Chloroquine is an aminoquinoline antimalarial that is clinically used to treat malaria. Chloroquine’s anti-parasitic activity stems from its ability to bind heme, resulting in disruption of membrane function and cell lysis. Chloroquine also displays antiviral, immunosuppressive, and anticancer…

Acepromazine is a phenothiazine derivative antipsychotic agent related to chlorpromazine. Acepromazine maleate is primarily used in veterinary field as a sedative and antiemetic, although it has previously been used as an antipsychotic in humans. Acepromazine acts as an antagonist at D1/2 and…

Aprepitant is an inhibitor of the tachykinin/neurokinin 1 (NK1) receptor that acts as an antiemetic or anti-nausea medicine. Aprepitant also exhibits some anticancer chemotherapeutic and anti-angiogenic benefit through its inhibition of NK1 receptors, preventing binding of substance P and…

Ciprofloxacin is a second generation fluoroquinolone antibiotic that exhibits antibacterial activity against both gram negative and gram positive bacteria. Ciprofloxacin inhibits DNA gyrase and topoisomerase IV, preventing DNA replication.

Berteroin is a Erucin homolog that may exhibit antioxidative and anti-androgenic activities. Berteroin is an isothiocyanate (ITC) compound that decreases androgen receptor levels in prostate cancer cells. Berteroin also displays anti-inflammatory properties, decreasing LPS-induced release of…

AMG-458 is an inhibitor of c-MET that exhibits anticancer chemotherapeutic activity. AMG-458 enhances the radiosensitivity of lung adenocarcinoma cells, decreasing activation of Akt and ERK and inducing apoptosis. In vivo, this compound inhibits the growth of glioblastoma tumors.

Capsanthin is a carotenoid originally found in Capsicum that exhibits anticancer and chemopreventive activities. In leukemia cells, capsanthin upregulates expression of PPAR?, Nrf2, and p21, downregulates expression of cyclin D1, induces apoptosis, and inhibits cellular proliferation. In animal…

D,L-Aminogluthethimide is an inhibitor of aromatase and adrenal steroid synthesis that exhibits immunosuppressive and anticancer chemotherapeutic activities. This compound is used to treat breast cancer and Cushing’s disease.

AS-703026 is an inhibitor of MEK1/2 that exhibits anticancer chemotherapeutic activity. In vitro, AS-703026 inhibits proliferation of melanoma cells. In both in vitro and in vivo models of colorectal cancer containing WT Ras or mutant KRAS, AS-703026 inhibits growth of cells and also of tumors.…

4-Aminosalicylic acid exhibits anti-inflammatory, antioxidative, and antibacterial activities; it is clinically used to treat inflammatory bowel disease (IBD), Crohn’s disease, and colitis, as it acts primarily in the colon. 4-Aminosalicylic acid is used against Mycobacterium as a treatment for…

Carboplatin is a platinum-based cross-linking agent that exhibits immunomodulatory and anticancer chemotherapeutic activities. Carboplatin binds DNA with slower kinetics than other platinum drugs, inhibiting DNA transcription and replication; it is clinically used to treat various cancers.…

Cembrenediols are diterpenes originally found in Anisomeles. These compounds exhibit antibacterial activity against Mycobacterium and antifungal activity against Colletotrichum. Grade: ≥98%

CEP-32496 is a kinase inhibitor that has multikinase binding activity but remains selectively cytotoxic for mutant (V600E) B-Raf (versus WT); it exhibits anticancer chemotherapeutic activity. Also contributing to the ability of CEP-32496 to inhibit cell proliferation, this compound inhibits pMEK…

Butylated hydroxyanisole (BHA) exhibits antioxidative and anticancer activities. BHA is commercially used as a food additive or preservative, as its free radical scavenging ability stabilizes free radicals and prevents food spoilage. BHS also increases activity of superoxide dismutase (SOD) in…

Chloramphenicol is an antibiotic compound that binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Chloramphenicol exhibits antibacterial activity against Streptomyces.

Amlexanox is an azoxanthone derivative that is used to treat recurring aphthous ulcer and asthma. Amlexanox alters cytoskeleton function and inhibits cell migration and proliferation through binding to S100A12 and S100A13 proteins and attenuation of actin stress fiber formation and FGF1 release.…

Acipimox is a niacin derivative that acts as an anti-hyperlipidemic. Acipimox decreases levels of triglycerides, LDL, and free fatty acids, and increases levels of HDL. Acipimox decreases cAMP levels and AMPK activity, suppressing lipolysis by lipase. Grade: ≥98%

Bis(aziridinyl)methylaminophosphine is an anti-fertility/sterilization agent used to sterilize male insects and lamprey eels. This compound induces DNA fragmentation in spermatozoa and is very hazardous.

AVL-292 is a Bruton’s tyrosine kinase (BTK) inhibitor that exhibits anticancer chemotherapeutic activities. AVL-292 is in clinical development as a potential treatment for B-cell-related disorders such as chronic lymphocytic leukemia (CLL).

N-Acetyl-L-cysteine exhibits antioxidative, mucolytic, anti-inflammatory, antiviral, antipsychotic, and neuromodulatory activities. N-Acetyl-L-cysteine has clinically been used to treat acetaminophen overdose; it is occasionally commercially sold as a supplement. N-Acetyl-L-cysteine acts as a…

Carfilzomib is an analog of epoxomicin that functions as a proteasome inhibitor. This drug has been approved for use in humans with multiple myeloma. Carfilzomib binds irreversibly to the 20S proteasome, which exhibits chymotrypsin-like activity and is responsible for degradation of cellular…

Ambroxol is a bronchial expectorant that also exhibits antioxidative activity. Ambroxol stimulates the ciliary beat frequency and increases mucous secretion in the lung and trachea. In clinical settings, ambroxol increases levels of thioredoxin and thioredoxin reductase, decreasing oxidative stress…

Alfuzosin is an a1-adrenergic receptor antagonist that is used clinically to treat benign prostatic hyperplasia (BPH); it relaxes prostatic smooth muscle and increases the urinary flow rate. Alfuzosin also delays cardiac repolarization by increasing the Na+ current. This compound prolongs action…

Ceftazidime is a third generation β-lactam cephalosporin antibiotic. Ceftazidime exhibits antibacterial efficacy against most gram positive and some gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Grade: ≥97%

L-(+)-Alliin is a cysteine derivative originally found in Allium sativum (garlic); it exhibits anti-inflammatory, neuromodulatory, anti-diabetic, anti-hyperlipidemic, antioxidative, cardioprotective, and anti-angiogenic activities; it is the optically active and orally bioavailable isomer of…