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MP Biomedicals

Hyaluronidase from Bovine Testes

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Hyaluronidase is a glycoprotein containing 5% mannose and 2.17% glucosamine, it catalyzes the random hydrolysis of 1,4-linkages between 2-acetamido- 2-deoxy- b-D-glucose and D-glucose residues in hyaluronate. Hyaluronidase from bovine testes is a tetramer consisting of 4 equal subunits with a molecular mass of 14 kDa each.

Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B), primarily to tetrasaccharide residues. Monosaccharides are not liberated. Hyaluronidase is often used in conjunction with collagenase to dissociate the extracellular matrix between cells of animal tissue, in order to release viable cells for use in tissue culture. It may also be used to clarify synovial fluids in order to make cell counts possible.

Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

Specific Activity: ≥300 USP u/mg

Key Applications: Drug dispersion & delivery

Application Areas: Molecular Biology, Enzyme

Product Type: Proteins, Enzymes & Peptides

Gene Id: 281838

Gene Symbol & Aliases: HYAL1, HYAL2

Uniport Number: Q8SQG8

Extinction Coefficient (E1%): ~8 (lit.)

Presentation: Tan Powder

Format: Lyophilized powder form

pH: Optimum pH 4.5 - 6 (Lit.)

NOTES: Inhibitors: Fe2+ and Fe3+ are inhibitory as are Mn2+ and Cu2+, Sodium chloride acts as a stabilizer

Specificity: Testicular hyaluronidase hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid and chondroitin sulfuric acids A and C (but not B), primarily to tetrasaccharide residues. Monosaccharides are not liberated

Solubility: Dissolve 10 mg hyaluronic acid in 25 ml 0.1 M sodium phosphate buffer: pH 5.3 with 0.15 M sodium chloride

Storage & Handling: -20°C

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Product Detail
Thomas No.
C830L82
Mfr. No.
0210074080
CAS #
37326-33-3
Description
Hyaluronidase from Bovine Testes, 100mg
Packaging Size
100 mg
Packaging Type
Bottle, Glass, Amber
list price/quantitytotal
$0.00
Thomas No.
C830L83
Mfr. No.
0210074090
CAS #
37326-33-3
Description
Hyaluronidase from Bovine Testes, 500mg
Packaging Size
500 mg
Packaging Type
Bottle, Glass, Amber
list price/quantitytotal
$0.00
Thomas No.
C830L84
Mfr. No.
0210074091
CAS #
37326-33-3
Description
Hyaluronidase from Bovine Testes, 1g
Packaging Size
1 g
Packaging Type
Bottle, Glass, Amber
list price/quantitytotal
$0.00
$0.00 (0 Items)
Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

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