MP Biomedicals, 5 mg
MP Biomedicals
MP Biomedicals is a worldwide corporation manufacturing and distributing systems, kits and reagents for the life science research, medical device, biopharma manufacturing and diagnostics markets. Our extensive portfolio and custom services deliver the dependability that research and industrial communities rely on to worry less and discover more. From small scale research to large scale manufacturing, MP Biomedicals has been advancing life science projects for over 50 years.
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Angiotensin II Human from Synthetic
MP BiomedicalsAngiotensin II is a peptide hormone which plays an important role in the regulation of blood pressure. It stimulates the release of aldosterone from the adrenal gland. It has strong vasoconstrictive effects. Angiotensin II plays an important role in the regulation of blood pressure. It…
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MBIMPH
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and…
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PS-341 [Bortezomib]
MP BiomedicalsHighly potent, selective and reversible cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Anticancer compound. Inhibits proliferation and migration of several tumor…
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Daunomycin Hydrochloride from Streptomyces peucetius
MP BiomedicalsAn antineoplastic of Rhodomycin group; Antibiotic; Inhibitor of enzymes and metabolic pathways. A potent anticancer agent that has been shown to be a strong inhibitor of DNA and RNA synthesis. Daunorubicin hydrochloride is used in photostability , antileukemic, and drug metabolism studies. …
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Pokeweed Mitogen, Crude, LY
MP BiomedicalsPokeweed mitogen is extracted from pokeweed roots. This protein has hemagglutinating, leukoagglutinating, and mitogenic properties. PWM is not blood group specific, but has affinity for N-acetyl-β-D-glucosamine oligomers. Reconstitution: Reconstitute with 0.01M sodium phosphate-0.15M sodium…
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Actinomycin D from Streptomyces parvalus
MP BiomedicalsActinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity. Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of…
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DABPH
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =12nM). Displays high selectivity over HDAC1 (IC50=6.8µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation.…
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Leupeptin Hemisulfate
MP BiomedicalsLeupeptin is a modified tripeptide reversible protease inhibitor of trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, kallikrein, papain, thrombin, cathepsin B, cathepsins H and L, trypsin, calpain, trypsin8 and plasmin. Effective concentration is typically 10-100…
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Luteolin
MP BiomedicalsAnticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase (15-LOX) inhibitor. IL-6 production inhibitor. Fatty acid synthase (FAS) inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-gamma inhibitor.…
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Leupeptin Hydrochloride
MP BiomedicalsA modified tripeptide reversible protease inhibitor of trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, kallikrein, papain, thrombin, cathepsin B, cathepsins H and L, trypsin, calpain, trypsin and plasmin. Little to no inhibition is seen against pepsin, cathepsins…
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Avidin from Egg White, ~10-15 u/mg Protein
MP BiomedicalsAvidin is a basic glycoprotein consisting of four essentially identical subunits. The combined molecular weight of the subunits is about 66,000. Each subunit is a single polypeptide chain containing 128 amino acid residues with alanine at the N-terminal, glutamic acid at the C-terminal, and a…
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Antipain . dihydrochloride
MP BiomedicalsPotent reversible inhibitor of serine/cysteine proteases and some trypsin-like proteases. Inhibits papain, trypsin and trypsin-like serine proteases as well as cathepsin A, B and D. Similar activity spectrum comparable to leupeptin (AG-CP3-7000). Acts by forming a hemiacetal adduct between its…
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Muscimol
MP BiomedicalsMuscimol is a structural analog of γ-amino butyric acid. It functions as a GABA-agonist: a positive analog of the natural transmitter, which can activate GABA receptors in the brain. Muscimol is an isoxazole derivative occurring naturally in the mushroom Amanita muscaria. Muscimol has been…
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(+)-Aphidicolin
MP BiomedicalsProduct Description Phytotoxin. Antibiotic. Antiviral and antineoplastic agent. Antileishmanial agent. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at G1/S phase. Prolongs the half life of DNA methyltransferase. DNA…
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Limonin from Citrus Seeds
MP BiomedicalsLimonin is a natural compound found in grapefruit and other citrus seeds. Limonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. It has been shown to inhibit chemically induced carcinogenesis and demonstrates anti feedant properties. Limonin may be used in assays to…
