NEW! Life Science, 1 mg
-
Bakuchiol
Cayman ChemicalA natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).
-
FSLLRY-amide
Cayman ChemicalA peptide antagonist of PAR2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2; does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein; used to study PAR2 action in cells and in animals.
-
-
MLCK Inhibitor Peptide 18
Cayman ChemicalA selective, cell permeable inhibitor of MLCK (IC50 = 50 nM).
-
4-Methylumbelliferyl 6-thio-Palmitate-ß-D-Glucopyranoside
Cayman ChemicalA fluorogenic substrate of palmitoyl-protein thioesterase.
-
Taurolithocholic Acid 3-sulfate (sodium salt)
Cayman ChemicalA sulfated bile acid that is used to induce pancreatic acinar cell injury in models of pancreatitis and to study bile acid transport.
-
-
Exendin-4 (acetate)
Cayman ChemicalA potent peptide agonist of the GLP-1 receptor (Ki = 136 pM); stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes; protects hippocampal neurons against glutamate-induced apoptosis.
-
5-trans Prostaglandin E2
Cayman Chemical5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates. 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by…
-
AH 23848 (calcium salt)
Cayman ChemicalA dual antagonist of TP and EP4 receptors; inhibits TxA2-induced platelet aggregation (IC50 = 0.26 μM) and bronchial smooth muscle contraction; impairs PGE2-mediated relaxation of piglet saphenous vein, suppresses serum-induced proliferation of fibroblasts, and reduces metastasis in a…
-
ML-7 (hydrochloride)
Cayman ChemicalInhibits smooth MLCK (Ki = 0.3 µM) 10-fold more potently than its parent compound ML-9.
-
MeOSuc-Ala-Ala-Pro-Val-AMC
Cayman ChemicalA fluorogenic substrate for human leukocyte and porcine pancreatic elastase; excitation: 355-380 nm; emission 440-460 nm.
-
Wnt-C59
Cayman ChemicalA potent inhibitor of PORCN (IC50 = 74 pM), completely blocking Wnt secretion into culture media; prevents activation of all evaluated Wnt family members; effective in vivo as well as in vitro; blocks the progression of breast cancer while downregulating Wnt/β-catenin pathway target…
-
(R)-MG132
Cayman ChemicalA potent, reversible, and cell permeable proteasome inhibitor; a more effective inhibitor of chymotrypsin-like, trypsin-like, and peptidylglutamyl peptide hydrolyzing proteasome activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 µM (ChTL); 34.4 versus 104.43 µM (TL);…
-
22(R)-hydroxy Cholesterol
Cayman ChemicalAn endogenous agonist for LXRα (EC50 = 325 nM) that can induce the expression of the ABCA1 reverse cholesterol transporter to inhibit the overall absorption of cholesterol; used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists.
-
17-phenyl trinor Prostaglandin A2
Cayman Chemical17-phenyl trinor PGA2 is a synthetic prostaglandin analog designed for increased half-life and greater potency. There are no published reports of the biological activity of 17-phenyl trinor PGA2 in the literature at this time.
-
HDMAPP (ammonium salt)
Cayman ChemicalA microbial metabolite that binds the TCR on Vγ9Vδ2 peripheral blood lymphocytes with high affinity (EC50 = 0.39 nM); induces the expansion of human memory Vγ9Vδ2 T cells.
-
SB 277011A (hydrochloride)
Cayman ChemicalA selective antagonist of the dopamine D3 receptor (pKi = 8.0); has high oral bioavailability and enters the central nervous system of the rat.
-
ONO-8711
Cayman ChemicalA potent and selective competitive antagonist of the EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1, respectively); effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer; suppresses pain and acid-induced HCO3- secretion in the stomach.
-
8-iso Prostaglandin F2ß
Cayman Chemical8-iso PGF2β is an isomer of PGF2α with a non-enzymatic, non-cyclooxygenase origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and…
-
Gö 6983
Cayman ChemicalInhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively); provides cardioprotective effects in myocardial ischemia/reperfusion.
-
SU 9516
Cayman ChemicalA potent inhibitor of several CDKs with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1); has anti-proliferative and pro-apoptotic activity in tumor cells.
-
SMI-481
Cayman ChemicalAn inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 µM, respectively).
-
12-OAHSA
Cayman ChemicalA FAHFA in which oleic acid occurs at the 12-position on hydroxy stearic acid.
-
Bioymifi
Cayman ChemicalA DR5 agonist (Kd= 1.2 µM; IC50 = 2 µM) that induces DR5 clustering, which leads to the initiation of FADD/caspase-8-dependent apoptosis in various cancer cells.
-
PD 158780
Cayman ChemicalA reversible inhibitor of the auto and transphosphorylation kinase activity of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 µM), ErbB-2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM); induces G1 cell cycle arrest in MCF10A breast cancer cells.
-
CHIR99021
Cayman ChemicalAn aminopyrimidine derivative that inhibits GSK3α and GSK3β (IC50s = 10 and 6.7 nM, respectively); activates glycogen synthesis in CHO-IR cells (EC50 = 0.8 μM) and in isolated type 1 diabetic rat skeletal muscle; has been shown to promote self-renewal of embryonic stem cells.
-
IDO-IN-1
Cayman ChemicalIDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor that demonstrates IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively. It is inactive against tryptophan 2,3-dioxygenase (TOD; IC50 > 10 µM).
-
Adipokinetic Hormone, locust
LKT LabsAdipokinetic hormone is a neuropeptide hormone found in insects that is involved in the regulation of circadian rhythms. Adipokinetic hormone also increases activity of peptidase, lipase, amylase, and polygalacturonase in the salivary glands. In brain samples treated with H2O2, this peptide…
-
-
4-Methylumbelliferyl-ß-D-N,N',N''-Triacetylchitotrioside
Cayman ChemicalA fluorogenic substrate for chitinases and chitotriosidases.
-
Ochratoxin A
Cayman ChemicalA mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,…