PFT-α in solution; inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 μM, respectively); induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to…
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AEBSF (hydrochloride)
Cayman ChemicalA water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins; also inhibits NADPH oxidase.
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Linolein Hydroperoxides
Cayman ChemicalLinolein hydroperoxides are a mixture of 132 possible isomers of mono-, di-, and tri-hydroperoxides produced from the autoxidation of trilinolein. Autoxidation of linoleic acid containing triglycerides (for example, trilinolein) in vivo could result in the formation of these hydroperoxides. Unlike…
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Streptozotocin
Cayman ChemicalA glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA, leading to the destruction of beta cells.
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3-Methyladenine
Cayman ChemicalA specific inhibitor of PI3K activity and a widely used inhibitor of the autophagy; at 5 mM, inhibits protein degradation in rat hepatocytes by 65% and blocks class I, II, and III PI3Ks, including some downstream targets.
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BCTC
Cayman ChemicalA potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.
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Oleoyl Serotonin
Cayman ChemicalA hybrid molecule patterned after N-arachidonoyl serotonin; inhibits capsaicin-induced TRPV1 channel activation (IC50 = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
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O-Acetyl Salicylhydroxamic Acid
Cayman ChemicalO-ASHA is an irreversible, non-selective inhibitor of COX-1 and COX-2. Aspirin is the best-studied example of an irreversible COX inhibitor, acting via the acetylation of the active site serine residue 529 in human COX-1. O-ASHA inhibits ovine COX-1 in a time-dependent, irreversible manner with a…
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Fidaxomycin
Cayman ChemicalA natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively); has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive…
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Zoniporide (hydrochloride)
Cayman ChemicalSelectively inhibits human NHE-1 with an IC50 value of 14 nM; reduces infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.
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TTP 22
Cayman ChemicalTTP 22 is a thienopyrimidine compound that inhibits casein kinase 2 (CK2) with an IC50 value of 100 nM (Ki = 40 nM). It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.
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2,7-Dichlorodihydrofluorescein diacetate
Cayman ChemicalA fluorescent indicator of peroxynitrite formation; neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.
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1-Oleoyl Lysophosphatidic Acid (sodium salt)
Cayman Chemical1-Oleoyl lysophosphatidic acid is a species of LPA containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase.{2656}…
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2-(hydroxymethyl)-Pyrimidine
Cayman Chemical2-(hydroxymethyl)-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.
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Atorvastatin (calcium salt)
Cayman ChemicalAn HMG-CoA reductase inhibitor that is effective in treating hypercholesterolemia and certain dyslipidemias; reduces the production of LDL as well as inhibiting cholesterol synthesis; metabolized by CYP3A4, prodrug several metabolites that are important in the therapeutic actions attributed to atorvastatin.
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Pirfenidone
Cayman ChemicalAn orally active small molecule drug with antioxidant, anti-inflammatory, and anti-fibrotic effects; reduces inflammatory cytokine production, suppresses TGF-β expression, and lowers markers of oxidative stress; has effectiveness in IPF and other conditions with a significant fibrotic component.
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Genipin
Cayman ChemicalA protein cross-linking agent isolated from G. jasminoides Ellis; inhibits UCP2 activity; 5 µM genipin increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose; induces apoptosis in FaO rat hepatoma cells and human…
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(±)-Clopidogrel (hydrochloride)
Cayman ChemicalAn antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM); inhibits ADP-induced platelet aggregation ex vivo; shown to be beneficial in the prevention of vascular ischemic events for patients without…
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N1-Acetylspermine (hydrochloride)
Cayman ChemicalA monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.
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ß-Elemene
Cayman ChemicalA natural sesquiterpene that inhibits the proliferation of a wide range of tumors and enhances the effects of various chemotherapies; 10-40 µg/ml dose-dependently induces apoptosis and cell cycle arrest in the G2/M phase in HepG2 cells, upregulating Fas/FasL expression.
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3,4',5-Trismethoxybenzophenone
Cayman ChemicalAn analog of trimethoxy resveratrol; inhibits the growth of a variety of human tumor cell lines at concentrations form 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol
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Carfilzomib
Cayman ChemicalAn irreversible inhibitor of the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases; induces cell cycle arrest and…
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Hydroxychloroquine (sulfate)
Cayman ChemicalA synthetic quinine derivative commonly used as an anti-malarial drug; also useful in managing SLE, rheumatoid arthritis, and other diseases; inhibits autophagy and induces autophagic cell death (IC50 = 30 µM).
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Trametinib
Cayman ChemicalA potent inhibitor of both MEK 1 and 2 that works in an ATP-noncompetitive fashion (IC50s = 0.7 and 0.9 nM, respectively); blocks dual phosphorylation of ERK1/2 and stops cell cycling in cancer cell lines, both in vitro and in multiple tumor models in mice.
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Formoterol (hemifumarate)
Cayman ChemicalAn agonist of β-adrenergic receptors that activates the β1, β2, and β3 receptors with pEC50 values of 7.5, 9.0, and 6.8 respectively; displays high selectivity for β-adrenoceptors in the trachea over those in atria; activity is retained in the airway for extended periods.