The flavones and flavonoids are a widespread group of natural products with a variety of reported beneficial health effects. Flavonoids have been implicated as possible active agents in the dietary benefits of citrus fruits. Hesperetin is a citrus flavonoid that has been reported to lower plasma…

Diclofenac is a non-selective COX inhibitor. It inhibits human COX-1 and -2 with IC₅₀ values of 0.9-2.7 and 1.5-20 µM, respectively. Diclofenac inhibits ovine COX-1 and -2 with IC₅₀ values of 60 and 220 nM, respectively.