Hyaluronidase is a glycoprotein containing 5% mannose and 2.17% glucosamine, it catalyzes the random hydrolysis of 1,4-linkages between 2-acetamido- 2-deoxy- b-D-glucose and D-glucose residues in hyaluronate. Hyaluronidase from bovine testes is a tetramer consisting of 4 equal subunits with a…

Poly-lysine is a polycation which binds to DNA, red cell membrane and any negatively charged protein. It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. When…

Physiological chelating agent for heavy metals. It is used as an antirheumatic and as a chelating agent in Wilson′s disease. It is used as a copper chelator to form mixed disulfides with cysteine or other sulfide media components. It is used to inactivate protein-1 DNA binding and to…

β-NADP is a coenzyme necessary for the alcoholic fermentation of glucose and the oxidative dehydrogenation of other substances. It occurs widely in living tissue, especially in the liver. Nicotinic acid can be converted to nicotinamide in the body and, in this form, is found as a component of…

Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. It also belongs to the drug type plant alkaloid. The primary cytotoxic target for etoposide is topoisomerase II. This ubiquitous enzyme regulates DNA under- and overwinding, and removes knots…

Sodium phosphate monobasic is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. Useful in conjunction with Sodium Dibasic Phosphate, in the preparation of biological buffers. Used in many applications including the purification of antibodies.

Potassium phosphate is a reagent with high buffering capacity. It occurs in several forms: monobasic, dibasic, and tribasic (K3PO4). Most pH neutral potassium phosphate buffer solutions consist of mixtures of the monobasic and dibasic forms to varying degrees, depending on the desired pH. …

Potassium Iodide is known as Potassium Salt of Hydriodic Acid [HI], available in white crystalline powder form. It is a mild reducing agent and can be easily oxidized to Iodine by powerful oxidizing agent like chlorine. With elemental iodine it forms I3 (tri iodide), the salts of tri iodide are…

Collagenases degrade native helical collagen fibrils. Plays an important role in connective tissue metabolism Produced by specific cells involved in repairs and remodeling processes Type II enzyme that contains greater clostripain activity Collagenase is used for collagen…

Triton® X-100 is a alkylaryl polyether alcohol. It is a nonionic surfactant prepared by the reaction of octylphenol with ethylene oxide. The number ("-100") relates only indirectly to the number of ethylene oxide units in the structure. Triton X-100 is a non-ionic surfactant and…

β-2-microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. The interaction is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide…

β-NAD is one of the biologically active forms of nicotinic acid. Coenzyme of the dehydrogenases, especially in the dehydrogenation of primary and secondary alcohols Inhibitory neurotransmitter in visceral smooth muscle Acts as a hydrogen acceptor, forming NADH …

Lecithin is a purified, wax-like phosphatidylcholine of soybean origin. In addition to being the major structural component of cellular membranes, phosphatidylcholine serves as a reservoir for several lipid messengers, it is the source of the bioactive lipids lysophosphatidylcholine, phosphatidic…

Dimethyl sulfoxide is a dipolar, aprotic solvent. Has been shown to accelerate strand renaturation (1-10% concentration) and is believed to give the nucleic acid thermal stability against depurination. By heating the solid form to approximately 30°C, the product can be melted without harming…

Methionine is one of the common sulfur-containing amino acids. Methionine is a common methyl-group donor to various substrates, such as creatine, epinephrine, ergosterol, and choline. L-Methionine is used as an essential amino acid for human development and therapeutically acts as an antidote…

Zinc chloride is a widely used reagent in various industrial processes. These include textile finishing, the etching of metals, the manufacture of parchment paper, and the preparation of galvanizing, soldering, and tinning fluxes. Zinc chloride is also used in organic chemical synthesis, such as in…

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. It has no significant activity against other Gram-negative bacteria and very limited activity against Gram-positive bacteria and anaerobic bacteria. Cefuslodin is most…

Folic acid, also known as folate, is a B vitamin that can be found in a variety of fruits and vegetables. Can be chemically synthesized Water soluble Exhibits metal binding properties Folic acid (Vitamin B9 and folate) is essential to numerous bodily functions. The human body needs…

Suitable for cell adhesion in tissue culture, as well as gel formation, platelet aggregation, and as a substrate for collagenase. Collagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of vertebrates. It is the main component of…

Tamoxifen is a Protein Kinase C inhibitor. It induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in…

L-Glutamic Acid is a non-essential amino acid for human development; referred to as an excitatory amino acid (EAA) due to its role in neurotransmission. Acts as a neurotransmitter at fast synapses; agonist at kainate, NMDA and quisqualate receptors. L-Glutamic acid is one of the two amino acids…

Fluorescent Brightner 28 is a colorless organic compound that fluoresces (clear bluish) under ultraviolet radiation. It is related structurally to Fluorescent Brightner 9 (Calcofluor White MR) which was used by Jefferies and Belcher and Maeda and Ischida in plant tissue studies. Fluorescent…

Nicotinic acetylcholine receptor agonist isolated from Nicotiana tabacum and Nicotiana rustica. Nicotine Tartrate finds an application as the nicotine active in a wide range of smoking cessation products such as nicotine lozenges and nicotine sub-lingual tablets. (-)-Nicotine ditartrate is a…

Aldehyde dehydrogenase belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. Aldehyde dehydrogenase oxidizes a number of aliphatic and aromatic aldehydes. Acetyl-GSH is not hydrolyzed. Aldehyde…

Sodium metasilicate nonahydrate is white powder, mainly used in detergent/washing industry, metal cleaner and ceramic industry. In detergent/washing industry, it can be used instead of Sodium triphosphate to raise cleaning efficiency and reduce enviroment pollution, provide excellent alkaline…

Evans Blue is a potent inhibitor of L-glutamate uptake into synaptic vesicles via EAAT. Evans Blue also inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). The compound is also a P2X-selective purinoceptor antagonist. Evans Blue used in…

Deoxyribonuclease from beef pancreas, DNase I, was first crystallized by Kunitz. It is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3'. The…

Pancreatin is a digestive enzyme produced by the pancreas and delivered to the small intestine for the hydrolysis of complex nutrients. Pancreatin contains enzymatic components including trypsin, amylase and lipase, ribonuclease, and protease, produced by the exocrine cells of the porcine pancreas.…

β-Sitosterol is a common plant steroid that possesses anticholesteremic properties. β-Sitosterol has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.

Stearic acid is a long-chain saturated fatty acid that can be derived from either animal fats or vegetable oils. Compared to other long-chain saturated fatty acids that are hypercholesterolemic, experimental diets high in stearic acid (9.3-11.8% of energy) do not raise plasma total cholesterol or…

Guanosine-5'-triphosphate, a purine nucleotide, is required as a coenzyme for protein biosynthesis in a cell-free system. Guanosine 5′-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR)…

2,3,5-Triphenyltetrazolium Chloride is a redox indicator. In the TTC assay (also known as TTC test or tetrazolium test), TTC is used to differentiate between metabolically active and inactive tissues. The white compound is enzymatically reduced to red TPF (1,3,5-triphenylformazan) in living tissues…