1 g, NEW! Life Science
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4-Methylumbelliferyl-ß-D-Glucuronide (hydrate)
Cayman ChemicalA fluorogenic substrate of β-glucuronidase that upon cleavage yields a blue fluorescent end product that can be monitored by UV light; typically used in the GUS reporter system for fluorescent detection of β-glucuronidase gene expression in E. coli and transformed plants.
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Hygromycin B
Cayman ChemicalAn antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.
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Tamoxifen
Cayman ChemicalA selective estrogen receptor (ER) modulator; an ER antagonist in breast tissue, effective in treating early breast cancer; an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues.
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Isoprinosine
Cayman ChemicalA complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio; has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production; shows antiviral activity.
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Vancomycin (hydrochloride)
Cayman ChemicalA glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci; binds to bacterial cell wall precursors, interfering with their synthesis.
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Griseofulvin
Cayman ChemicalA natural bacterial product used, in certain formulations, as an oral antibiotic for fungal infections of the skin; alters microtubule dynamics, resulting in metaphase arrest.
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IPTG
Agilent GenomicsDeploy IPTG in blue/white selection assays to detect ß-galactosidase activity Used in combination with X-gal to detect ß-galactosidase activity in blue/white selection assays. Can induce protein expression when used with a number of derivatives including DE3-derivatives and…
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Bupivacaine
Cayman ChemicalAn amino-amide anesthetic that binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, preventing the generation of an action potential; inhibits the uptake of dopamine in striatal synaptosomes by 47% at 100 µM.
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Taurocholic Acid (sodium salt)
Cayman ChemicalA bile salt formed in the liver by conjugation of cholic acid with taurine that can be used to solubilize lipids and membrane-bound proteins.
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Tamoxifen (citrate)
Cayman ChemicalA selective estrogen receptor (ER) modulator used as adjuvant therapy for estrogen-dependent breast cancer; increases ER activity in bone, uterus, and the cardiovasculature system as it decreases ER activity in breast tissues; metabolized by CYP450 enzymes to active metabolites; alters cholesterol…
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Doxazosin (mesylate)
Cayman ChemicalA non-selective α-adrenergic receptor antagonist with pKi values of 8.5, 9, and 8.4 for human α1A, α1B, and α1D adrenoceptors, respectively; used to relax smooth muscles of the prostate in clinical studies designed to examine treatments that improve lower urinary tract…
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X-Gal
Cayman ChemicalA cell-permeable, chromogenic substrate for β-galactosidase used in histochemical and molecular biology applications, including detection of lacZ activity in cells and tissues.
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Ceftazidime (hydrate)
Cayman ChemicalA broad-spectrum β-lactam antibiotic used for parenteral administration.
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Melatonin
MP BiomedicalsMelatonin is a hormone of the pineal gland. Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell…
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N-Octyl-ß-D-thioglucopyranoside
Cayman ChemicalA low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.
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L-Glutathione, reduced
Cayman ChemicalGSH is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of…
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TCEP (hydrochloride)
Cayman ChemicalAn odorless, selective, and water-soluble reducing agent that is commonly used in many laboratory applications; commonly used to rapidly reduce protein and peptide disulfide bonds.
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1-thio-ß-D-Glucose (sodium salt)
Cayman ChemicalAn analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position, allowing diverse chemical reactions, including click chemistry and polymerization; can be labeled with technetium-99m for analytical and diagnostic procedures.
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Sodium Hydrogen Sulfide (hydrate)
Cayman ChemicalAn H2S donor commonly used in cellular and whole animal experimental systems.
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Corticosterone
Cayman ChemicalA steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors; also is the precursor to aldosterone synthesis.
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2-Hydroxypropyl-ß-cyclodextrin
Cayman ChemicalA cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.
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3,4,6-Tri-O-benzyl-ß-D-Mannopyranose 1,2-(methyl orthoacetate)
Cayman ChemicalA synthetic intermediate used in glycosylation reactions.
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D-Luciferin (potassium salt)
Cayman ChemicalA chemiluminescent substrate of firefly luciferase which produces light upon oxidative decarboxylation in the presence of ATP.
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Ketoconazole
Cayman ChemicalAn orally active broad spectrum antifungal agent that blocks ergosterol biosynthesis by inhibiting the fungal CYP isoform CYP51; potently inhibits the mammalian analog CYP51A1 (IC50 = 63.5 nM), as well as a variety of other CYP isoforms.
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Xylazine
Cayman ChemicalAn agonist of α2 adrenergic receptors (Ki = 194 nM); used for sedation, anesthesia, and analgesia in non-human mammals.
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DL-a-Lipoic Acid
Cayman ChemicalDL-α-lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.{12280,12281,12322} DL-α-lipoic acid can act as a direct radical…
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Fluconazole
Cayman ChemicalA triazole antifungal agent that is effective against most Candida strains.
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Trolox
Cayman ChemicalA cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties; commonly used as a standard or positive control in antioxidant assays.
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Kynurenic Acid
Cayman ChemicalA metabolite of tryptophan that has pronounced effects on neuronal signaling; broadly antagonizes ionotopic glutamate receptors; has potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 µM), GPR35 (EC50 = 39 µM), aryl hydrocarbon receptor (EC50 = 300…
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Vitamin D2
Cayman ChemicalProduced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation; metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2.
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Polymyxin B (sulfate)
Cayman ChemicalA mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components; demonstrates rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumonia.
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Amphotericin B
Cayman ChemicalA polyene macrolide used in the treatment of infections caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures; binds with ergosterol in fungal cell membranes, altering membrane permeability and ultimately…