Fluconazole is a subclass of the synthetic triazole antifungal agents. A highly selective inhibitor of fungal cytochrome P-450 sterol C-14 a-demethylation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.

Gentamicin is an aminoglycoside antibiotic complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is a mixture of 3 major components designated as C1, C1a, and C2. Gentamicin is used as the sulfate salt. Each component consists of five basic nitrogens and requires five…

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity. Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of…

Hygromycin B is an antibiotic substance isolated from Streptomyces hygroscopicus. Its mode of action is the inhibition of protein synthesis, by inducing the misreading of the m-RNA template in the prokaryote, (E. coli, at 100 mg/mL), lower eukaryotes (e.g., yeast, at 200 mg/mL) and higher…

Compound 48/80 is a oligomeric mixture of condensation products from N-methyl-p-methoxyphenethylamine and formaldehyde. It is a mixture of low-molecular weight polymers having a degree of polymerization between 3 to 6. Protein G activator similar to mastoparan. Calmodulin and platelet PLC…

Bleomycin is a mixture of basic antineoplastic antibiotics produced by glycopeptide produced by Streptomyces verticullus. Bleomycin binds to DNA and causes strand breaks. Bleomycin also inhibits incorporation thymidine into DNA strands. DNA cleavage by bleomycin depends on oxygen and metal ions, at…