1 g, NEW! Life Science
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NADP+ (sodium salt hydrate)
Cayman ChemicalThe oxidized form of NADPH; serves as a cofactor in various biological reactions.
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Novobiocin (sodium salt)
Cayman ChemicalA coumarin antibiotic that inhibits the ATPase activity of DNA gyrase, permitting relaxation of negative supercoils; also generates positively supercoiled DNA.
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Taurocholic Acid (sodium salt)
Cayman ChemicalA bile salt formed in the liver by conjugation of cholic acid with taurine that can be used to solubilize lipids and membrane-bound proteins.
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SAHA
Cayman ChemicalAn HDAC inhibitor of class I and class II HDACs at around 50 nM; arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.
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Amlodipine
Cayman ChemicalA dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle; inhibits calcium-induced contractions in depolarized rat aorta (IC50 = 1.9 nM), displaying a slow rate of association and dissociation in isolated vascular and…
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Tamoxifen
Cayman ChemicalA selective estrogen receptor (ER) modulator; an ER antagonist in breast tissue, effective in treating early breast cancer; an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues.
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Ceftazidime (hydrate)
Cayman ChemicalA broad-spectrum β-lactam antibiotic used for parenteral administration.
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Amiodarone (hydrochloride)
Cayman ChemicalA class III antiarrhythmic agent; inhibits KCNH2 with an IC50 value of 1 µM; also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.
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10-HDA
Cayman ChemicalAn unsaturated fatty acid found in royal jelly produced from honeybees; demonstrates longevity-promoting effects in C. elegans, down regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis, inhibits VEGF-induced angiogenesis in HUVECs, facilitates differentiation of neurons from neural…
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Nicotine Bitartrate Dihydrate
MP BiomedicalsNicotinic acetylcholine receptor agonist isolated from Nicotiana tabacum and Nicotiana rustica. Nicotine Tartrate finds an application as the nicotine active in a wide range of smoking cessation products such as nicotine lozenges and nicotine sub-lingual tablets. (-)-Nicotine ditartrate is a…
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Doxepin (hydrochloride)
Cayman ChemicalA tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.
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Lenalidomide
Cayman ChemicalAn analog of thalidomide that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines; induces proliferation and enhances the functional capacity of T-lymphocytes, amplifying co-stimulatory signaling pathways.
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Amylose
Cayman ChemicalA polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.
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Doxazosin (mesylate)
Cayman ChemicalA non-selective α-adrenergic receptor antagonist with pKi values of 8.5, 9, and 8.4 for human α1A, α1B, and α1D adrenoceptors, respectively; used to relax smooth muscles of the prostate in clinical studies designed to examine treatments that improve lower urinary tract…
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Vitamin D2
Cayman ChemicalProduced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation; metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2.
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2-cyano-Pyrimidine
Cayman ChemicalCathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and derivatives are being studied for the treatment of osteoporosis.…
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D-Luciferin (potassium salt)
Cayman ChemicalA chemiluminescent substrate of firefly luciferase which produces light upon oxidative decarboxylation in the presence of ATP.
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Nitro Blue Tetrazolium (chloride)
Cayman ChemicalA chromogenic substrate that, like other tetrazolium compounds, can be reduced to produce a colored formazan derivative; used in the “NBT test” to evaluate the activity of NADPH oxidase in phagocytes; paired with PCIB for the colorimetric detection of alkaline phosphatase activity.
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Tianeptine (sodium salt)
Cayman ChemicalAn atypical antidepressant with diverse actions, most notably on the glutamatergic system; attenuates glutamate release and modulates the function of AMPAR; acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641 nM for human and mouse receptors, respectively).
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Isovaleroylglycine
Cayman ChemicalUrinary metabolite of leucine that is used as a diagnostic tool in the diagnosis of various acidemias and mitochondrial fatty acid β-oxidation defects.
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L-Citrulline
LKT LabsL-Citrulline is a by product of NO formation from metabolism of L-arginine that exhibits tocolytic and antioxidative activities. L-Citrulline was originally found in watermelon. In isolated rat uteri, L-citrulline decreases uterine contractile force through stimulation of the NO-cGMP relaxant…
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(+)-Catechin (hydrate)
Cayman ChemicalCatechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid…
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Vildagliptin
Cayman ChemicalAn inhibitor of DPP-4 (IC50 = 3.5-34 nM); also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or FAPα; blocks the degradation of several circulating peptides, including incretins; reduces fasting and postprandial glucose levels and decreases inflammatory…
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Boldine
Cayman ChemicalAn aporphine alkaloid that possesses antioxidant and free-radical scavenging ability and has been linked to anti-inflammatory, anti-pyretic, anti-diabetic, anti-atherogenic, anti-platelet, anti-tumor, UV-protective, and hepatoprotective effects.
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L-Glutathione, reduced
Cayman ChemicalGSH is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of…
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Nisin A
Cayman ChemicalA bacteriocin, a natural polycyclic antibacterial peptide, also called a lantibiotic; particularly effective against Gram-positive bacteria and commonly used as a food preservative.
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1,6-Anhydro-ß-D-mannopyranose
Cayman ChemicalA major organic tracer generated by burned cellulose; used to evaluate, in atmospheric samples, the burning of wood.
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EGS, 1 g
bioWORLDEthylene glycol bis-(succinimidylsuccinate) Long reach and cleavable under gentle conditions Category: Amine-reactive Reactive Groups: NHS-esters Reactive Toward: amino groups Water soluble: No Membrane Permeable: Yes Cleavability: Cleavable Cleavable By: Hydroxylamine…
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Stigmasterol
Cayman ChemicalA natural plant sterol that can be isolated from certain seed oils and herbs, including those used for therapeutic purposes.
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Aceclofenac
LKT LabsAceclofenac is a diclofenac analog that exhibits anti-inflammatory and analgesic activities. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that somewhat selectively inhibits COX-2; it is clinically used to treat rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.…
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Acetyl-L-Carnitine Hydrochloride
LKT LabsAcetyl-L-carnitine is a derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65,…