Viral Gene Delivery

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Viral Gene Delivery

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  • Inducible tet-on FOXG1 lentivirus

    Cellomics Technology

    Fork-head box protein G1 (FOXG1) is an evolutionarily conserved, winged-helix transcriptional repressor that that regulates neurogenesis. The FOXG1 gene has been recently implicated in the congenital form of Rett syndrome (RTT), a severe neurodevelopmental disorder.

  • NEUROD1 is a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and…

  • Inducible tet-on Chx10 lentivirus

    Cellomics Technology

    The homeodomain transcription factor Chx10 is one of the earliest markers of the developing retina. It is required for retinal progenitor cell proliferation as well as formation of bipolar cells, a type of retinal interneuron.

  • Calcium is a universal second messenger regulating essential cellular signaling events in a broad range of tissues and organisms. GCaMP3 is a fusion calcium indicator of green fluorescent protein (GFP), calmodulin and the M13 domain of a myosin light chain kinase designed to show the calcium ion…

  • Calcium is a universal second messenger regulating essential cellular signaling events in a broad range of tissues and organisms. GCaMP3 is a fusion calcium indicator of green fluorescent protein (GFP), calmodulin and the M13 domain of a myosin light chain kinase designed to show the calcium ion…

  • TGFß/SMAD reporter lentivirus

    Cellomics Technology

    The TGFβ/SMAD reporter lentivirus is designed for monitoring the activity of the TGFβ/SMAD signaling pathway. The transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell…

  • UBC-GFP lentivirus

    Cellomics Technology

    Green fluorescent protein (GFP), a 27 kDa protein derived from the jellyfish Aequorea victoria, emits green light (emission peak at a wavelength of 509 nm) when excited byblue light (excitation peak at a wavelength of 395 nm). Green Fluorescent Protein (GFP) has become an invaluable tool in cell…

  • Inducible tet-on Ars2 lentivirus

    Cellomics Technology

    Ars2 (arsenite-resistance protein 2; also known as Srrt) is a highly conserved zinc finger protein. Ars2 is necessary and sufficient to promote NSC (neural stem cells) self-renewal. This premade lentivirus expresses Ars2 under the control of Tet promoter.

  • EF1A-NANOG_m lentivirus

    Cellomics Technology

    NANOG is a transcription factor important for maintaining the self-renewal capacity of undifferentiated stem cells. Ectopic expression of NANOG has been used to generate iPS cells in culture. Human elongation factor-1 alpha (EF-1 alpha) is a constitutive promoter of human origin that can be used…

  • CMV-rtTA lentivirus (Neo)

    Cellomics Technology

    This strain carries the tetracycline reverse transcriptional activator (rtTA) under the control of the CMV promoter. The rtTA binds to tetracycline operator elements (TetO) in the presence of doxycycline, causing transcriptional activation of genes downstream of TetO.

  • The ViraTrap™ adenovirus mini purification kit is designed for fast and efficient purification of recombinant Adenovirus from adenovirus transfected cell culture supernatant. Up to 1 x10 12 viral particles can be purified from cell culture media of 1 to 2 T75 flasks. Traditionally the…

  • Inducible tet-on KLF4 lentivirus

    Cellomics Technology

    Krueppel-like factor 4 (KLF4) is a zinc finger transcriptional regulator that has been identified as a good indicator of stem cell-like capacity and is subsequently used in iPS cell generation. KFL4 plays an important role in maintaining stem cells, and in preventing their differentiation. This…

  • CMV-TNFSF12 lentivirus

    Cellomics Technology

    TNFSF12 is a member of the tumor necrosis factor (TNF) ligand family. TNFSF12 is a ligand for the FN14/TWEAKER receptor involved in apoptosis and angiogenesis. This lentivirus expresses human TNFSF12 under the control of the CMV promoter.

  • Luciferase is an enzyme that is catalyzes the oxidation of luciferin to generate bioluminescence. Firefly luciferase refers to the enzyme that was isolated from Photinus pyralis.

  • Luciferase is an enzyme that is catalyzes the oxidation of luciferin to generate bioluminescence. Firefly luciferase refers to the enzyme that was isolated from Photinus pyralis. This lentivirus coexpresses Firefly luciferase and puromycin driven by the CMV promoter, allowing generation of Firefly…

  • This set contains four CMV-driven vectors: SOX2 (PLV-10008), OCT3/4 (PLV-10007), KLF4 (PLV-10006) and C-MYC (PLV-10005).

