Cayman Chemical

A macrolide antibiotic that prevents the growth of M. haemolytica, P. multocida, and E. coli with MIC values of 2-4 µM; commonly used against respiratory infections in swine and cattle.

A small molecule inhibitor of Bcl-2 proteins (IC₅₀ = ~ 9 µM) that induces apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability).

A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.

A synthetic intermediate useful for pharmaceutical synthesis.

Arachidonamide is an analog of AEA that lacks the hydroxyethyl moiety. It is hydrolyzed by FAAH more effectively than AEA but exhibits significantly weaker binding to the human CB1 receptor with a Ki value of 9.6 µM. Arachidonamide and AEA exhibit similar binding and translocation into cells...

A small diffusible signaling molecule secreted by various bacteria; can have activating or suppressing effects on gene expression and biofilm formation, respectively; produced via lactonolysis from 3-oxooctanoyl-homoserine lactone.

A penicillanic acid sulfone that acts as an irreversible inhibitor of β-lactamases; effective against a wide variety of serine β-lactamases produced by common Gram-negative and Gram-positive aerobes and anaerobes.

A fungal metabolite which interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor; reduces both glucagon-stimulated cAMP production and glycogenolysis at 10 μM.

A 3,4-diaryl pyrazoloresorcinol compound that inhibits the Hsp90 ATPase activity with IC50 values of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively; induces Hsp72 expression and decreases the expression of oncogenic client proteins such as c-Raf, ErbB2, and Cdk4 in SKMEL 28...

Human therapeutic antibodies have become increasingly common components of early drug discovery and development portfolios in the pharmaceutical and biotech industries. As part of preclinical toxicology assessment of these agents, they are routinely tested in non-human primates, primarily in rhesus...

Molecular Formula: C₁₇H₁₂N₂O₂ Formula Weight: 276.3

A fluorescent cholesterol analog.

RD162 is a second-generation androgen receptor (AR) antagonist. It inhibits binding of 18 F-FDHT to AR in human prostate cancer cells with an IC₅₀ value of 30.9 nM. RD162 completely suppresses VCaP cell proliferation at 1 µM and induces apoptosis of VCaP cells at 10 µM. RD162...

Aspirin-d₄ is intended for use as an internal standard for the quantification of aspirin (Item No. 70260) by GC- or LC-MS. Aspirin is a non-selective, irreversible COX inhibitor. The IC₅₀ values for ovine COX-1 and -2 are 0.75 and 1.25 mM, respectively. Aspirin acetylates COX-1...

Cayman’s Autophagy/Cytotoxicity Dual Staining provides a convenient tool for studying the regulation of autophagy and cytotoxicity at the cellular level. The kit employs MDC, an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and the...

An internal standard for the quantification of hexadecanal by GC- or LC-MS.

A natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10 µM.

(±)17-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA can be produced by enzymatic oxidation of DHA using soybean LO and is the putative product of mammalian 15-LOs. 17(S)-HDHA is an...

A natural alkaloid that activates TRPV1 (EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM); inhibits MAOs (IC50s = 21 and 7 µM for MAO-A and MAO-B, respectively; inhibits CYP3A species (Ki ~ 5 µM) and increases expression of CYP1A and CYP2B in liver.

An inhibitor of Hsp70 (IC₅₀ = 0.5 µM) that is selective over Hsp90; binds the NBDs of Hsc70 (Ki = 10 µM) and Grp78 (KD = 80 nM); inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.

A selective MAP Kinase Kinase (MKK, MEK) inhibitor with IC₅₀ values of 72 and 58 nM for MEK1 and MEK2, respectively.

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC₅₀ values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl...

A diterpenoid compound that inhibits NF-κB binding to DNA promoters and induces expression of the CYP1A enzymes to produce immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, antiviral, antibacterial, antidiabetic, antioxidative stress, antipyretic, antiedematogenic, and...

A metabolite of (±)12(13)-EpOME.