An analog of LTB4 that binds to the BLT1 and BLT2 receptors with Ki values of 5.1 and 1,227 nM, respectively.

3-thia TDA is an analog of the 14-carbon saturated fatty acid myristic acid, wherein the C-3 carbon has been replaced by sulfur in a thioether linkage. When chronically administered to rats, 3-thia TDA acts as a peroxisome inducer (PPAR ligand), increases fatty acid oxidation, and lowers plasma…

A CK2 inhibitor with an IC50 value of 0.8 µM.

Formal Name: N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea CAS Number: 928320-12-1 Molecular Formula: C₂₀H₁₉N₃O₂

A glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci; binds to bacterial cell wall precursors, interfering with their synthesis.

A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus.

A polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.

A modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM).

The oxidized form of NADPH; serves as a cofactor in various biological reactions.

A FAHFA in which palmitoleic acid is esterified to 10-hydroxy stearic acid.

Thiazolidinediones (TZDs) are a group of structurally related PPARγ agonists with anti-diabetic actions in vivo. Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class of PPARγ ligands. Pioglitazone is a closely related TZD which also…

The most abundant isoprostane product formed during lipid peroxidation; detected after CCl4-induced oxidative damage to hepatic tissue and has been found elevated in the urine, blood, and CSF of patients with Alzheimer’s disease.

Selectively inhibits checkpoint kinases Chk1 and Chk2 (IC50s = 5 nM); abrogates DNA damage-induced S and G2 checkpoints (EC50 = 10 nM) and potentiates the efficacy of gemcitabine and topotecan by modulating downstream checkpoint pathway proteins.

A potent inhibitor of JAK2 that also inhibits the JAK2V617F mutant enzyme (IC₅₀s for both enzymes ~ 0.5 nM); orally bioavailable with a long half-life in vivo, suppressing leukemic cell spreading and splenomegaly in JAK2V617F cell-driven disease in mice.

A potent, selective CysLT2 receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >10, 000 nM, respectively.

A non-selective, reversible COX inhibitor. with IC₅₀ values for human recombinant COX-1 and -2 at 2.6 and 1.53 µM, respectively; Ki values for ovine COX-1 and -2 are both 9 µM.

A selective substrate for AMPK based on the sequence around Ser79 on acetyl-CoA carboxylase.

A potent, selective, and cell-permeable inhibitor of the BRPF1 bromodomain (IC₅₀ = 80 nM); disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3.

A glycopeptide antibiotic that causes DNA fragmentation; used, in conjunction with a vector carrying the bleomycin resistance protein ble, as a selective agent in the transformation of yeast, plant cells, and mammalian cells.

REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 µM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC₅₀ value of 0.12 µM.

A potent, selective PPARα agonist that activates murine and human PPARα with EC50 values of 0.005 and 0.05 µM, respectively; 0.2 mg/kg given orally once daily for three days decreased serum total LDL cholesterol 40-60% in male Sprague-Dawely rats.

CH5132799 is an inhibitor of PI3K that is somewhat selective for p110a isoforms. This compound exhibits anticancer chemotherapeutic activity, inhibiting cell proliferation and tumor growth in breast cancer, ovarian cancer, prostate cancer, and endometrial cancer models.

An antagonist of PPARα (IC50 = 240 nM), promoting the recruitment of co-repressor proteins; used in cell-free, cell lysate, and whole cell systems.

A cell-permeable inhibitor of HIF-1-mediated gene transcription which acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the HRE; reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50…

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of…

ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high…

The Cayman COX Inhibitor Pack contains a combination of frequently used cyclooxygenase (COX) inhibitors. Each kit contains aspirin, the archetype nonselective, irreversible COX inhibitor. A series of COX-2 selective inhibitors are available in the COX-PAK, including NS-398, one of the first…

An internal standard for the quantification of tetranor-PGDM by GC- or LC-MS.

n-Propyl gallate is an ester formed by the condensation of gallic acid and propanol. This antioxidant has been added to foods containing oils and fats to prevent oxidation. n-Propyl gallate is used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes…

Saline sodium phosphate EDTA stock solution (20X, pH 6.5) contains a concentrated solution of filtered saline sodium phosphate EDTA (SSPE) buffer.

An amide of docosenoic acid first identified in the CSF of sleep-deprived cats; causes reduced mobility and slightly lessened awareness in rats.

A natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes; prevents proliferation and induces apoptosis in human cancer cells; also acts as a proteasome inhibitor.