Biologically Active Small Molecules

Compare Tool

Select up to 3 products

HomeAll Products

Biologically Active Small Molecules

1 - 32 of 6575
Sort
View
Show
  • Leukotriene B4-3-aminopropylamide

    Cayman Chemical

    An analog of LTB4 that binds to the BLT1 and BLT2 receptors with Ki values of 5.1 and 1,227 nM, respectively.

  • 3-Thiatetradecanoic Acid

    Cayman Chemical

    3-thia TDA is an analog of the 14-carbon saturated fatty acid myristic acid, wherein the C-3 carbon has been replaced by sulfur in a thioether linkage. When chronically administered to rats, 3-thia TDA acts as a peroxisome inducer (PPAR ligand), increases fatty acid oxidation, and lowers plasma…

  • CAY10577

    Cayman Chemical

    A CK2 inhibitor with an IC50 value of 0.8 µM.

  • AS-1892802

    Cayman Chemical

    Formal Name: N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea CAS Number: 928320-12-1 Molecular Formula: C20H19N3O2

  • Vancomycin (hydrochloride)

    Cayman Chemical

    A glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci; binds to bacterial cell wall precursors, interfering with their synthesis.

  • (-)-Epicatechin Gallate

    Cayman Chemical

    A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus.

  • Amylose

    Cayman Chemical

    A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

  • Lomeguatrib

    Cayman Chemical

    A modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM).

  • NADP+ (sodium salt hydrate)

    Cayman Chemical

    The oxidized form of NADPH; serves as a cofactor in various biological reactions.

  • 10-POHSA

    Cayman Chemical

    A FAHFA in which palmitoleic acid is esterified to 10-hydroxy stearic acid.

  • Pioglitazone (potassium salt)

    Cayman Chemical

    Thiazolidinediones (TZDs) are a group of structurally related PPARγ agonists with anti-diabetic actions in vivo. Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class of PPARγ ligands. Pioglitazone is a closely related TZD which also…

  • 8,12-iso-iPF2a-VI

    Cayman Chemical

    The most abundant isoprostane product formed during lipid peroxidation; detected after CCl4-induced oxidative damage to hepatic tissue and has been found elevated in the urine, blood, and CSF of patients with Alzheimer’s disease.

  • AZD 7762

    Cayman Chemical

    Selectively inhibits checkpoint kinases Chk1 and Chk2 (IC50s = 5 nM); abrogates DNA damage-induced S and G2 checkpoints (EC50 = 10 nM) and potentiates the efficacy of gemcitabine and topotecan by modulating downstream checkpoint pathway proteins.

  • NVP-BSK805 (hydrochloride)

    Cayman Chemical

    A potent inhibitor of JAK2 that also inhibits the JAK2V617F mutant enzyme (IC50s for both enzymes ~ 0.5 nM); orally bioavailable with a long half-life in vivo, suppressing leukemic cell spreading and splenomegaly in JAK2V617F cell-driven disease in mice.

  • HAMI3379

    Cayman Chemical

    A potent, selective CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >10, 000 nM, respectively.

  • Ibuprofen

    Cayman Chemical

    A non-selective, reversible COX inhibitor. with IC50 values for human recombinant COX-1 and -2 at 2.6 and 1.53 µM, respectively; Ki values for ovine COX-1 and -2 are both 9 µM.

  • SAMS Peptide

    Cayman Chemical

    A selective substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase.

  • GSK5959

    Cayman Chemical

    A potent, selective, and cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM); disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3.

  • Phleomycin

    Cayman Chemical

    A glycopeptide antibiotic that causes DNA fragmentation; used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.

  • REV 5901

    Cayman Chemical

    REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 µM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 µM.

  • GW 9578

    Cayman Chemical

    A potent, selective PPARα agonist that activates murine and human PPARα with EC50 values of 0.005 and 0.05 µM, respectively; 0.2 mg/kg given orally once daily for three days decreased serum total LDL cholesterol 40-60% in male Sprague-Dawely rats.

  • CH5132799

    LKT Labs

    CH5132799 is an inhibitor of PI3K that is somewhat selective for p110a isoforms. This compound exhibits anticancer chemotherapeutic activity, inhibiting cell proliferation and tumor growth in breast cancer, ovarian cancer, prostate cancer, and endometrial cancer models.

  • GW 6471

    Cayman Chemical

    An antagonist of PPARα (IC50 = 240 nM), promoting the recruitment of co-repressor proteins; used in cell-free, cell lysate, and whole cell systems.

  • Echinomycin

    Cayman Chemical

    A cell-permeable inhibitor of HIF-1-mediated gene transcription which acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the HRE; reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50…

  • Methotrexate, USP and EP Grade

    MP Biomedicals

    Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of…

  • ProClin™ 300

    MilliporeSigma

    ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

  • COX Inhibitor Pack

    Cayman Chemical

    The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype nonselective, irreversible COX inhibitor. A series of COX-2 selective inhibitors are available in the COX-PAK, including NS-398, one of the first…

  • tetranor-PGDM-d6

    Cayman Chemical

    An internal standard for the quantification of tetranor-PGDM by GC- or LC-MS.

  • n-Propyl Gallate

    MP Biomedicals

    n-Propyl gallate is an ester formed by the condensation of gallic acid and propanol. This antioxidant has been added to foods containing oils and fats to prevent oxidation. n-Propyl gallate is used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes…

  • Saline Sodium Phosphate EDTA Stock Solution (20X, pH 6.5)

    Cayman Chemical

    Saline sodium phosphate EDTA stock solution (20X, pH 6.5) contains a concentrated solution of filtered saline sodium phosphate EDTA (SSPE) buffer.

  • 13-Docosenamide

    Cayman Chemical

    An amide of docosenoic acid first identified in the CSF of sleep-deprived cats; causes reduced mobility and slightly lessened awareness in rats.

  • Thiostrepton

    Cayman Chemical

    A natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes; prevents proliferation and induces apoptosis in human cancer cells; also acts as a proteasome inhibitor.

Compare Tool

Select up to 3 products

Please Log In

Don't have an Account? Create one now.