100 mg, Cayman Chemical
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Aztreonam
Cayman ChemicalA monobactam antibiotic that is effective against Gram-negative bacteria but inactive against Gram-positive bacteria.
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AEBSF (hydrochloride)
Cayman ChemicalA water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins; also inhibits NADPH oxidase.
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Streptozotocin
Cayman ChemicalA glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA, leading to the destruction of beta cells.
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3-Methyladenine
Cayman ChemicalA specific inhibitor of PI3K activity and a widely used inhibitor of the autophagy; at 5 mM, inhibits protein degradation in rat hepatocytes by 65% and blocks class I, II, and III PI3Ks, including some downstream targets.
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Diazoxide
Cayman ChemicalA potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions; relaxes rat aorta rings (ED50 = 19.3 μM) and has been used as a vasodilator in the treatment of hypertensio
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Fidaxomycin
Cayman ChemicalA natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively); has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive…
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3,3'-Diindolylmethane
Cayman ChemicalPhytochemical from cruciferous vegetables that demonstrates anticancer and chemopreventative effects (10-30 µM) involving the induction of Phase 2 enzymes, promotion of apoptosis, induction of cell cycle arrest, inhibition of cell proliferation, and inhibition of histone deacetylases and DNA…
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2,7-Dichlorodihydrofluorescein diacetate
Cayman ChemicalA fluorescent indicator of peroxynitrite formation; neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.
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2-(hydroxymethyl)-Pyrimidine
Cayman Chemical2-(hydroxymethyl)-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.
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Thidiazuron
Cayman ChemicalA synthetic cytokinin used as a media supplement to regulate growth in woody plant tissue cultures and micropropagations; concentrations below 1 µM promote axillary proliferation, whereas concentrations above 1 µM can stimulate the formation of callus, adventitious shoots, or somatic embryos.
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Pirfenidone
Cayman ChemicalAn orally active small molecule drug with antioxidant, anti-inflammatory, and anti-fibrotic effects; reduces inflammatory cytokine production, suppresses TGF-β expression, and lowers markers of oxidative stress; has effectiveness in IPF and other conditions with a significant fibrotic component.
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Biotin-NHS
Cayman ChemicalA compound used to attach biotin to primary amines, such as lysines on the surface of proteins, under alkaline conditions (pH~8-9).
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all-trans Retinal
Cayman ChemicalA natural retinoid that associates with CRBP-I and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol; an intermediate of the phototransduction pathway of photoreceptors; can form toxic conjugates with proteins and lipids, leading to…
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a-Hydroxyglutaric Acid (sodium salt)
Cayman ChemicalAn α-hydroxy acid, overproduced in 2-hydroxyglutaric aciduria; mutations in IDH1 and IDH2 cause these enzymes to convert isocitrate to 2-hydroxyglutarate; competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.
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ß-Elemene
Cayman ChemicalA natural sesquiterpene that inhibits the proliferation of a wide range of tumors and enhances the effects of various chemotherapies; 10-40 µg/ml dose-dependently induces apoptosis and cell cycle arrest in the G2/M phase in HepG2 cells, upregulating Fas/FasL expression.
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3,4',5-Trismethoxybenzophenone
Cayman ChemicalAn analog of trimethoxy resveratrol; inhibits the growth of a variety of human tumor cell lines at concentrations form 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol
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Hydroxychloroquine (sulfate)
Cayman ChemicalA synthetic quinine derivative commonly used as an anti-malarial drug; also useful in managing SLE, rheumatoid arthritis, and other diseases; inhibits autophagy and induces autophagic cell death (IC50 = 30 µM).
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(R,S)-Anatabine
Cayman ChemicalA minor alkaloid produced in plants of the Solanaceae family, including tobacco; detection in urine is used as an indicator of tobacco use; diminishes Aβ production, reduces the transcription and protein levels of β-secretase, and dose dependently inhibits NF-κB activation.
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Carboxy-PTIO (potassium salt)
Cayman ChemicalCarboxy-PTIO is a NO scavenger. It reacts stoichiometrically with NO and can be used for EPR detection of NO.
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Guanosine 5'-triphosphate (sodium salt hydrate)
Cayman ChemicalA substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication; participates in G-protein-related signal transduction where it is converted to GDP through the action of GTPases.
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DL-Glyceraldehyde-3-phosphate
Cayman ChemicalAn intermediate in several metabolic pathways, including glycolysis and gluconeogenesis.
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Ganciclovir
Cayman ChemicalA synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections; inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.
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Mn(III)TBAP
Cayman ChemicalMn(III)TBAP is a cell-permeable SOD mimic. At a concentration of 30 µM, it decreases the doubling time of SOD-null E. coli. by 2-fold.
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Valsartan
Cayman ChemicalA nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (IC50 = 2.7 nM); does not alter PPARγ activity.
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Arctiin
Cayman ChemicalThe major active lignin in fruits of the burdock plant A. lappa that demonstrates potent antiviral, anti-inflammatory, and antiproliferative activity.
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PDMP (hydrochloride)
Cayman ChemicalA ceramide analog that contains a mixture of all four possible stereoisomers.
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ADT-OH
Cayman ChemicalA synthetic H2S donor that can be readily esterified with other moieties, including therapeutics and targeting motifs; used both in cells and in animals for comparative studies with derived chimeras.
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Solifenacin (succinate)
Cayman ChemicalA competitive antagonist of muscarinic receptors that potently blocks signaling through M1, M2, and M3 (Kis = 25, 125, and 10 nM, respectively), resulting in muscle relaxation.
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Doxazosin (mesylate)
Cayman ChemicalA non-selective α-adrenergic receptor antagonist with pKi values of 8.5, 9, and 8.4 for human α1A, α1B, and α1D adrenoceptors, respectively; used to relax smooth muscles of the prostate in clinical studies designed to examine treatments that improve lower urinary tract…
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L-Leucyl-L-Leucine methyl ester (hydrochloride)
Cayman ChemicalA lysosomal condensation product that selectively eliminates dipeptidyl peptidase I-expressing immune cells, including cytotoxic T cells and natural killer cells.
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Gaboxadol (hydrochloride)
Cayman ChemicalA GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)); acts as an antagonist…
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CAY10512
Cayman ChemicalCAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.