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A fluorogenic substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4.
A synthetic amino acid derivative that acts as a specific agonist at the NMDA receptor, mimicking the excitatory action of the endogenous ligand glutamate.
Latanoprost is an F-series PG analog which has been approved for use as an ocular hypotensive drug. PG esters and other similar derivatives act as prodrugs which are converted to the active free acid form by an esterase/amidase activity in ocular tissues. The free acid form of Latanoprost is 200...
Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5’ to the abasic site to produce a single strand break. DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11...
An orally bioavailable inhibitor of sEH (IC50 = 0.33 µM) and agonist of PPARγ (EC50 of 0.3 µM); water soluble, orally bioavailable, and can be delivered through drinking water to upregulate PPARγ target genes.
An analog of resveratrol which potently induces apoptosis in HL-60 cells (IC50 = 40 nM versus 50 µM for resveratrol); induces apoptosis (IC50 = 30 nM) in HL-60R cells, a multidrug-resistant cell line derived from HL-60 cells.
AG-18 is an inhibitor of EGF receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431.
An antibiotic which binds the bacterial 50S ribosomal subunit and interferes with protein synthesis; effective against anaerobes and is commonly used against Gram positive bacteria.
A potent and selective inhibitor of cathepsin G (IC50 = 53 nM).
An inhibitor of non-structural protein 5A of hepatitis C virus; effectively reduces or eliminates certain genotypes of hepatitis C virus in vivo, particularly when used in combination with other agents.
Antigen: synthetic peptide corresponding to mouse IkBζ amino acids 684-699 and 285-298 Host: rabbit Cross Reactivity: (+) mouse IkBζ Application(s): WB IκBζ preferentially associates with the NF-κB subunit p50 rather than p65 and recombinant IκBζ proteins...
An inhibitor of the PTPs that blocks phosphorylation of CD45 and VHR (IC50s = 54 and 2 µM, respectively) and arrests cell cycle progress at the G1/S transition; also inhibits heparanase (IC50 = 17 µM), an endo-β-D-glucuronidase involved in tumor cell invasion...
An ATP-competitive, selective inhibitor of ALK (Ki = i = 0.7 nM) with strong activity against all known ALK and ROS1 mutants identified in patients; orally available with efficient blood-brain barrier penetration.
A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM.
An inhibitor of URAT1 (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption; also potently inhibits CYP2C9 (Ki = 20 nM) and has been used to study adverse drug-drug interactions.
A natural bicyclic depsipeptide that, following reduction, selectively inhibits class I HDACs (IC50s = 53, 39, 53, and 26 nM, for HDACs 1, 2, 3, and 8, respectively); has anti-cancer activities, particularly against certain T cell lymphomas.
A theoretical product of adrenic acid in the COX pathway; primarily produced in renal medulla where adrenic acid is selectively distributed.
A cyclic thioamide building block used in drug discovery chemistry.
A cell-permeable, nonpetidic nicotinoyl hydrazone that selectively suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity).
Source: recombinant protein expressed in Sf21 cells Mr: 54 kDa PPARs are members of the nuclear receptor family of ligand activated transcription factors that heterodimerize with retinoic acid like receptors, regulating gene expression and differentiation. PPARδ is a mediator of diverse...
A potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA; about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM; not a substrate for...
An isomer of a CYP450 metabolite of arachidonic acid that has no effect on proximal tubule ATPase activity.
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.
Immunogen: recombinant human mPGE synthase-1 Host: mouse, clone 6C6 Species Reactivity: (+) human mPGES-1 Application(s): WB