A potent, selective, and cell-permeable inhibitor of the BRPF1 bromodomain (IC₅₀ = 80 nM); disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3.

A synthetic intermediate useful for pharmaceutical synthesis.

A synthetic intermediate useful for pharmaceutical synthesis.

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID), derived from naproxen but coupled to an H₂S-releasing moiety. At 30 µmol/kg in rats, it suppressed COX and gastric PGE₂ synthesis to the same level as naproxen but reduced COX-2 expression and accelerated…

An orally available inverse agonist of PPARβ/δ (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM).

Potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells (IC50 = ~0.5 µM); activates NF-κB via PKC and downregulates HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

A potent, selective PPARα agonist that activates murine and human PPARα with EC50 values of 0.005 and 0.05 µM, respectively; 0.2 mg/kg given orally once daily for three days decreased serum total LDL cholesterol 40-60% in male Sprague-Dawely rats.

REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 µM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC₅₀ value of 0.12 µM.

An N-substituted 1,8-naphthalimide used as a fluorescent probe for various studies and as a precursor for protection of amine groups.

A FAHFA in which palmitoleic acid is esterified to 10-hydroxy stearic acid.

An analog of LTB4 that binds to the BLT1 and BLT2 receptors with Ki values of 5.1 and 1,227 nM, respectively.

A competitive α1- and α2-adrenergic receptor antagonist with peripheral vasodilator and histamine-like effects in animal models.

An elongation product of γ-linolenic acid (18:3), rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4); metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins; can reduce atopic dermatitis and atherosclerosis when added to the diet of mice.

CAS Number: 745046-84-8 Synonyms: Ivachtin Molecular Formula: C₂₀H₂₁N₃O₇S

The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM)…

An amide of docosenoic acid first identified in the CSF of sleep-deprived cats; causes reduced mobility and slightly lessened awareness in rats.

A glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci; binds to bacterial cell wall precursors, interfering with their synthesis.

A well-characterized natural advanced glycation end (AGE) that is often used as a biomarker for the production of all AGEs.

A cell-permeable, selective SIRT1 inhibitor (IC₅₀ = 0.7-2 µM) that reactivates p53 by inhibiting SIRT1 deacetylation activity; inhibits cell proliferation by inducing p53-dependent apoptosis in various human cancer cells (IC₅₀s = 5.4, 51.9, 3.2, 33.9, and 85.4 µM…

Capsaicin is an agonist of transient receptor potential vanilloid (TRPV) channels that was originally found in peppers of the Capsicum genus. Capsaicin exhibits analgesic, anti-inflammatory, anti-obesity, and anticancer chemotherapeutic activity. Capsaicin also displays bronchoconstrictive activity…

One of two cyclic forms of D-glucose that is the monomer unit in cellulose.

The dihydro derivative of Aflatoxin B1.

ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

A cell-permeable inhibitor of HIF-1-mediated gene transcription which acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the HRE; reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50…

An acyclic sesquiterpenoid that regulates diverse processes in insects; activates the juvenile hormone receptor, known as methoprene-tolerant, with a Kd value of 2.9 nM.

A triazole antifungal agent that is effective against most Candida strains.

Apigenin is a flavonoid found in various plant sources that exhibits anticancer, antioxidative, anti-inflammatory, cognition enhancing, and neuroprotective activities. In gastric cancer cells, apigenin inhibits cell proliferation, decreases mitochondrial membrane potential, increases expression of…

A carbamate pesticide that reversibly inhibits acetylcholinesterase.

PGE1 is the theoretical COX metabolite of DGLA, but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC₅₀ of PGE1 for the inhibition of ADP-induced human platelet…

A potent group IVA cPLA2 inhibitor (XI(50) = 0.022); reduces thermal hyperalgesia evoked by carrageenan injection of rat hind paw (ED₅₀ = 1.2 mg/kg); does not inhibit COX activity or interfere with CB1 receptor signaling.

A loop diuretic with good absorption and pharmacodynamic properties; acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively).

Aristolochic acid C is a carcinogenic compound found in Aristolochia and Radix that has commonly been used in traditional Chinese medicine.