NEW! Life Science, 1 mg, Cayman Chemical
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BQU57
Cayman ChemicalFormal Name: 6-amino-1,4-dihydro-1,3-dimethyl-4-[4-(trifluoromethyl)phenyl]-pyrano[2,3-c]pyrazole-5-carbonitrile CAS Number: 1637739-82-2 Molecular Formula: C16H13F3N4O Formula Weight: 334.3
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Letermovir
Cayman ChemicalA small molecule inhibitor of human cytomegalovirus viral replication (EC50 = ~5 nM with a selectivity index >15,000) that targets viral DNA cleavage and packaging.
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Tetrodotoxin
Cayman ChemicalA potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.
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SB-743921 (hydrochloride)
Cayman ChemicalCAS Number: 940929-33-9 Molecular Formula: C31H33ClN2O3 • HCl Formula Weight: 553.5
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GS-5885
Cayman ChemicalAn inhibitor of non-structural protein 5A of hepatitis C virus; effectively reduces or eliminates certain genotypes of hepatitis C virus in vivo, particularly when used in combination with other agents.
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Linolein Hydroperoxides
Cayman ChemicalLinolein hydroperoxides are a mixture of 132 possible isomers of mono-, di-, and tri-hydroperoxides produced from the autoxidation of trilinolein. Autoxidation of linoleic acid containing triglycerides (for example, trilinolein) in vivo could result in the formation of these hydroperoxides. Unlike…
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NF449 (sodium salt)
Cayman ChemicalAn analog of suramin that selectively inhibits P2X1 receptors (pIC50 = 6.3); selectively antagonizes the Gsα-subunit G protein, which suppresses the association rate of GTPγS binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks G protein coupling to…
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(±)-ß-Hydroxybutyrate-d4 (sodium salt)
Cayman ChemicalAn internal standard for the quantification of (±)-β-hydroxybutyrate (sodium salt) by GC- or LC-MS.
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Arachidonoyl p-Nitroaniline
Cayman ChemicalApNA is one of several nitroaniline fatty acid amides which can be used to measure FAAH activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate AEA (Item No. 90050). It also will hydrolyze…
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(S)-p38 MAP Kinase Inhibitor III
Cayman ChemicalA methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 µM in vitro); potently blocks the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 µM, respectively).
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PFI-3
Cayman ChemicalBinds avidly and selectively to the structurally-similar bromodomains of SMARCA4 and PB1(domain 5) with Kd values of 89 and 48 nM, respectively; also interacts with the bromodomain of SMARCA2; does not interact with other bromodomains or with a panel of kinases.
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CYM 5442
Cayman ChemicalA selective SIP1 agonist (EC50 = 1.35 nM); activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC50 = 46 nM); induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively, at 50 nM.
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SB-525334
Cayman ChemicalA potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC50 = 14.36 nM); blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression; effective in vivo, preventing the development of fibrosis in animals.
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Chymostatin
Cayman ChemicalA potent inhibitor of chymotrypsin and chymase (Ki = 9.36 and 13.1 nM, respectively), that less effectively blocks the activity of cathepsins, papain, and leukocyte elastase.
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Tetrodotoxin Citrate
Cayman ChemicalA potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.
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ß-Zearalenol
Cayman ChemicalA hepatic metabolite of zearalenone that is a less potent agonist of estrogen receptors than the parent compound.
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Zearalanone
Cayman ChemicalA major phase I metabolite of the mycotoxin α-zearalanol (zeranol), a non-steroidal estrogen produced by fungi; an estrogen receptor agonist (EC50 = 0.11 µM).
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ONO-8711
Cayman ChemicalA potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1, respectively); effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer; suppresses pain and acid-induced HCO3- secretion in the stomach.
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K252c
Cayman ChemicalK252c is a cell-permeable PKC inhibitor (IC50s = 2.45 and 25.7 µM for PKC and PKA, respectively). It induces apoptosis in human chronic myelogenous leukemia cancer cells. In human foreskin fibroblast cells, it reduces focus formation induced by human cytomegalovirus (HCMV) strains…
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Green CMFDA
Cayman ChemicalA cell-permeable fluorescent probe that freely enters living cells, where it is transformed into a cell-impermeable, soluble, fluorescent compound; does not affect cell viability or proliferation and stably fluoresces for at least 72 hours, allowing for its use in cell tracking.
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Cannabigerovarin
Cayman ChemicalAn analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications
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Cannabigerolic Acid
Cayman ChemicalAn analytical reference material categorized as a phytocannabinoid; a precursor in the biosynthesis of tetrahydrocannabinolic acid, cannabidiolic acid, and cannabichromenic acid; intended for research and forensic applications
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Cannabigerorcin
Cayman ChemicalAn analytical reference standard categorized as a phytocannabinoid; intended for research and forensic applications,
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CBDB
Cayman ChemicalAn analytical reference standard categorized as a phytocannabinoid; considered an impurity in commercial preparations of cannabidiol; intended for research and forensic applications
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Jacaric Acid
Cayman ChemicalA conjugated PUFA that induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM); increases the production of ROS, leading to oxidative stress that contributes to cytotoxicity.
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Oligomycin B
Cayman ChemicalA nonselective inhibitor of the mitochondrial F1FO ATP synthase that can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.
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HE-3235
Cayman ChemicalA synthetic adrenal hormone, an androstanediol analog, that acts as an androgen receptor antagonist; inhibits androstenediol-dependent LNCaP cell tumor growth both in vitro (IC50 = 6 nM) and in vivo.
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Lutein
Cayman ChemicalA natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina; a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.
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AZD 2932
Cayman ChemicalCAS Number: 883986-34-3 Molecular Formula: C24H25N5O4 Formula Weight: 447.5
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Lactacystin
Cayman ChemicalA microbial metabolite isolated from Streptomyces that is widely used as a selective inhibitor of the 20S proteasome.
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CB-5083
Cayman ChemicalCB-5083 is an orally bioavailable inhibitor of p97 (IC50 = 11 nM), a transitional endoplasmic reticulum ATPase also known as valosin-containing protein (VCP). It disrupts cellular protein homeostasis and demonstrates anti-tumor activity in hematological and solid tumor models. CB-5083…