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Leupeptin . hemisulfate
MP BiomedicalsPotent, competitive and reversible cysteine, serine and threonine protease inhibitor. Inhibits calpain, kallikrein, trypsin, plasmin, papain and cathepsin B. Does not inhibit pepsin, elastase, renin, cathepsins A and D, thrombin or alpha-chymotrypsin. Used to protect against hearing loss caused by…
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Acetoacetyl Coenzyme A Trisodium Salt Tetrahydrate
MP BiomedicalsAcetoacetyl coenzyme A (Acetoacetyl-CoA) may be used as a substrate for a number of enzymes including; acetoacetyl-CoA thiolase (EC 2.3.1) which produces acetyl-CoA in reverse condensation reaction and (3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS)) which produces…
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Pepstatin A
MP BiomedicalsPepstatin A is a reversible inhibitor of aspartic proteases, Inhibitor for pepsin, renin, cathepsin D, cathepsin G, and other acid proteases. It does not inhibit thiol proteases, neutral proteases or serine proteases. Pepstatin forms a 1:1 complex with acid proteases (carboxyl proteases). …
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Proteinase K from Tritirachium album
MP BiomedicalsProteinase K is a highly active stable endopeptidase with a broad spectrum of action was isolated by E. Merk's Darmstadt Biochemical Research Department in 1970 from a culture filtrate of the fungus, Tritirachium album Limber. This fungus is able to grow on Keratin (e.g., wool, horn particles)…
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FITC-Val-Ala-Asp(Ome)-FMK
MP BiomedicalsFITC-Val-Ala-Asp(OMe)-FMK is an inhibitor for General Caspases.
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PMA
MP BiomedicalsProduct Description Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by…
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Protein A from Staphylococcus aureus, Fc Binding Grade
MP BiomedicalsProtein A is a recombinant Fc-binding protein from Staphylococcus aureus, Cowan strain-1 gene. The product is a carboxy truncated material containing 301 amino acid residues. The non-binding regions have been removed to minimize potenial steric interference. Protein A may be conjugated with…
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Isodesmosine from Bovine Neck Ligament
MP BiomedicalsIsodesmosine is prepared according to the method of Starcher, et al. from hdrolyzed bovine neck ligament by solvent extraction and chromatography on Dowex 50.
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Purified Human Serum IgA
MP BiomedicalsThe product is tested for purity at a minimum of 20 mg/mL using immunoelectrophoresis. The product is human serum IgA; no trace of IgG, IgM or non-immunoglobulin serum proteins is detected. The total protein is determined using the Biuret procedure, with bovine albumin as the standard. Each vial is…
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Cytochalasin B from Helminthosporium dematioideum
MP BiomedicalsCell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport. One of a group of fungal metabolites that interfere with a wide…
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Avidin from Egg White
MP BiomedicalsAvidin is a basic glycoprotein isolated from raw egg white. It exhibits high binding affinity for biotin and is capable of producing biotin deficiency in rats and chicks. It also occurs in the white portion of eggs and the oviducts of birds and amphibia. It is destroyed by cooking or irradiation. …
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BOC-ASP(OMe)-FMK
MP BiomedicalsThe FMK peptides are potent, cell permeable, irreversible inhibitors. It is useful for in vitro and in vivo applications. BOC-ASP(OMe)-FMK is an inhibitor for general Caspases. The novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds…
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DMAPB
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =114nM). Displays selectivity over other HDACs (IC50=1-8µM). Neuroprotective and anti-neuroinflammatory agent. Reduced neuronal degeneration after traumatic brain injury (TBI). Shown to increase histone H3 acetylation. HDAC6…
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E-64 from Synthetic
MP BiomedicalsE-64 is an inhibitor for thiol protease, papain, actinidin, ananain, bromelain, calpain and cathepsin B. It is an irreversible cysteine protease inhibitor that has no action on cysteine residues in other plants and does not react with low molecular weight thiols such as 2-mercaptoethanol. Specific…
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Forskolin
MP BiomedicalsPotent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis…
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Brefeldin A
MP BiomedicalsBrefeldin A is a fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. Produced by Penicillium brefeldianum. Blocks binding of the cytosolic coat protein b-COP and ARF to Golgi membranes mediated by protein G. Also blocks protein transportation into…
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PMPH
MP BiomedicalsCell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation.…