Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Atropine

    Cayman Chemical

    Non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8); increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine…

  • N-tetradecanoyl-L-Homoserine lactone

    Cayman Chemical

    A small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria; appears later than shorter chain AHLs in developing biofilms and, like other long chain AHLs, stimulates bacterial growth; alters proteolytic activity…

  • Roflumilast

    Cayman Chemical

    A potent, cell-permeable inhibitor of PDE4 (IC50 = 50 values against other PDE forms being greater than 10 μM.

  • ProClin™ 300

    MilliporeSigma

    ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

  • Cisplatin

    Cayman Chemical

    A platinum-containing compound that acts as an alkylating agent; used alone or in combination therapy in the treatment of several types of cancer; inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth.

  • Thapsigargin

    Cayman Chemical

    A non-competitive, cell permeable inhibitor of calcium transport by SERCAs (IC50 values are cell type-dependent and range from ~2-80 nM); increases intracellular calcium, leading to cell activation, histamine release, and increased cell proliferation; has anti-inflammatory and anti-cancer effects…

  • Combrestatin A4

    Cayman Chemical

    A potent inhibitor of tubulin polymerization with strong inhibitory activity on tumor cell growth.

  • Sodium Hydrogen Sulfide (hydrate)

    Cayman Chemical

    An H2S donor commonly used in cellular and whole animal experimental systems.

  • Sulforaphane

    Cayman Chemical

    An isothiocyanate that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression; at 15 μM, inhibits class I and II HDAC activity and suppresses tumor growth selectively in cancerous prostate epithelial cells without affecting normal cells.

  • N-cis-octadec-9Z-enoyl-L-Homoserine lactone

    Cayman Chemical

    A long-chain N-acylated HSL that functions as a quorum sensing signaling molecule.

  • Oleic Acid

    Cayman Chemical

    Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet…

  • HAMI3379

    Cayman Chemical

    A potent, selective CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >10, 000 nM, respectively.

  • Hoechst 33342 (hydrochloride)

    Cayman Chemical

    A cell-permeable, fluorescent probe for DNA that is useful as a marker of nuclei for cell cycle studies in combination with BrdU and to distinguish nuclear morphology in apoptotic cells.

  • Creatinine-d3

    Cayman Chemical

    An internal standard for the quantification of creatinine by GC- or LC-MS.

  • PGPC

    Cayman Chemical

    Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes and activate PMNL. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented,…

  • Aflatoxin B1

    Cayman Chemical

    Naturally occuring mycotoxin and food contaminant that induces the transversion of G to T at codon 249 of the p53 tumor suppressor gene and is a likely pathogen that causes hepatocellular carcinoma.

  • SKF-38393 (hydrobromide)

    Cayman Chemical

    SKF 38393 is a partial agonist of the dopamine D1-like receptors D1 and D5 (Kis = 1 and ~0.5 nM, respectively). It less potently binds D2, D3, and D4 receptors (Kis = ~150, 5,000, and 1,000 nM, respectively).

  • Sodium Chloride Stock Solution (5 M)

    Cayman Chemical

    Sodium chloride stock solution contains filtered sodium chloride (5 M). It is ready to use as supplied.

  • LE 135

    Cayman Chemical

    A RAR antagonist with moderate selectivity for RARβ over RARα (Kis = 0.22 and 1.4 μM, respectively); inhibits retinoid Am80-induced differentiatiobn of HL-60 cells (IC50 = 0.2 μM).

  • 10-Pyrene-PC

    Cayman Chemical

    10-Pyrene-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH. Upon phospholipid hydrolysis, 10-pyrenyldecanoic acid is produced from 10-pyrene-PC. The monomeric 10-pyrenyldecanoic acid exhibits fluorescence (excitation 345 nm, emission 395 nm), allowing quantitation of…

  • Bisdemethoxycurcumin

    Cayman Chemical

    A natural demethoxy derivative of curcumin; activates macrophage phagocytosis and, with 1α,25-dihydroxyvitamin D3, stimulates amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC); suppresses proliferation in cancer cells; down-regulates p300 and inhibits LPS-induced…

  • Magnesium Chloride Stock Solution (1 M)

    Cayman Chemical

    Magnesium chloride stock solution contains filtered magnesium chloride (1 M). It is ready to use as supplied.

  • Hoechst 33258

    Cayman Chemical

    A cell-permeable, fluorescent probe for DNA (ex. 352 nm/em. max 461 nm) that is useful as a marker of nuclei for cell cycle and to distinguish nuclear morphology in apoptotic cells.

  • A 83-01

    Cayman Chemical

    An inhibitor of ALK5, ALK4, and ALK7 (IC50s = 12, 45, and 7.5 nM, respectively); blocks the phosphorylation of Smad2/3 and inhibits TGF-β-induced epithelial-to-mesenchymal transition; used to reprogram fibroblasts into alternative lineages.

  • 22(R)-hydroxy Cholesterol

    Cayman Chemical

    An endogenous agonist for LXRα (EC50 = 325 nM) that can induce the expression of the ABCA1 reverse cholesterol transporter to inhibit the overall absorption of cholesterol; used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists.

  • Lutein

    Cayman Chemical

    A natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina; a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.

  • Tris-Acetate EDTA Stock Solution (50X, pH 8.0)

    Cayman Chemical

    Tris-acetate EDTA stock solution (50X, pH 8.0) contains a concentrated solution of filtered Tris-acetate EDTA (TAE) buffer.

  • Glycitein

    Cayman Chemical

    An O-methylated isoflavone with weak estrogenic activity (IC50 = 3.94 μM) that has been used in research related phytoestrogen therapeutic activity applied to bone formation, cardiovascular disease, estrogen-dependent cancer, and Alzheimer’s disease.

  • Retinoic Acid

    Cayman Chemical

    A metabolite of vitamin A that acts as a ligand for both the RAR and the RXR.

  • Stearidonic Acid ethyl ester

    Cayman Chemical

    An ester of the free acid that is less water soluble, but more amenable for the formulation of stearidonate-containing diets and dietary supplements.

  • Miltefosine-50 mg

    Cayman Chemical

    An inhibitor of CTP:phosphocholine cytidylyl transferase with antimetastatic properties.

  • 2-hydroxy-6-Methylbenzoic Acid

    Cayman Chemical

    A polyketide that serves as a precursor for many different antibiotic and anticancer agents.

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