  • Angpt1 gene encodes a secreted glycoprotein called Angiopoietin 1 that activates the receptor by inducing its tyrosine phosphorylation. It appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. It may also mediate blood…

  • CMV-MAD2 lentivirus

    Cellomics Technology

    MAD2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2 was showed to be associated with tumor differentation. This lentivirus express human MAD2 under the control of the CMV promoter.

  • Angiogenin (Ang) shRNA lentivirus

    Cellomics Technology

    Angiogenin (Ang) gene encodes a mediator of new blood vessel formation that hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. It interacts with DNA causing a promoter-like increase in the expression of rRNA. Angiogenic activity is…

  • Inducible tet-on OCT3/4 lentivirus

    Cellomics Technology

    OCT3/4 (POU5F1) is a transcription factor that is expressed in stem cells and germ cells. Its expression is required to sustain cell self-renewal of undifferentiated stem cells. Oct-3/4 is the most recognized marker for totipotent ES cells. Ectopic expression of OCT3/4 has been used to produce iPS…

  • CAG-GFP lentivirus

    Cellomics Technology

    Green fluorescent protein (GFP), a 27 kDa protein derived from the jellyfish Aequorea victoria, emits green light (emission peak at a wavelength of 509 nm) when excited byblue light (excitation peak at a wavelength of 395 nm). Green Fluorescent Protein (GFP) has become an invaluable tool in cell…

  • Cre Recombinase is a tyrosine recombinase enzyme derived from the P1 Bacteriophage. The enzyme uses a topoisomerase I like mechanism to carry out site specific recombination events. The enzyme (38kDa) is a member of the Integrase family of site specific recombinase and it is known to catalyse the…

  • EF1A-C-MYC lentivirus

    Cellomics Technology

    MYC (C-MYC) is a regulator gene that codes for a transcription factor is believed to regulate expression of 15% of all genes. C-MYC is one of the genes that has been used to generate iPS cells in culture. Human elongation factor-1 alpha (EF-1 alpha) is a constitutive promoter of human origin…

  • This NF-kB reporter lentivirus expresses Firefly luciferase under the control of a minimal (m)CMV promoter and tandem repeats of the NF-kB transcriptional response element (TRE). It can be used to monitor the transcriptional activity of NF-kB.

  • Inducible tet-on PRDM1 lentivirus

    Cellomics Technology

    PR domain containing 1 with zinc finger domain (PRDM1)/B lymphocyte–induced maturation protein 1 (BLIMP1) is a transcriptional repressor. PRDM1 plays fundamentally important roles in many cell lineages and in the early development of several cell types, including B and T lymphocytes, germ…

  • CMV-SIX3 lentivirus

    Cellomics Technology

    SIX3 is a member of the sine oculis homeobox transcription factor family and plays a role in eye development. Mutations in SIX3 have been associated with holoprosencephaly type 2. This lentivirus expresses human SIX3 under the control of the CMV promoter.

  • Inducible tet-on ASCL1 lentivirus

    Cellomics Technology

    ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) is a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding.…

  • EF1A-RFP lentivirus

    Cellomics Technology

    TurboRFP is a red (orange) fluorescent protein (ex. 553 and em. 574 nm) derived from sea anemoneEntacmaea quadricolor [Merzlyak et al., 2007]. Possessing high photostability and pH stability, TurboRFP is more than twice brighter than DsRed2. Fast TurboRFP maturation makes it clearly detectable in…

  • Inducible tet-on Hnf4a lentivirus

    Cellomics Technology

    Hnf4a is a nuclear transcription factor which binds DNA as a homodimer. Hnf4a controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver,…

  • It has been observed that microRNA miR-183 plays an important role in tumorigenesis and cancer metastasis. This lentivirus expresses miR-183 under the control of the Tet promoter.

  • CMV-RAX lentivirus

    Cellomics Technology

    RAX (Retina And Anterior Neural Fold Homeobox) is a homeobox-containing transcription factor that functions in eye development. RAX is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in…

  • CMV-Renilla luciferase lentivirus

    Cellomics Technology

    Luciferase is an enzyme that is catalyzes the oxidation of luciferin to generate bioluminescence. Renilla luciferase refers to the enzyme that was isolated from the sea pansy, Renilla reniformis.

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