Cayman Chemical

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

A form of biotin with a terminal azide group; is used to add biotin to other molecules that bear either an alkyne group, through click chemistry, or a phosphine group, using Staudinger ligation.

2,3-dinor-6-keto PGF1α is the β-oxidation product of 6-keto PGF1α and the major urinary metabolite of PGI2 in humans. 2,3-dinor-6-keto PGF1α makes up 23% of the recovered radioactivity in urine after administration of labeled 6-keto PGF1α and 20.5% after administration...

An orally active broad spectrum antifungal agent that blocks ergosterol biosynthesis by inhibiting the fungal CYP isoform CYP51; potently inhibits the mammalian analog CYP51A1 (IC₅₀ = 63.5 nM), as well as a variety of other CYP isoforms.

5(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 5(S)-HETE by GC- or LC-mass spectrometry (MS).

An internal standard for quantification of arachidonic acid methyl ester by GC- or LC-MS.

A cell-permeable form of cyclic PFT-α; 10-fold more active that PFT-α in protecting cortical neurons exposed to etoposide (ED₅₀ = 30 nM); not active in vivo.

A potent inhibitor of carbonic anhydrases (IC50s = 3.2 and 45.3 nM for CAII and CAIV, respectively) that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion.

A synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), with prominent selectivity for bacterial DHFR over mammalian DHFR (IC₅₀s = 5 and 30,000 nM, respectively); commonly used in combination with sulfamethoxazole to minimize acquired resistance.

An internal standard for the quantification of 5-iPF2α-VI by GC- or LC-MS.

An erlotinib analog characterized by the addition of a methyl group at the four position of the phenyl group.

An orally-bioavailable multi-kinase inhibitor that inhibits c-Raf, B-Raf, VEGFR1, VEGFR2, VEGFR3, Tie2, PDGFRβ, FGFR1, c-Kit, and RET with IC₅₀ values of 2.5, 28, 13, 4.2, 46, 311, 22, 202, 7, and 1.5 nM, respectively, as well as other kinases; also inhibits sEH (IC₅₀ =...

A selective, competitive, and highly bioavailable inhibitor of L-PGDS (Ki = 75 µM); inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse with an IC₅₀ value of 95 µM.

A melatonin receptor MT1 and MT2 agonist and competitive antagonist of human and porcine 5-HT2Creceptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).

A polyhydroxylated disaccharide acid that has antioxidant, chelating, and humectant properties; has numerous applications in the food, medicine, pharmaceutical, cosmetics, and chemical industries.

An analytical reference standard categorized as an oxidative quinone product of CBGA; intended for research and forensic applications

A RARβ agonist, RARα/γ antagonist that inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1 arrest; used to trigger the differentiation of mouse embryonic stem cells.

A water-soluble ester of the poorly soluble parent molecule, prednisolone; rapidly hydrolyzed in vivo to the parent molecule when administered intravenously; more readily absorbed than prednisolone when given orally.

A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively).

Immunogen: peptide from the C-terminal region of human BLT2 Host: rabbit Species Reactivity: (+) human and mouse BLT2 receptor Application(s): WB

An affinity probe which allows the HSL molecule to be detected or captured through an interaction with an avidin-containing probe.

Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in cellular membranes. It has been used in studies involving the biosynthesis of...

A selective adensosine A_2A receptor antagonist.

A natural triterpene which stimulates wound healing; induces cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 µM for MCF-7 cells); blocks angiogenesis in glioblastomas; down regulates BACE1 while increasing ADAM10 maturation in primary rat cortical neurons; protects against...