HT-22 is an immortalized mouse hippocampal cell line subcloned from the HT-4 cell line . The parental HT-4 cell line was derived from the immortalization of mouse neuronal tissues with a temperature sensitive SV40 T-antigen . HT-22 is highly sensitive to glutamate and is thus frequently used as a model system to study glutamate-induced toxicity in neuronal cells.
Synonyms: HT22 Cell Line
Application: Research CategoryNeuroscienceToxicity