Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Aflatoxin M1

    LKT Labs

    Aflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin M1 is the hydroxylated metabolite of aflatoxin B1; it inhibits DNA synthesis and induces cell cycle arrest.

  • Tigecycline

    Cayman Chemical

    A glycylcycline antibiotic with a broad spectrum of activity against many Gram-positive, Gram-negative, and anaerobic organisms, including many multidrug-resistant strains.

  • Resazurin (sodium salt)

    Cayman Chemical

    A blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or…

  • Suberohydroxamic Acid

    Cayman Chemical

    A competitive HDAC inhibitor that inhibits HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM); causes cell differentiation, cell cycle arrest, or apoptosis.

  • ProClin™ 300

    MilliporeSigma

    ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

  • D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)

    Cayman Chemical

    D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release…

  • Sulfaphenazole

    Cayman Chemical

    Selective inhibitor of CYP2C9 (Ki = 0.3 μM); inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

  • Caylin-2

    Cayman Chemical

    A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~8 µM); promotes the growth of HCT116 cells ~40% at concentrations between 5-100 nM.

  • Vitamin B12

    Cayman Chemical

    A corrinoid vitamin with roles in brain and nervous system functioning and blood formation through regulation of DNA synthesis, cellular metabolism, fatty acid metabolism, and amino acid metabolism; serves as a cofactor in isomerase-, methyltransferase-, and dehalogenase-catalyzed reactions,…

  • Trolox

    Cayman Chemical

    A cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties; commonly used as a standard or positive control in antioxidant assays.

  • Aflatoxin B1

    Cayman Chemical

    Naturally occuring mycotoxin and food contaminant that induces the transversion of G to T at codon 249 of the p53 tumor suppressor gene and is a likely pathogen that causes hepatocellular carcinoma.

  • Butylated Hydroxytoluene

    LKT Labs

    Butylated hydroxytoluene (BHT) is commonly used as a food and cosmetics additive; it exhibits antioxidative and anti-inflammatory activities. BHT may also display neuroprotective benefit, decreasing ethanol-induced brain damage and neurodegeneration and suppressing activation of NF-?B activation…

  • Lecithin from Egg

    MP Biomedicals

    Lecithin is the major membrane phospholipid in eukaryotic cells. In addition to being the major structural component of cellular membranes, it serves as a reservoir for several lipid messengers. It is the source of the bioactive lipids lysophosphatidylcholine, phosphatidic acid, diacylglycerol,…

  • Clenbuterol (hydrochloride)

    Cayman Chemical

    A sympathomimetic β2-adrenoceptor agonist that relaxes bronchial smooth muscle and at higher doses acts as an anabolic steroid, promoting skeletal muscle protein synthesis.

  • (-)-Gallocatechin

    Cayman Chemical

    An epimer of (−)-EGC and potent antioxidant; significantly inhibits the proliferation of HCT116 and SW-480 cancer cells; inhibits the aggregation of amyloid β peptide in vitro (IC50 = 17.5 µM).

  • Fenofibric Acid

    Cayman Chemical

    A fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides; displays high affinity for L-FABP (Ki = 24 nM); exhibits EC50 values of 18 and 30 µM for murine and human PPARα, respectively, in a transactivation assay.

  • Pyocyanin

    Cayman Chemical

    Activates the aryl hydrocarbon receptor (Ki = 5.4 µM), inducing the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria; accelerates neutrophil apoptosis, resulting in resolution of acute inflammation.

  • ML314

    Cayman Chemical

    Molecular Formula: C24H28N4O3

  • HAT Inhibitor II

    Cayman Chemical

    A cell-permeable, selective inhibitor of the HAT p300 (IC50 = 5 µM).

  • Clavulanate (potassium salt)

    Cayman Chemical

    A β-lactamase inhibitor that is effective against Ambler class A β-lactamases (IC50 values range from 12 to 60 nM); commonly used with other antibiotics that would be inactivated by β-lactamases.

  • Single-Use Eicosapentaenoic Acid (peroxide free)

    Cayman Chemical

    Single-use eicosapentaenoic (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use…

  • Daidzein-d4

    Cayman Chemical

    CAS Number: 1219803-57-2 Synonyms: Isoflavone-d4 Molecular Formula: C15H6D4O4 Formula Weight: 258.3

  • Pyrazine-2-amidoxime

    Cayman Chemical

    A synthetic intermediate for pharmaceutical synthesis.

  • Bizine

    Cayman Chemical

    An LSD1 inhibitor.

  • Cafestol Acetate

    LKT Labs

    Cafestol is a diterpene initially found in brewed, unfiltered coffee that exhibits anti-angiogenic, anticancer, chemopreventive, neuromodulatory, anti-inflammatory, and hyperlipidemic activities. Cafestol inhibits proliferation, migration, and tube formation in vitro, potentially through decreasing…

  • AEM1

    Cayman Chemical

    An inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 µM; sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitro and in vivo in animals.

  • Amylose

    Cayman Chemical

    A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

  • Vildagliptin

    Cayman Chemical

    An inhibitor of DPP-4 (IC50 = 3.5-34 nM); also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or FAPα; blocks the degradation of several circulating peptides, including incretins; reduces fasting and postprandial glucose levels and decreases inflammatory…

  • Zilpaterol

    Cayman Chemical

    A β-adrenergic receptor agonist that putatively through activation of protein kinase A increases protein synthesis in skeletal muscle fibers, as well as reduces lipogenesis and increases lipolysis in adipose tissues; used as a veterinary food additive to increase lean body weight in commercial…

  • RIPA Buffer Concentrate

    Cayman Chemical

    10ml of 250 mM Tris-HCl, pH 7.6, containing 750 mM sodium chloride, 5% NP-40, 2.5% sodium deoxycholate, and 0.5% SDS

  • Ochratoxin A

    Cayman Chemical

    A mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,…

  • Phloxine B

    Cayman Chemical

    A red dye that can be used as an alternative to Gram staining; inhibits MRSA growth in vitro at 100 µg/ml; modulates channel activity of wild-type CFTR (Ki = 38 µM) and mutant delta F508 CFTR (Ki = 33 µM).

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