Anti-Chicken IgG antibody is suitable for ELISA, western blot, and immunohistochemistry, as well as other assays requiring lot-to-lot consistency.

A selective NMDA receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors; widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.

An irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis; displays antiangiogenic, cytostatic, and antiparasitic effects.

Keystone essential fatty acid that is converted by COX, LO, and epoxygenase enzymes into more than 150 potent metabolites in species ranging from fungi to plants to mammals.

Synonyms: N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13,16,19-hexaoxadocos-21-ynamide; Crosslinker-E3 Ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader Molecular Formula: C29H37N3O11 …

A non-protein amino acid that chelates iron and copper; inhibits certain enzymes that contain iron or copper, including arginase (IC₅₀ = 3.7 µM).

A potent inhibitor of both MEK 1 and 2 that works in an ATP-noncompetitive fashion (IC₅₀s = 0.7 and 0.9 nM, respectively); blocks dual phosphorylation of ERK1/2 and stops cell cycling in cancer cell lines, both in vitro and in multiple tumor models in mice.

A prodrug for A-771726 that regulates T lymphocyte progression through the cell cycle by selectively inhibiting de novo pyrimidine synthesis; used to slow the disease progression of rheumatoid arthritis and as an immunosuppressive agent to prevent rejection of transplant allografts and xenografts.

A potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53); has been used in cells and in animals.

A synthetic H2S donor that can be readily esterified with other moieties, including therapeutics and targeting motifs; used both in cells and in animals for comparative studies with derived chimeras.

Hydroxy linoleins are a mixture of 132 possible isomers of mono-, di-, and tri-hydroxy compounds produced by the autoxidation of trilinolein and subsequent reduction of the hydroperoxides. Autoxidation of linoleic acid containing triglycerides (i.e., trilinolein) in vivo could result in the…

Best known as a potent dual inhibitor of c-Src and Abl (IC50 = 1.2 and 1.0 nM, respectively); can be effective in regulating tumor growth and differentiation; also inhibits other members of the Src and TEC families and certain other kinases at nanomolar concentrations.

A nuclesoside analog that disrupts DNA synthesis in blood cells; effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.

A cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards Synonyms: 10-Deacetyl-7-epipaclitaxel; 7-epi-10-Deacetyltaxol Molecular…

Formula: C21H11NO5S Formula weight: 389.39 Purity: 95% CAS Number: 3326-32-7 Harmonized Tariff Code:  2932.20 Hazard Statements: H334-H317 May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Precautionary Statements: …

A selective slow off-rate inhibitor of Raf kinases (IC₅₀s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively); shows significant antiproliferative activity against mutated BRAF or mutated NRAS cancer cell lines and xenograft models.

A hybrid molecule of indomethacin and an NO donor which combines the anti-inflammatory properties of an NSAID with the gastrointestinal protective effects of NO.

A selective inhibitor of PI3Kγ

Synonym(s): (±)-Abscisic acid; (2 Z ,4 E )-5-(1-Hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl)-3-methyl-2,4-pentadienoic acid; ABA; Dormin Formula: C₁₅H₂₀O₄ Formula Weight: 264.32 CAS No.: 14375-45-2 Purity: 98% Storage: 2-8°C …

A colchicine derivative that inhibits tubulin polymerization (IC₅₀ = 2.1 μM) with low toxicity; suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase; used to synchronize cells and for karyotyping in cytogenetic studies.

Synonym(s): 2,6-Dihydroxy-7-methylpurine, Heteroxanthine Formula: C6H6N4O2 Formula weight: 166.14 Purity: 98% CAS Number: 552-62-5 Harmonized Tariff Code:  2933.59

Synonyms: Ethyl 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionate Formula: C₁₉H₁₇ClN₂O₄ Formula Weight: 372.80 CAS No.: 76578-14-8 Legal Information: PESTANAL is a registered trademark of Sigma-Aldrich Laborchemikalien GmbH

Synonym(s): TLCK, N^a-p-Tosyl-DL-lysine chloromethyl ketone hydrochloride Formula: C14H21ClN2O3S HCl Formula weight: 369.31 Purity: 98% CAS Number: 4238-41-9 Harmonized Tariff Code:  2935.00 Hazard Statements: H315-H319-H335 Causes skin irritation. Causes serious eye irritation.…

The major metabolite of the gastric proton pump inhibitor, omeprazole; produced by CYP3A4 sulfoxidation of esomeprazole.

Empirical Formula: C₃₄H₆₃N₅O₉ Linear Formula: C₃₄H₆₃N₅O₉ Formula Weight: 685.89 MDL Number: MFCD00060740 Melting Point: 233 °C (dec.)(lit.) Storage: 2-8°C Beilstein Registry…

A salen-manganese complex with catalase and SOD mimetic activity.

Synonyms: Sulfo-KMUS Purity Limit: 99% CAS No.: 211236-68-9 Molecular Formula: C19H25N2O9SNa Molecular Weight: 485.47 MDL No.: MFCD01075057 Melting Point: 245 °C (Decomp) Storage Temperature: Store at 0-8°C

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards Synonyms: Pantoprazole sulfone;…

An inhibitor of HIF-1α protein translation; suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase; cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25 µM.

An inhibitor of CETP; inhibits plasma CETP with an IC₅₀ value of 9 µM; in rabbits given an atherogenic diet, increases HDL, decreases VLDL, and attenuates induced atherosclerosis; in humans, inhibits CETP activity and increases HDL levels but does not reduce the risk of recurrent…