1,1,1,3,3,3-Hexafluoro-2-propanol is polar and exhibits strong hydrogen bonding properties enabling it to dissolve substances that serve as hydrogen-bond acceptors. 1,1,1,3,3,3-Hexafluoro-2-propanol is a polar solvent of high ionizing power and facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalys. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.
It is a speciality solvent effective for solubilizing a wide range of polymers, including those that are not soluble in the most common organic solvents: such as polyamides, polyacrylonitriles, polyacetals, polyesters (e.g. polyglycolide), and polyketones. It has also found use in biochemistry to solubilize peptides and to monomerize β-sheet protein aggregates.It can be used as an acid in volatile buffers for ion pair HPLC - mass spectrometry of nucleic acids. 1,1,1,3,3,3-Hexafluoro-2-propanol was used for preparing hexafluoroalcohol-functionalized methacrylate polymers for lithographic/nanopatterning materials.
Key Applications: Solvent, Medicine
Application Areas: Molecular biology
Product Type: Biochemicals
Density: 1.62 g/mL
Boiling Point: 59°C (Lit.)
Melting Point: −4°C(lit.)
Refractive Index: n20/D 1.275(lit.)
Presentation: Clear Liquid
Detection Method: FTIR
Solubility: Miscibly soluble in water, 100 g/100 mL (25°C) (Lit.)
Storage & Handling: Store at Room Temperature (15-30°C)