Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1)…

Empirical Formula: C₅H₉NO₂ Linear Formula: C₅H₉NO₂ Formula Weight: 115.13 MDL Number: MFCD00166364 Storage: −20°C

Synonyms: Crosslinker-E3 Ligase ligand conjugate; Pomalidomide-2-2-2-2-2-2-6-N3, 24-azido-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15,18-hexaoxatetracosanamide; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader …

A non-nucleoside reverse transcriptase inhibitor that binds to viral reverse transcriptase and blocks polymerase activity by preventing RNA plus-strand initiation (IC₅₀s = ~ 0.45 to 0.9 μM).

A variety of natural products from plant sources, particularly flavonoids, have long been observed to have antioxidant activity with potential benefits for human health. Antioxidant triterpenes are less common. Celastrol is a triterpenoid antioxidant compound isolated from the Chinese thunder god…

An antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC₅₀ = 100 nM); inhibits ADP-induced platelet aggregation ex vivo; shown to be beneficial in the prevention of vascular ischemic events for patients without…

A dietary flavonoid which has diverse physiological activities through both direct and indirect effects; directly binds ERα and ERβ, acting as an inverse agonist or agonist; acts as an antioxidant; suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.

A nuclesoside analog that disrupts DNA synthesis in blood cells; effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.

Mn(III)TMPyP is a cell-permeable SOD mimic and peroxynitrite decomposition catalyst. The rate constants for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M−1s−1 and ~2 x 106 M−1s−1, respectively.

A non-ionic, water-soluble X-ray contrast agent for intravascular administration; can cause acute kidney injury and is used in animal models of contrast-induced nephropathy.

CAS No.: 99-50-3 Synonyms: Protocatechuic acid Formula: C₇H₆O₄ Formula Weight: 154.12 Linear Formula: (HO)₂C₆H₃CO₂H MDL No.: MFCD00002509 Purity: ≥97.0% (HPLC) Melting Point: …

A natural polymethoxylated flavonoid and potent antioxidant with good bioavailability; has anti-inflammatory effects that are relevant to a host of diseases, including cancer, arthritis, and neurodegeneration; inhibits P-glycoprotein and BCRP (IC₅₀ = 11.5 and 4.9 μM, respectively).

A potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.

Synonym: N -(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozotocin CAS Number: 18883-66-4 Empirical Formula (Hill Notation): C₈H₁₅N₃O₇ Molecular Weight: 265.22 Beilstein Registry Number: 2060675 EC Number: …

Synonym(s): 4- O -(3,4-Dihydroxycinnamoyl)-D-quinic acid; Cryptochlorogenic acid Empirical Formula: C₁₆H₁₈O₉ Linear Formula: C₁₆H₁₈O₉ Formula Weight: 354.31 MDL Number: MFCD10566638 Purity: ≥98.0% Storage: 2-8°C

An imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells; rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.

Pyrantel Impurity B is an impurity of the broad-spectrum anthelminthic drug, pyrantel. Pyrantel is a medication, commonly indicated for the treatment of intestinal nematodes. Its mode of action involves the interference with ganglionic neurotransmission via blocking of the acetylcholine receptors…

A potent and selective CB1 receptor inverse agonist (Ki = 243 nM; EC50 = 195 nM); a 10 µM concentration results in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and CB2 receptors, respectively.

HOOK™ PFP-Biotin reacts with protein primary amines.Amines, lysine ε-amines and N-terminal α-amines, are the most abundant group in protein molecules and represent the most common target for biotinylation. For example, BSA contains 59 primary amines, of which up to 35 are…

1-Oleoyl lysophosphatidic acid is a species of LPA containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase.{2656}…

Anti-Guinea Pig IgG F(ab')2 antibody is suitable for ELISA, western blot, and immunohistochemistry, as well as other assays requiring lot-to-lot consistency.

A highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC₅₀ = 29 pM); rapidly suppresses autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells.

A selective inhibitor of PFKFB3 (IC₅₀ = 207 nM); rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice.

An intermediary prodrug of fluorouracil, the pyrimidine analog that inhibits thymidylate synthase selectively in tumor cells, interfering with DNA synthesis; one of two intermediary metabolites formed during metabolic conversion of the chemotherapeutic prodrug, capecitabine, to fluorouracil.

Carboxy-PTIO is a NO scavenger. It reacts stoichiometrically with NO and can be used for EPR detection of NO.

Synonym(s): 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride Empirical Formula: C₁₉H₂₀N₂O₃S -+ HCl Linear Formula: C₁₉H₂₀N₂O₃S -+ HCl Formula Weight: 392.90 …

A natural product with anti-inflammatory, anti-tumor, and neuroprotective effects; inhibits GSK-3 (IC₅₀ = 2.5 μM) and Cdk1 and 5 (IC₅₀ = 10 μM for both isoforms).

Synonym(s): 3,4',5,7-Tetrahydroxyflavone Formula: C15H10O6 Formula weight: 286.24 Purity: 98+% CAS Number: 520-18-3 Harmonized Tariff Code:  2932.99 Hazard Statements: H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. …

A dual inhibitor of c-Src and Abl (IC50 = 2.7 and 30 nM, respectively); less effectively inhibits other kinases; blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival; reduces osteoclast bone resorption.

An inhibitor of Ras-mediated signaling that inhibits the growth of PANC-1 and U87 tumor cells with IC₅₀ values of 20 and 10 µM, respectively.

Synonyms: PLGA near IR; PLGA-FPI749; near IR conjugated PLGA Linear Structural Formula: (C3H4O2)x(C2H2O2)y Storage: -20C Application: Poly(lactide-co-glycolide)-Flamma Fluor near-IR is labelled with Flamma Fluor FPI749 near-IR dye. It can be used in the formation of fluoresent…

A form of the myristic acid that is found in the lipid A component of some Gram negative bacteria, including Escherichia, Haemophilus, Actinobacillus, and Campylobacter species.