Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • Aprotinin

    Cayman Chemical

    A reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM); widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.

  • Tris-HCl Stock Solution (1 M, pH 8.0)

    Cayman Chemical

    Tris-HCl Stock Solution (1 M, pH 8.0) contains filtered Tris-HCl (1 M, pH 8.0). It is ready to use as supplied.

  • Butylated Hydroxytoluene

    LKT Labs

    Butylated hydroxytoluene (BHT) is commonly used as a food and cosmetics additive; it exhibits antioxidative and anti-inflammatory activities. BHT may also display neuroprotective benefit, decreasing ethanol-induced brain damage and neurodegeneration and suppressing activation of NF-?B activation…

  • (+)-Catechin (hydrate)

    Cayman Chemical

    Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid…

  • 2,4-DPD

    Cayman Chemical

    A cell permeable, competitive inhibitor of HIF-PH with effective concentrations in the low µM range.

  • Kaempferol

    Cayman Chemical

    A dietary flavonoid which has diverse physiological activities through both direct and indirect effects; directly binds ERα and ERβ, acting as an inverse agonist or agonist; acts as an antioxidant; suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.

  • 2-HBA

    Cayman Chemical

    A synthetic analog of curcumin that activates enzymes which catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway; increases NQO1 activity, glutathione reductase activity, and total glutathione levels in vitro at 0.6 – 0.15 μM; causes G2/M cell cycle arrest and…

  • TGX-221

    Cayman Chemical

    A potent, selective, and cell permable inhibitor of PI3K p110b; IC50 value increases from 5 to ~50 nM at ATP concentrations of 50 µM and 1 mM, respectively; inhibits PtdIns-(3,4)-P2 production in platelets with an IC50 value of 50 nM.

  • Glycerol Stock Solution (20% v/v)

    Cayman Chemical

    Glycerol stock solution (20% v/v) contains 20% glycerol. It is ready to use as supplied.

  • IPTG (dioxane free)

    Cayman Chemical

    Induces protein expression where the gene is under the control of the lac operator by triggering transcription of the lac operon in cloning procedures.

  • Oleic Acid

    Cayman Chemical

    Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet…

  • L-Citrulline

    LKT Labs

    L-Citrulline is a by product of NO formation from metabolism of L-arginine that exhibits tocolytic and antioxidative activities. L-Citrulline was originally found in watermelon. In isolated rat uteri, L-citrulline decreases uterine contractile force through stimulation of the NO-cGMP relaxant…

  • Curcumin (technical grade)

    Cayman Chemical

    Curcumin is an extract of turmeric root with antioxidant, anti-tumor, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages.

  • Bilirubin from Porcine Gall Bladder

    MP Biomedicals

    Bilirubin is the principal pigment of bile and constituent of many biliary calculi and also found in blood. As the major end-product of the biological breakdown of heme, bilirubin is the chromophore responsible for coloration in various forms of jaundice. Bilirubin is suitable for use in the…

  • Prostaglandin E1

    Cayman Chemical

    PGE1 is the theoretical COX metabolite of DGLA, but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet…

  • Quinacrine (hydrochloride hydrate)

    Cayman Chemical

    An anti-protozoal agent; prevents misfolding of prion protein (EC50 = 0.3 μM), blocks voltage-dependent sodium channels (IC50 = 3.3 μM), inhibits aldehyde oxidase (IC50 = 3.3 μM), antagonizes the riboflavin-binding protein (Ki = 6.7 μM), inhibits…

  • CP 673,451

    Cayman Chemical

    A selective inhibitor of PDGFRβ and PDGFRα kinases (IC50s = 1 and 10 nM, respectively); antiangiogenic and antitumor activity in several in vivo tumor models.

  • Coelenterazine h

    Cayman Chemical

    A synthetic derivative of native coelenterazine that exhibits 16-fold higher luminescence intensity (emission maximum ~466 nm; half-total time of 0.6-1.2 sec) than native coelenterazine.

  • VER-50589

    Cayman Chemical

    An isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM; produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel.

  • Sumatriptan (succinate)

    Cayman Chemical

    A serotonin 5-HT1B and 5-HT1D receptor agonist (IC50s = 9.3 and 7.3 nM, respectively) that also has affinity for the 5-HT1F receptor (IC50 = 17.8 nM); constricts human middle meningeal arteries (EC50 = 89.9 nM) and reduces vascular inflammation associated with migraines.

  • Auraptene

    Cayman Chemical

    A coumarin derived from citrus plants with anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities; inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.

  • L-Sulforaphane

    Cayman Chemical

    An isothiocyanate derived from glucoraphanin; powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects; at 40 µM, activates Nrf2-mediated gene expression of phase II detoxification enzymes by disrupting the Keap1-Nrf2 complex, allowing Nrf2 to alter transcription.

  • Pyronin Y

    Cayman Chemical

    A fluorescent probe which stains dsRNA in living or fixed cells as well as in tissues; amenable to FC; maximum excitation is at 540-550 nm, with maximum emission at 560-580 nm.

  • Bisdemethoxycurcumin

    Cayman Chemical

    A natural demethoxy derivative of curcumin; activates macrophage phagocytosis and, with 1α,25-dihydroxyvitamin D3, stimulates amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC); suppresses proliferation in cancer cells; down-regulates p300 and inhibits LPS-induced…

  • Forskolin

    Cayman Chemical

    A naturally occurring diterpene that directly activates adenylyl cyclase to raise levels of cAMP in a wide variety of cell types; binds to type 1 adenylyl cyclase membranes with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay.

  • Palmitic Acid

    Cayman Chemical

    A common 16-carbon saturated fatty acid that represents 10-20% of the normal human dietary fat intake.

  • Coomassie Blue R-250

    Cayman Chemical

    A dye that is commonly used in laboratories to stain or quantify proteins; typically gives blue bands on a clear background with a sensitivity of 50-100 ng/band; displays metachromasia by appearing pink-red, rather than blue, when binding certain proteins, such as collagen and histone H1.

  • 22(R)-hydroxy Cholesterol

    Cayman Chemical

    An endogenous agonist for LXRα (EC50 = 325 nM) that can induce the expression of the ABCA1 reverse cholesterol transporter to inhibit the overall absorption of cholesterol; used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists.

  • L-DOPA

    Cayman Chemical

    A metabolic precursor of dopamine that crosses the blood brain barrier; used to treat Parkinson’s disease and stroke damage.

  • Fura-PE3 AM

    Cayman Chemical

    The AM of fura-PE3, a non-invasive, intracellular calcium indicator that is UV light-excitable; resists the rapid leakage and compartmentalization seen with fura-2.

  • Vitamin B12

    Cayman Chemical

    A corrinoid vitamin with roles in brain and nervous system functioning and blood formation through regulation of DNA synthesis, cellular metabolism, fatty acid metabolism, and amino acid metabolism; serves as a cofactor in isomerase-, methyltransferase-, and dehalogenase-catalyzed reactions,…

  • Amylose

    Cayman Chemical

    A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

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