Biologically Active Small Molecules, 1.0 mg, LKT Labs
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3-tert-Butyl-4-Hydroxyanisole
LKT Labs3-Tert-butyl-4-hydroxyanisole (3-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative and anticancer activities. In leukemia cells, 3-BHA decreases the mitochondrial membrane potential, inhibits mitochondrial oxidative…
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Clodronate Disodium Tetrahydrate
LKT LabsClodronate is a first-generation non-nitrogen-containing bisphosphonate that is used clinically for its anti-resorptive activity. Clodronate generates formation of a non-hydrolysable ß-? ATP analog that inhibits mitochondrial ADP/ATP translocase and prevents mitochondrial oxygen consumption…
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N-Acetyl-S-(N’-phenylthiocarbamoyl)-L-cysteine (PITC) is a cysteine conjugate of N-acetyl-phenylisothiocyanate. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer…
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Citrinin
LKT LabsCitrinin is a mycotoxin initially produced by Penicillum, Aspergillus, and Monascus. Citrinin exhibits cytotoxic, cardiotoxic, nephrotoxic, and pro-oxidative activities. In leydig cells, citrinin inhibits testosterone production and induces caspase-mediated apoptosis. In embryos, citrinin alters…
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Chrysophanol
LKT LabsChrysophanol is an anthraquinone originally found in species of Rheum. Chrysophanol exhibits anti-inflammatory, antiviral, antibiotic, and anticancer activities. In animal models of cerebral ischemia/reperfusion, chrysophanol inhibits activation of the NALP3 inflammasome, ameliorating…
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3-tert-Butyl-5-Methoxycatechol
LKT Labs3-Tert-butyl-5-methoxy-catechol exhibits anticancer activity, inhibiting proliferation of leukemia cells. This compound may also induce cellular differentiation in vitro.
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Acivicin
LKT LabsAcivicin is a fermentation product of Streptomyces; it is a glutamine analog. Acivicin inhibits ?-glutamyl transferase, CTP synthetase, GMP synthetase, and FGAM synthetase, preventing purine synthesis. Acivicin exhibits anticancer and antifungal activity, although its potential chemotherapeutic…
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Actinomycin
LKT LabsActinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…
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Adefovir
LKT LabsAdefovir is an antiviral prodrug that displays immunomodulatory activity. Adefovir is an acyclonucleotide analog that inhibits viral DNA polymerase, acting as a DNA chain terminator. Adefovir is primarily used to treat hepatitis B infection, but also displays activity against retroviruses. Adefovir…
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Bulleyaconitine A
LKT LabsBulleyaconitine A (BLA) is found in Aconitum bulleyanum and exhibits analgesic and anesthetic activity. BLA has been used as a treatment for a variety of pain-related and inflammatory disorders. BLA inhibits voltage-gated Na+ channels in a use-dependent manner, reducing peak Na+ currents during…
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Bursin
LKT LabsBursin is a tripeptide that induces B-cell differentiation. Bursin’s immunostimulatory activity allows it to be used as an adjuvant for immunizations. Grade: ≥95%
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N-Acetyl-S-(N’-phenylhexylthiocarbamoyl)-L-cysteine (PHITC) is a cysteine conjugate of N-acetyl-phenylhexylisothiocyanate. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative,…
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N-Acetyl-S-(N’-methylthiocarbamoyl)-L-cysteine (AMITC) is a cysteine conjugate of N-acetyl-methylisothiocyanate. AMITC is a pesticide typically used to fumigate wheat and other grain crops, killing pests such as grain beetles and weevils. AMITC also exhibits anti-parasitic activity,…
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Chromomycin A3
LKT LabsChromomycin A3 is an anthraquinone that exhibits antibacterial and anticancer chemotherapeutic activity. Chromomycin A3 binds Mg2+ and Zn2+ ions, and these complexes bind GC sequences in nucleosomal DNA; this inhibits DNA gyrase, RNA polymerase, and DNA transcription. Chromomycin inhibits growth of…
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AZD-4547
LKT LabsAZD-4547 is an inhibitor of FGFR that is somewhat selective for FGFR2 over FGFR1 and FGFR3; it exhibits anticancer chemotherapeutic activities. This compound is currently in clinical trials as a potential treatment for breast cancer. In breast cancer cells, AZD-4547 induces apoptosis and inhibits…
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Adefovir Dipivoxil
LKT LabsAdefovir dipivoxil is the diester form of adefovir, an antiviral prodrug that displays immunomodulatory activity. Adefovir is an acyclonucleotide analog that inhibits viral DNA polymerase, acting as a DNA chain terminator. Adefovir is primarily used to treat hepatitis B infection, but also displays…
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N-Acetyl-S-(N’-methylthiocarbamoyl)-L-cysteine (AMITC) is a cysteine conjugate of N-acetyl-methylisothiocyanate. AMITC is a pesticide typically used to fumigate wheat and other grain crops, killing pests such as grain beetles and weevils. AMITC also exhibits anti-parasitic activity,…
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N-Acetyl-S-(N’-benzylthiocarbamoyl)-L-cysteine (ABITC) is a cysteine conjugate of N-acetyl-benzylisothiocyanate; acetylbenzyl isothiocyanate-L-cysteine is a derivative of benzyl isothiocyanate-L-cysteine (BITC). Isothiocyanates are typically found in plants of the Brassicaceae family,…
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Aconitine
LKT LabsAconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis.…
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Brivudine
LKT LabsBrivudine is a L-nucleoside analog of thymidine that exhibits antiviral, anticancer chemotherapeutic, and insecticidal activities. Brivudine inhibits herpes simplex virus (HSV-1) thymidine kinase, preventing DNA chain elongation and inhibiting viral growth. Brivudine also binds heat shock protein…
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Cabozantinib
LKT LabsCabozantanib is an anticancer chemotherapeutic compound that has been approved to treat medullary thyroid cancer and is in clinical trials as a treatment for other types of solid tumors. Cabozantanib exerts its anticancer activity through inhibition of Met, RET, and VEGFR2, increasing apoptosis and…
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Butein
LKT LabsButein is a flavonoid originally found in the bark of Rhus verniciflua and the flowers of Butea monosperma. Butein exhibits anticancer chemotherapeutic, anti-angiogenic, neuroprotective, anti-inflammatory, antioxidative, and anti-fibrotic activities. In lung cancer cells, butein decreases…
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Brompheniramine Maleate
LKT LabsBrompheniramine is a halogenated antihistamine derivative of pheniramine that exhibits anticholinergic and neuromodulatory activities. Brompheniramine inhibits the H1 histamine receptor and also displays non-selective inhibition of muscarinic acetylcholine receptors (mAChRs). Brompheniramine…
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BX-795
LKT LabsBX-795 inhibits PDK1, exhibiting anticancer chemotherapeutic activity. BX-795 inhibits Akt signaling, inducing apoptosis and suppressing tumor growth. Grade: ≥98%
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4-tert-Butyl-5-Methoxycatechol
LKT Labs4-Tert-butyl-5-methoxy-catechol exhibits anticancer activity, inhibiting proliferation of leukemia cells.