Acivicin is a fermentation product of Streptomyces; it is a glutamine analog. Acivicin inhibits ?-glutamyl transferase, CTP synthetase, GMP synthetase, and FGAM synthetase, preventing purine synthesis. Acivicin exhibits anticancer and antifungal activity, although its potential chemotherapeutic…

Citalopram is a selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter (SERT); citalopram is clinically used for its antidepressant and anxiolytic activities, although it may prolong the QT interval. The S-isomer of citalopram is active and is sold on its own as…

Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…

N-Acetyl-S-(N’-phenylthiocarbamoyl)-L-cysteine (PITC) is a cysteine conjugate of N-acetyl-phenylisothiocyanate. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative, anticancer…

Chrysophanol is an anthraquinone originally found in species of Rheum. Chrysophanol exhibits anti-inflammatory, antiviral, antibiotic, and anticancer activities. In animal models of cerebral ischemia/reperfusion, chrysophanol inhibits activation of the NALP3 inflammasome, ameliorating…

Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…

Bursin is a tripeptide that induces B-cell differentiation. Bursin’s immunostimulatory activity allows it to be used as an adjuvant for immunizations. Grade: ≥95%

N-Acetyl-S-(N’-phenylhexylthiocarbamoyl)-L-cysteine (PHITC) is a cysteine conjugate of N-acetyl-phenylhexylisothiocyanate. Isothiocyanates are typically found in plants of the Brassicaceae family, including broccoli, cabbage, and radish. Isothiocyanates are best known for their antioxidative,…

N-Acetyl-S-(N’-methylthiocarbamoyl)-L-cysteine (AMITC) is a cysteine conjugate of N-acetyl-methylisothiocyanate. AMITC is a pesticide typically used to fumigate wheat and other grain crops, killing pests such as grain beetles and weevils. AMITC also exhibits anti-parasitic activity,…

This peptide is a substrate for caspase 1 and is used to measure caspase activity in cellular assays.

Chymostatin is an inhibitor of proteases such as chymase that is used in research models.

Ac-IETD-pNA is a peptide substrate used to measure activity of caspase 8. Grade: ≥95%

Ciprofibrate is a PPARa agonist that exhibits anti-hyperlipidemic activity. Clinically, ciprofibrate decreases levels of triglycerides and total cholesterol and increases levels of HDL. In hepatoma cells, ciprofibrate increases NF-?B DNA binding activity. Additionally, ciprofibrate induces…

Acitretin is an orally bioavailable retinoid that displays anti-inflammatory activity and is used clinically to treat psoriasis. Acitretin is a metabolite of etretinate that displays more optimized pharmacokinetic parameters. This compound activates all retinoic acid receptor subtypes…

Ac-VEID-pNA is a peptide substrate used to measure activity of caspase 6.

Substrate used to measure caspase activity. Grade: ≥95%

Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…

Ciglitazone is a thiazolidinedione that exhibits antihypertensive, anticancer, and anti-diabetic activities. Ciglitazone acts as an agonist at PPAR? receptors, decreasing insulin levels, VEGF production, and blood pressure. In cellular models of stomach cancer, ciglitazone induces G1 phase cell…

Mast cell stabilizer used to treat seasonal allergic rhinitis.

This compound is an N-acetyl cysteine conjugate of phenethylisothiocyanate (PEITC-NAC), exhibiting anticancer chemotherapeutic and chemopreventive activities. In lung cancer and prostate cancer models, PEITC-NAC increases activation of JNK, p53, and MAPKs, inducing apoptosis, decreasing tumor…

N-Acetyl-S-(N’-benzylthiocarbamoyl)-L-cysteine (ABITC) is a cysteine conjugate of N-acetyl-benzylisothiocyanate; acetylbenzyl isothiocyanate-L-cysteine is a derivative of benzyl isothiocyanate-L-cysteine (BITC). Isothiocyanates are typically found in plants of the Brassicaceae family,…

N-Acetyl-S-(N’-methylthiocarbamoyl)-L-cysteine (AMITC) is a cysteine conjugate of N-acetyl-methylisothiocyanate. AMITC is a pesticide typically used to fumigate wheat and other grain crops, killing pests such as grain beetles and weevils. AMITC also exhibits anti-parasitic activity,…

This compound is a conjugate of N-acetyl-cysteine and sulforaphane. Like other isothiocyanates (ITCs), this compound likely displays antioxidative activity. Grade: ≥98%

Acepromazine is a phenothiazine derivative antipsychotic agent related to chlorpromazine. Acepromazine maleate is primarily used in veterinary field as a sedative and antiemetic, although it has previously been used as an antipsychotic in humans. Acepromazine acts as an antagonist at D1/2 and…

CKS-17 is a synthetic peptide with a sequence homologous to endogenous retroviral transmembrane envelope proteins; it exhibits immunosuppressive activity in vitro and in vivo. In one study, CKS-17 inhibits production of IL-12, IL-2, TNF-a, and IFN-y, increases levels of cAMP and IL-10, and…

Ac-IEAR-pNA is a peptide substrate used to measure activity of caspases. Grade: ≥95%

Aconitine is a toxin found in Aconitum that exhibits antipyretic, antihypertensive, analgesic, and antinociceptive activities. Aconitine binds neurotoxin binding site 2 of Na+ channels, forcing the channel to stay open longer, allowing continual depolarization, Na+ influx, and eventually paralysis.…

Brivudine is a L-nucleoside analog of thymidine that exhibits antiviral, anticancer chemotherapeutic, and insecticidal activities. Brivudine inhibits herpes simplex virus (HSV-1) thymidine kinase, preventing DNA chain elongation and inhibiting viral growth. Brivudine also binds heat shock protein…

Cabozantanib is an anticancer chemotherapeutic compound that has been approved to treat medullary thyroid cancer and is in clinical trials as a treatment for other types of solid tumors. Cabozantanib exerts its anticancer activity through inhibition of Met, RET, and VEGFR2, increasing apoptosis and…

Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…

Chromostatin is a peptide fragment representing chromogranin A (124-143). Chromostatin exhibits cardiomodulatory activity, inhibiting vasoconstriction in thoracic arteries and saphenous veins induced by K+, norepinephrine, and endothelin-1. Additionally, chromostatin inhibits catecholamine…