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A selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol; improves insulin sensitivity, lowers plasma, glucose and increases mitochondrial capacity in diet-induced obese and diabetic leptin-deficient ob/ob mice after one week of treatment with an oral dose of 100...
A selective activator of PKM2 (AC50 = 38 nM in vitro, EC50 = 19.6 µM in cells); converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins.
A nucleoside used in the biochemical synthesis of ribothymidine-3’-phosphate that has been used as a bioavailable source of uridine in research studies designed to enhance learning and memory.
A natural product with antibiotic, antifungal, and antimalarial properties; binds and inhibits heat shock protein 90 (HSP90) with nanomolar affinity.
A long-chain saturated fatty acid that does not affect plasma total cholesterol or LDL-cholesterol but may reduce HDL-cholesterol.
A naturally occurring analog of resveratrol that effectively scavenges H2O2, NO, and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (has neuroprotectant and depigmenting effects).
An internal standard for the quantification of 9-PAHSA by GC- or LC-MS.
Antigen: peroxynitrite-treated KLH Host: rabbit Application(s): WB The presence of nitrotyrosine on proteins can be used as a marker for peroxynitrite formation in vivo. Nitrotyrosine has been shown to be present in proteins from a variety of clinical conditions including artherosclerotic lesions of...
A C-7 truncated analog of LXA4 that is equiactive as LXA2 in the inhibition of LTB4-induced neutrophil chemotaxis (IC50 = 5 nM).
A naturally occuring terpenoid that potently inhibits MAGL (IC50 = 93 nM); at 1 µM, significantly inhibits endogenous MAGL in isolated rat neurons.
An anticoagulant; differs from (+)-warfarin by being five times more potent as a vitamin K antagonist; has a shorter terminal elimination half-life (24-33 hours) than (+)-warfarin (35-58 hours).
A 13-residue opioid peptide that acts as an endogenous κ1b-opioid receptor agonist (Ki = 1.1 nM); has been implicated in antinociceptive functions and has also been used to prime cardiogenesis in pluripotent embryonic stem cells.
S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase, microsomal epoxide hydrolase and porcine liver carboxylesterase. Hydrolysis of S-NEPC by sEH yields 4-nitrophenol which can be quantified spectrophotometrically at 405 nm. S-NEPC is...
TBS-Corey lactone aldehyde is a versatile, hydroxyl-protected intermediate for the synthesis of prostaglandins and prostaglandin analogs. Prostaglandin derivatives with modifications in the alpha chain, the omega chain, or both, are readily accessible from TBS-Corey aldehyde.
A cell-permeable inhibitor of ROCK (IC50 = 14 nM); reverses adrenalin-induced contraction of rat aortic rings (IC50 = 190 nM); produces a dose-dependent decrease in mean arterial pressure in spontaneously-hypertensive rats.
A selective EP1 antagonist that displays analgesic activity in mice (ED50 = 6.3 mg/kg when given subcutaneously) and in rats; inhibits the growth of glioma cell lines in vitro (IC50 = ~1 μM) and slows tumor growth in vivo; attenuates neuronal cell death in response to oxidative stress.
A third generation cephalosporin antibiotic that is effective against a variety of Gram-negative bacteria, including E. coli, K. pneumoniae, and H. influenzae (MIC values range from<0.025 to 25 µg l).<>
Nitration product of oleic acid in vivo mediated by peroxynitrite, acidified nitrite, or myeloperoxidase (in the presence of H2O2 and nitrite).
A non-enzymatic hydrolysis product of LTA4 with significantly reduced activity compared to LTB4.
A non-selective β-blocker/α1-blocker (Kis = 2.2 nM, 3.4 μM, and 0.81 nM for α1-, α2-, and β1-adrenoceptors, respectively; also activates cardioprotective signaling through β-arrestin and ERK1/2 activation (EC50 = 2 nM).
A Bcr-Abl kinase inhibitor (IC50 = 5.8 nM) that is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo; inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation; also targets the Src family kinase Lyn...
A β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM); commonly used with other antibiotics that would be inactivated by β-lactamases.
An analog of the PKC-activating second messengers collectively called DAG; equipotent to 1,2-dioctanoyl-sn-glycerol in induction of the acrosome reaction in human sperm.
A potent, selective inhibitor of HDAC6 (IC50 = 5.02 nM); dose-dependently induces hyperacetylation of α-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation.