Cayman Chemical, Chemicals
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Docosahexaenoic Acid-d5
Cayman ChemicalAn internal standard for the quantification of DHA by GC- or LC-MS.
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4-Nitrophenyl ß-D-Cellotrioside
Cayman ChemicalA chromogenic substrate for endoglucanases and cellobiohydrolases.
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PHA-767491
Cayman ChemicalAn inhibitor of Cdc7 kinase (IC50 = 10 nM) as well as Cdk9, (IC50 = 34 nM); induces apoptotic cell death in multiple cancer cell types at 10 µM.
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L-Ascorbic Acid
Cayman ChemicalA naturally occurring electron donor for eight different enzymes, including those related to collagen hydroxylation, carnitine synthesis (which aids in the generation of ATP), norepinephrine synthesis, tyrosine metabolism, and amidating peptides.
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Oenin
Cayman ChemicalA natural anthocyanin that has neuroprotective effects, reducing amyloid β-induced cytotoxicity in Neuro-2A cells; stimulates autophagy in U2OS cells.
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Isradipine
Cayman ChemicalA selective L-type calcium channel blocker with long-acting antihypertensive activity; relaxes depolarization-induced contractions of rabbit aorta (EC50 = 1.4 nM) and reduces the rate of spontaneously beating guinea pig right atria (EC25 = 0.45 nM); attenuates β-amyloid…
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Cisplatin
Cayman ChemicalA platinum-containing compound that acts as an alkylating agent; used alone or in combination therapy in the treatment of several types of cancer; inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth.
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Ionomycin (calcium salt)
Cayman ChemicalA selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to stimulate the intracellular production of cytokines.
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Nitrendipine
Cayman ChemicalA dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels; also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively.
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Cannabinolic Acid (CRM)
Cayman ChemicalA certified reference material categorized as a phytocannabinoid; intended for research and forensic applications
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5-Octyl-a-ketoglutarate
Cayman ChemicalA stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis by cytoplasmic esterases; used in experiments to increase levels of intracellular α-ketoglutarate and modulate a variety of enzymes, particularly in the context of glycolysis, hypoxia, and cancer.
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Myeloperoxidase Peroxidation Fluorometric Assay Kit
Cayman ChemicalCayman’s MPO Peroxidation Fluorometric Assay provides a convenient fluorescence-based method for detecting MPO peroxidase activity in both crude cell lysates and purified enzyme preparations. The assay utilizes the peroxidase component of MPO. The reaction between hydrogen peroxide and…
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(±)-Jasmonic Acid methyl ester
Cayman ChemicalA mixture of trans (3R/7R and 3S/7S) isomers; induces the synthesis of proteinase inhibitors in plant leaves; in cancer cells, suppresses proliferation and induces apoptosis; inhibits hexokinase that is bound to mitochondria; methyl jasmonate derivatives also have potential as anti-inflammatory agents.
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iNOS Polyclonal Antibody
Cayman ChemicalAntigen: purified enzyme from mouse macrophages (RAW 264.7 cells) Host: rabbit Cross Reactivity: (+) iNOS from most mammalian species and nNOS (~5%); (−) eNOS Application(s): ICC, IP, and WB NOS catalyzes the biosynthesis of nitric oxide from L-arginine. iNOS is a soluble enzyme…
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Losartan Carboxylic Acid
Cayman ChemicalA physiologically active metabolite of losartan; a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.
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Ionomycin
Cayman ChemicalA selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to stimulate the intracellular production of cytokines.
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Oleoyl Serotonin
Cayman ChemicalA hybrid molecule patterned after N-arachidonoyl serotonin; inhibits capsaicin-induced TRPV1 channel activation (IC50 = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
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PD 153035 (hydrochloride)
Cayman ChemicalA highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC50 = 29 pM); rapidly suppresses autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells.
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Acivicin
Cayman ChemicalA glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively); reversibly inhibits γ-glutamyl transpeptidase.
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U-18666A
Cayman ChemicalA cell permeable drug that inhibits cholesterol trafficking from late endosomes/lysosomes to the ER, but not to the plasma membrane.
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Glutathione Assay Kit
Cayman ChemicalCayman’s GSH Assay utilizes a carefully optimized enzymatic recycling method for the quantification of GSH in a 96-well microplate format. It measures both GSH and GSSG to reflect total glutathione in a sample. The kit can also be used to measure only GSSG by following an alternative…
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KC7F2
Cayman ChemicalAn inhibitor of HIF-1α protein translation; suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase; cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM.
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Lenalidomide
Cayman ChemicalAn analog of thalidomide that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines; induces proliferation and enhances the functional capacity of T-lymphocytes, amplifying co-stimulatory signaling pathways.
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Ketoprofen
Cayman ChemicalA non-selective NSAID exhibiting IC50 values of 0.5 and 2.33 µM for human recombinant COX-1 and COX-2, respectively.
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Alanine Transaminase Colorimetric Activity Assay Kit
Cayman ChemicalALT is a homodimeric cytoplasmic pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. Cayman’s Alanine Transaminase Assay provides a convenient method of detecting ALT activity in serum, plasma, tissue samples, and…
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Glycogen Assay Kit
Cayman ChemicalGlycogen is the principal storage form of glucose in animal and human cells. It is made primarily by the liver and muscles, but it can also be made by glycogenesis within the brain and stomach. Cayman’s Glycogen Assay provides a simple, reproducible, and sensitive tool for assaying glycogen…
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13(S)-HODE-biotin
Cayman Chemical13(S)-HODE is the LO metabolite of linoleic acid. 13(S)-HODE modulates the PAF, LTB4, and fMLP-induced calcium influx in human PMNL. The mechanism by which 13(S)-HODE elicits its inhibitory effect is still unclear. The use of biotinylated 15(S)-HETE as a probe for detecting binding proteins and/or…
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Dihomo-y-Linolenic Acid ethyl ester
Cayman ChemicalDGLA is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Ethyl DGLA is an esterified version of the free acid which is less water soluble, but more ammenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as…
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Tetrodotoxin
Cayman ChemicalA potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.