Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • AS-1892802

    Cayman Chemical

    Formal Name: N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea CAS Number: 928320-12-1 Molecular Formula: C20H19N3O2

  • 17-phenyl trinor Prostaglandin F2a cyclohexyl amide

    Cayman Chemical

    A form of 17-phenyl trinor PGF modified with a cyclohexane moiety at the alpha carbon; insoluble in aqueous media, soluble in organic solvents; activity at the FP receptor has not been evaluated.

  • Trimesic Acid

    Cayman Chemical

    A planar benzoic acid used as a non-immunoglobin protein scaffold for studies of protein-protein interactions; also has various industrial uses in synthesizing adhesive and coating materials, plastics engineering, and as a pharmaceutical intermediate.

  • Leukotriene B4-3-aminopropylamide

    Cayman Chemical

    An analog of LTB4 that binds to the BLT1 and BLT2 receptors with Ki values of 5.1 and 1,227 nM, respectively.

  • JNJ-26854165

    Cayman Chemical

    An antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM); orally bioavailable, having anti-proliferation as well as apoptotic actions in various tumor models; affects multiple signaling pathways.

  • NCT-503

    Cayman Chemical

    A PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC50 = 2.5 µM); reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.

  • Capsaicin (technical grade)

    Cayman Chemical

    Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper. Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in…

  • Streptozotocin

    Cayman Chemical

    A glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA, leading to the destruction of beta cells.

  • 10-POHSA

    Cayman Chemical

    A FAHFA in which palmitoleic acid is esterified to 10-hydroxy stearic acid.

  • Suberohydroxamic Acid

    Cayman Chemical

    A competitive HDAC inhibitor that inhibits HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM); causes cell differentiation, cell cycle arrest, or apoptosis.

  • Fenofibric Acid

    Cayman Chemical

    A fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides; displays high affinity for L-FABP (Ki = 24 nM); exhibits EC50 values of 18 and 30 µM for murine and human PPARα, respectively, in a transactivation assay.

  • Amylose

    Cayman Chemical

    A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

  • Cholesterol

    LKT Labs

    Cholesterol is a sterol component of animal cell membranes that is required for membrane fluidity. Cholesterol is also the precursor to most steroid hormones, bile acids, and vitamin D compounds. Additionally, cholesterol is involved in vesicular transport and nerve conduction, and shows some…

  • Aflatoxin B2

    Cayman Chemical

    The dihydro derivative of Aflatoxin B1.

  • GW 9578

    Cayman Chemical

    A potent, selective PPARα agonist that activates murine and human PPARα with EC50 values of 0.005 and 0.05 µM, respectively; 0.2 mg/kg given orally once daily for three days decreased serum total LDL cholesterol 40-60% in male Sprague-Dawely rats.

  • 2-phenyl-3-methyl-Quinoxaline

    Cayman Chemical

    A synthetic intermediate useful for pharmaceutical synthesis.

  • Chlorogenic Acid

    Cayman Chemical

    Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean. Structurally, chlorogenic acid is the ester of caffeic acid with the 3-hydroxyl group of quinic acid. Chlorogenic acid is an important factor in plant metabolism.…

  • Colcemid

    Cayman Chemical

    A colchicine derivative that inhibits tubulin polymerization (IC50 = 2.1 μM) with low toxicity; suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase; used to synchronize cells and for karyotyping in cytogenetic studies.

  • Trigonelline (chloride)

    Cayman Chemical

    A pyridine alkaloid formed by the methylation of the nitrogen atom of niacin; used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes; inhibits the migration of hepatocarcinoma cells and renders them more susceptible to apoptosis by reducing Raf/ERK/Nrf2…

  • REV 5901

    Cayman Chemical

    REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 µM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 µM.

  • 1-Hexadecyl Lysophosphatidic Acid

    Cayman Chemical

    1-Hexadecyl lysophosphatidic acid is an ether analog of LPA containing a hexadecyl group at the sn-1 position. LPA binds to five different GPCRs to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.

  • L-a-Aminoadipic Acid

    Cayman Chemical

    A gliotoxic analog of the excitatory neurotransmitter glutamate that competitively inhibits glutamine synthetase (Ki = 209 µM); actively accumulates in glial cells and inhibits the glutamate transporter with a (Ki = 192 µM).

  • Ciglitazone

    Cayman Chemical

    An antidiabetic drug and selective PPARγ agonist (EC50 = 3.0 µM); active in vivo as an anti-hyperglycemic agent the ob/ob mouse model.

  • Trolox

    Cayman Chemical

    A cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties; commonly used as a standard or positive control in antioxidant assays.

  • Caffeine

    LKT Labs

    Caffeine is a xanthine alkaloid found in coffee, tea, and many other plant sources; it exhibits stimulant, bronchodilatory, anti-asthma, vasoconstrictive, anti-inflammatory, antioxidative, anti-aging, and anti-fibrotic activities. Caffeine activates adenosine receptors and inhibits…

  • Prostaglandin D2-1-glyceryl ester

    Cayman Chemical

    2-AG has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor. Incubation of 2-AG with COX-2 and specific PGH2 isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation. The…

  • Diphenhydramine (hydrochloride)

    Cayman Chemical

    A first generation antihistamine which is a potent antagonist of the human H1 receptor (Ki = 11.7 nM); readily crosses the blood-brain barrier and produces diverse cognitive and psychomotor effects; also antagonizes muscarinic cholinergic receptors (Ki = 100 to 260 nM for M1 through M5).

  • Tibolone

    Cayman Chemical

    Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.{12450} Three major metabolites of tibolone are responsible for its tissue selective mechanism of action.…

  • Guaiacol

    Cayman Chemical

    Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is readily oxidized by the heme iron of peroxidases including the peroxidase of COX enzymes. It can therefore serve as a reducing co-substrate for COX reactions. The one-electron oxidation…

  • Atropine

    Cayman Chemical

    Non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8); increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine…

  • Triphenylphosphine oxide

    Cayman Chemical

    A coordinating solvent used to activate crystallization of chemical compounds; used in flame retardant applications, as an epoxy cure catalyst, and to produce nanostructures.

  • tetranor-PGDM-d6

    Cayman Chemical

    An internal standard for the quantification of tetranor-PGDM by GC- or LC-MS.

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