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Separation Methods Technologies

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  • Elite Series Reversed-Phase C18 Columns

    Separation Methods Technologies

    Elite-C18 Series: SMT SAM-C18 phases with the intermediate functional ligand coverage confirmed with carbon analysis results of 16% carbon load. In these series, the density of the functional ligand, octadecyl molecule or C18, is moderated with the proprietary spacer molecule to ensure maximum…

  • Bulk Diol 2

    Separation Methods Technologies

    SMT-Diol bulk packings are developed as an alternative for silica bulk packings used in separation methods. The Diol [-OH] functional group is controlled, and as such, provides more reproducible separation when compared to separation on silanols [-OH] from bare silica surface. Furthermore, the…

  • SEC/GPC Columns

    Separation Methods Technologies

    SMTgel (silica-based) columns are specialty SMT columns designed for specific applications including gel permeation (GPC), ion exchange, reversed phase, hydrophobic interaction, hydrophilic interaction, and affinity chromatography. The packing materials feature modified surface chemistry…

  • Bulk C18

    Separation Methods Technologies

    SMT manufactures the most reliable silica based octadecyl (C18) column available in the market today. This advanced new column is very stable at a wide pH range and high temperatures. SMT utilizes a proprietary bonding scheme that allows the resulting bonded phases to perform separation of basic,…

  • Specialty Chiral 1 Columns

    Separation Methods Technologies

    Chiral compounds, or enantiomers have identical molecular structures that are related as mirror images of one another much like a left hand is related to a right hand. Rapid and accurate stereochemical resolution of enantiomeric molecules has become a challenge in various aspects of pharmaceuticals…

  • Normal Phase Silica Columns

    Separation Methods Technologies

    When silica is used as the stationary phase, the functional groups involved in separation are the surface silanols. However, metal impurities in silica may provide additional sites of interaction for solutes of interest. SMT uses high purity silica packing materials that are available in variety of…

  • Bulk C2

    Separation Methods Technologies

    SMT manufactures bulk packings with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation of the…

  • Specialty CIB-ProteinA Columns

    Separation Methods Technologies

    SMT CIB-ProteinA are silica-based packing materials de- signed for both high performance and low-pressure purification of antibodies, IgG. In production of the ProteinA affinity-type columns, SMT utilizes its proprietary technique of self-assembled monolayer (SAM) of bonding to first immobilize…

  • Normal Phase Cyanopropyl Columns

    Separation Methods Technologies

    SMT manufactures ultra-stable cyanopropyl [CN] columns for normal and reversed-phase chromatographic separation modes. These columns have some special characteristics. When used in normal phase mode, with relatively nonpolar solvents, CN-stationary phase can separate many polar compounds just like…

  • Ion-Exchange SAX Columns

    Separation Methods Technologies

    SMT-SAX columns are silica-based Strong Anion eXchange packing developed for separation of anionic compounds. SMT-SAX packings consist of chemically attached hydrophilic surface derivatized to form quaternary amine. The technique of SAM is used in the bonding process to significantly increase the…

  • Bulk C4

    Separation Methods Technologies

    SMT manufactures bulk packings with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation of the…

  • Elite Series Reversed-Phase C8 Columns

    Separation Methods Technologies

    Elite-C18 Series: SMT SAM-C18 phases with the intermediate functional ligand coverage confirmed with carbon analysis results of 16% carbon load. In these series, the density of the functional ligand, octadecyl molecule or C18, is moderated with the proprietary spacer molecule to ensure maximum…

  • Bulk DEAE

    Separation Methods Technologies

    SMT-DEAE [Di-Ethyl-Amino-Ethyl] column provides a unique chemically attached hydrophilic, weak anion exchange type, functional surface desirable for the separation of many biomolecules such as proteins, nucleotides, oligonucleotides, polynucleotides, high molecular weight RNA’s and plasmid…

  • Ion-Exchange DEAE Columns

    Separation Methods Technologies

    SMT-DEAE [Di-Ethyl-Amino-Ethyl] column provides a unique chemically attached hydrophilic, weak anion exchange type, functional surface desirable for the separation of many biomolecules such as proteins, nucleotides, oligonucleotides, polynucleotides, high molecular weight RNA?s and plasmid DNA?s.…

  • Reversed-Phase C5 Columns

    Separation Methods Technologies

    SMT SAM-C5 columns consist of Pentyl as the functional ligand. The columns offer selectivities that are different from C8 and C18 reversed-phase columns when applied to separation of polyaromatic hydrocarbons. SMT-C5 columns are specially designed as complementary alternatives for the separation…

  • Ion-Exchange WAX Columns

    Separation Methods Technologies

    SMT-WAX columns are silica-based Weak Anion eXchange packing materials developed for separation of anionic compounds. SMT-WAX consists of chemically attached hydrophilic surface derivatized to form polyethyleneimine functionality. The technique of SAM is used in the bonding process to significantly…

