A broad spectrum inhibitor of MMPs, with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14; also potently inhibits TACE (IC50 = 14.9 nM); has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.