Sulfanilamide is a molecule containing the sulfonamide functional group attached to an aniline. As a sulfonamide antibiotic, it functions by competitively inhibiting (i.e., by acting as a substrate analogue) enzymatic reactions involving para-aminobenzoic acid (PABA). PABA is needed in enzymatic reactions that produce folic acid which acts as a coenzyme in the synthesis of purine, pyrimidine and other amino acids.
Sulfanilamide is used used as Antibacterial agent. It is also used to treat Vaginal infection caused by fungus.
Sulfonamide antibiotic blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Mode of Action: A competitive inhibitor of dihydropteroate synthestase to block the synthesis of folic acid. Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia. Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Key Applications: Antibiotic
Product Type: Biochemicals
Biochemical Category: Pharmaceuticals
Density: 1.08 g/mL(Lit.)
Melting Point: 160 - 170°C
Partition Coefficient: log Kow = -0.62(Lit.)
UV/Visible Absorbance: λ max (water)-255 - 259 nm
Presentation: White Powder
Format: Powder
pKa: pKa = 10.43, pKb = 11.63(Lit.)
Solubility: Soluble in 1g dissolves in 37mL alcohol, 5mL acetone; glycerol, ether, benzene, petroleum ether.
Storage & Handling: Store at Room Temperature(15-30°C)