  • Reversed-Phase MEB4 Columns

    Separation Methods Technologies

    SMT manufactures columns with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation substrate…

  • OL Series Reversed-Phase C8 Columns

    Separation Methods Technologies

    OL Series SMT SAM-C8 phase with the lowest functional ligand coverage confirmed with carbon analysis results of 6% carbon load. In these series, the proportional ratio of the functional ligand, octyl or C8 molecule , mixed with the proprietary spacer molecule, is reduced. The result is a…

  • Reversed-Phase Phenyl-Hexyl Columns

    Separation Methods Technologies

    SMT Phenyl-Hexyl column or PhenH column, like the other SMT Phenyl columns, provides unique selectivity for aro- matic compounds when compared to other reversed-phase packings such as C18 and C8. The ìÛ-electrons of the phe- nyl group can interact with the aromatic ring of an analyte…

  • OD Series Reversed-Phase C18 Column

    Separation Methods Technologies

    OD Series: SMT SAM-C18 phase with the highest functional ligand coverage confirmed with carbon analysis results of 24% carbon load. In these series, a very high density of the functional ligand, octadecyl (C18) molecule, is achieved through meticulous mixture of the C18 with proprietary spacer…

  • Bulk MetalSep

    Separation Methods Technologies

    SMT MetalSep is offered as bulk packing materials for low pressure liquid chromatography, solid phase extraction, preparatory and process scale applications. The packings consist of proprietary strong cation exchange functional ligands that are chemically attached on silica substrate using SAM…

  • Reversed-Phase MEB2 Columns

    Separation Methods Technologies

    SMT manufactures columns with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation substrate…

  • O Series Reversed-Phase C8 Columns

    Separation Methods Technologies

    O Series SMT SAM-C8 phase with the highest functional ligand coverage confirmed with carbon analysis results of 12% carbon load. In these series, a very high density of the functional ligand, octyl molecule or C8, is achieved through meticulous mixture of the C8 with proprietary spacer…

  • ODL Series Reversed-Phase C18 Columns

    Separation Methods Technologies

    ODL Series: SMT SAM-C18 phase with the lowest functional ligand coverage confirmed with carbon analysis results of 12% carbon load. In these series, the proportional ratio of the functional C18 molecule, mixed with the proprietary spacer molecule, is reduced. The result is a packing material with…

  • Normal Phase Aminopropyl Columns

    Separation Methods Technologies

    SMT manufactures very stable aminopropyl [NH2] columns. SMT aminopropyl columns are often recommended for the separation of polar compounds and can be used in three separation modes: Normal Weak Anion Exchange Reversed-Phase In normal phase mode, the columns can be used to…

  • Bulk Silica

    Separation Methods Technologies

    SMT manufactures the most reliable silica based packing materials available in the market today. When silica is used as the stationary phase, the functional groups involved in separation are the surface silanols. However, metal impurities in silica may provide additional sites of interaction for…

  • Reversed-Phase C6 Columns

    Separation Methods Technologies

    SMT SAM-C6 columns consist of Hexyl as the functional ligand. The columns offer selectivities that are different from C8 and C18 reversed-phase columns when applied to separation of polyaromatic hydrocarbons. SMT-C6 columns are specially designed as complementary alternatives for the separation…

  • Reversed-Phase C3 Columns

    Separation Methods Technologies

    SMT SAM-C3 columns consist of Propyl as the functional ligand. The columns offer selectivities that are different from C8 and C18 reversed-phase columns when applied to separation of polyaromatic hydrocarbons. SMT-C3 columns are specially designed as complementary alternatives for the separation…

  • Reversed-Phase MEB1 Columns

    Separation Methods Technologies

    SMT manufactures columns with short carbon chains for rapid analysis of basic, neutral, and mildly acidic drugs and small molecules. These columns provide excellent baseline resolution for small basic molecules including therapeutic drugs. The bonding scheme ensures proper deactivation substrate…

  • Normal Phase Diol 1 Columns

    Separation Methods Technologies

    SMT-Diol columns are developed as an alternative for silica columns used in normal phase separation methods. The Diol [-OH] functional group is controlled, and as such, provides more reproducible separation when compared to separation on silanols [-OH] from bare silica surface. Furthermore, the…

  • Specialty C12 Columns

    Separation Methods Technologies

    SMT-C12 columns consist of Dodecyl as the functional ligand. The columns offer selectivities that are slightly different from C8 and C18 reversed-phase columns when applied to separation of polyaromatic hydrocarbons. SMT-C12 columns are specially designed as complementary alternatives for the…

  • Bulk C8

    Separation Methods Technologies

    SMT manufactures the most reliable silica based octyl (C8) column available in the market today. This advanced new column is very stable at a wide pH range and high temperatures. SMT utilizes a proprietary bonding scheme that allows the resulting bonded phases to perform separation of basic,…

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