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Potent, cell permeable inhibitor of PHD2 (IC50 = 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s > 100 μM); inhibits HIF-1α hydroxylation in RCC4 cells at 50 μM.