Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Lidocaine is also an anasthetic and class Ib antiarrhythmic agent. This compund is known to block voltage-gated sodium channels in the inactivated state. Lidocaine is a second-generation antihistamine agent closely structurally related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine.
Lidocaine is used to treat allergies. It is generally used to differentiate and identify leucocytes, malaria parasites, and trypanosomas.
Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.
Key Applications: Cell Signaling, Neuroscience, Ion Channels
Application Areas: Molecular biology, Cell biology
Product Type: Biochemicals
Biochemical Category: Biochemicals
Boiling Point: 180°C(Lit.)
Melting Point: 66-69°C(Lit.)
Presentation: White Powder
Format: Powder
Solubility: Soluble to 100 mM in Ethanol.
Storage & Handling: Store at Room Temperature (15-30°C).