Cayman Chemical, Chemicals, 500 mg
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Bromocriptine (mesylate)
Cayman ChemicalA potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM); avidly binds the serotonin receptors 5-HT1A and 5-HT1D (Ki = 12.9 and 10.7 nM, respectively), as well as α and β adrenoreceptors.
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N-Octyl-ß-D-thioglucopyranoside
Cayman ChemicalA low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.
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2,7-Dichlorodihydrofluorescein diacetate
Cayman ChemicalA fluorescent indicator of peroxynitrite formation; neither NO, superoxide, nor hydrogen peroxide alone appear to oxidize DCFH.
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Bupivacaine
Cayman ChemicalAn amino-amide anesthetic that binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, preventing the generation of an action potential; inhibits the uptake of dopamine in striatal synaptosomes by 47% at 100 µM.
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Arachidonic Acid
Cayman ChemicalKeystone essential fatty acid that is converted by COX, LO, and epoxygenase enzymes into more than 150 potent metabolites in species ranging from fungi to plants to mammals.
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Clinafloxacin (hydrochloride)
Cayman ChemicalA fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).
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Methotrexate
Cayman ChemicalAn analog of folic acid and aminopterin that is used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions; induces adenosine release, inhibits the metabolism of folic acid, and blocks key enzymes in the synthesis of purines and pyrimidines…
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a-D-Galactose-1-phosphate (potassium salt)
Cayman ChemicalAn intermediate in the interconversion of glucose and galactose.
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Imiquimod
Cayman ChemicalAn imidazoquinoline compound that activates TLR7 (EC50 = 2.1 µM) on immune cells, inducing the production of IFN-α, IL-12, and other mediators; up-regulates the OGF receptor on cancer cells, blocking cell proliferation (IC50 = 2 µM).
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Lucigenin
Cayman ChemicalA dual purpose probe; a chemiluminescent probe that detects superoxide production by enzymatic and cellular sources; a fluorescent chloride-sensitive indicator, with fluorescence being quenched by chloride (excitation: 455 nm; emission: 505 nm).
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n-Dodecyl-ß-D-maltoside
Cayman ChemicalA non-ionic detergent commonly used to solubilize membrane-associated proteins; helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation.
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Glutathione ethyl ester
Cayman ChemicalA cell permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH; used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.
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2-cyano-Pyrimidine
Cayman ChemicalCathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and derivatives are being studied for the treatment of osteoporosis.…
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TBTA
Cayman ChemicalA tertiary amine that complexes with, and stabilizes, Cu(I) to accelerate azide-alkyne cycloadditions, as used in click chemistry.
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2'-Deoxyadenosine-5'-monophosphate
Cayman ChemicalA derivative of AMP that has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.
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Lenalidomide
Cayman ChemicalAn analog of thalidomide that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines; induces proliferation and enhances the functional capacity of T-lymphocytes, amplifying co-stimulatory signaling pathways.
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Pargyline (hydrochloride)
Cayman ChemicalPargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension. At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats. The…
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Ketoconazole
Cayman ChemicalAn orally active broad spectrum antifungal agent that blocks ergosterol biosynthesis by inhibiting the fungal CYP isoform CYP51; potently inhibits the mammalian analog CYP51A1 (IC50 = 63.5 nM), as well as a variety of other CYP isoforms.
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Corticosterone
Cayman ChemicalA steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors; also is the precursor to aldosterone synthesis.
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Omeprazole
Cayman ChemicalA selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 μM).
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DMOG
Cayman ChemicalA cell permeable, competitive inhibitor of HIF-1α prolyl hydroxylase; stabilizes HIF-1α expression at normal oxygen tensions in cultured cells at concentrations between 0.1 and 1 mM.
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Capsaicin (technical grade)
Cayman ChemicalCapsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper. Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in…
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2-(hydroxymethyl)-Pyrimidine
Cayman Chemical2-(hydroxymethyl)-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.
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Daidzein
Cayman ChemicalAn isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes.
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Kynurenic Acid
Cayman ChemicalA metabolite of tryptophan that has pronounced effects on neuronal signaling; broadly antagonizes ionotopic glutamate receptors; has potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 µM), GPR35 (EC50 = 39 µM), aryl hydrocarbon receptor (EC50 = 300…
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Pterostilbene
Cayman ChemicalA naturally-occurring dimethyl ether analog of resveratrol; acts as a powerful antioxidant, suppresses the synthesis of PGE2 from LPS-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 μM), and inhibits cell proliferation (IC50 = ~60 μM); evokes effects that…
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Erlotinib
Cayman ChemicalA tyrosine kinase inhibitor which acts on EGFR, inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM) and tumor growth in human HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg; drug form of Erlotinib, Tarceva™, is used to treat certain forms of cancer.
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Tianeptine (sodium salt)
Cayman ChemicalAn atypical antidepressant with diverse actions, most notably on the glutamatergic system; attenuates glutamate release and modulates the function of AMPAR; acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641 nM for human and mouse receptors, respectively).