Bottle, Glass, Clear, 1 mg, Cayman Chemical

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  • Cayman Chemical

    An internal standard for the quantification of oleoyl serotonin by GC- or LC-MS.

  • Cayman Chemical

    A mycotoxin produced from F. moniliforme that functions as an inhibitor of ceramide synthase (sphingosine N-acyltransferase).

  • Cayman Chemical

    A potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM); does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases; blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and…

  • A LPA analog containing stearyl alcohol at the sn-1 position; exhibits platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.

  • A natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes; also a weak inhibitor of the related zinc metalloprotease ECE (Ki = 3.5 µM); has little or no effect on a variety of other proteases.

  • Cayman Chemical

    Iloprost is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the human recombinant IP and EP1 receptors with a Ki of 11 nM. Iloprost…

  • Cayman Chemical

    A selective inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2; rapidly passes the blood-brain barrier and has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior.

  • Cayman Chemical

    A stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle; stimulates PHD activity and increases HIF-1α turnover when used at 1 mM; competitively blocks succinate- or fumarate-mediated inhibition of PHD.

  • Cayman Chemical

    PGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically…

  • Cayman Chemical

    A selective inhibitor of TAF1 bromodomain 2 (Kd = 1.8 µM; IC50 = 0.9 µM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.

  • Cayman Chemical

    A specific and potent inhibitor of MPC carrier activity; potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50 = 50 nM).

  • Cayman Chemical

    An Hsp90 inhibitor with an IC50 value of 47 nM; induces the expression of HSP27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.

  • 13,14-dihydro-15-keto PGF1α is a metabolite of PGF1α that has been reported in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α.

  • Cayman Chemical

    An ethyl ester prodrug of the JMJD3 selective histone demethylase inhibitor GSK-J1; reduces LPS-induced proinflammatory cytokine production, including that of TNFα (IC50 = 9 µM) in human primary macrophages.

  • An inhibitor of S1P lyase; treatment of mice (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs, resulting in reversible lymphopenia.

  • Cayman Chemical

    A lipid peroxidation product; actively modifies histidine and lysine residues on proteins and causes protein cross-linking.

  • Unnatural C-15 epimer of Travoprost.

  • Cayman Chemical

    A metabolite of thyroid hormone.

  • Cayman Chemical

    A triazolothiadiazine that inhibits PDE4 (EC50 = 18.7 nM in a cell-based assay); selectively inhibits PDE4A (IC50 = 6.7 nM) over PDE4B1, PDE4B2, PDE4C1, and PDE4D2 (IC50 = 48.2, 37.2, 452, and 49.2 nM, respectively).

  • Cayman Chemical

    A major phase I metabolite of the mycotoxin α-zearalanol (zeranol), a non-steroidal estrogen produced by fungi; an estrogen receptor agonist (EC50 = 0.11 µM).

  • Cayman Chemical

    A secondary metabolite produced by fungi; inhibits IgE production by mouse B cells in culture (IC50 = 3.6 μM) and dose-dependently (0.4-25 μg/ml) stimulates neuritogenic activity in rat pheochromocytoma PC12 cells; demonstrates nematicidal activity at 300 μg/ml.

  • Cayman Chemical

    A inhibitor of Epac1 and Epac2 (IC50s = 3.2 and 1.4 µM, respectively); blocks Akt phosphorylation and insulin secretion in pancreatic β cells and inhibits the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.

  • Cayman Chemical

    A bioactive lignan component of P. amarus with antioxidative and hepatoprotective properties; scavenges DPPH radicals (IC50 = 7.4 µM) and alleviates carbon tetrachloride-induced lipid peroxidation and cytotoxicity in a human hepatoma HepG2 cell line.

  • Cayman Chemical

    A potent inhibitor of PORCN (IC50 = 74 pM), completely blocking Wnt secretion into culture media; prevents activation of all evaluated Wnt family members; effective in vivo as well as in vitro; blocks the progression of breast cancer while downregulating Wnt/β-catenin pathway target…

  • Cayman Chemical

    A β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity; often used to examine the activity of the drug-transporting MDR1 gene product P-glycoprotein.

  • Cayman Chemical

    An aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM) without effect on SIRT1 or SIRT3-6; increases α-tubulin acetylation in HeLa cells.

  • Cayman Chemical

    A RARβ agonist, RARα/γ antagonist that inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1 arrest; used to trigger the differentiation of mouse embryonic stem cells.

  • Cayman Chemical

    An inhibitor NF-κB activation in vitro and in vivo (IC50 = 5 µM).

  • Cayman Chemical

    An analog of ceramide that inhibits alkaline ceramidase (IC50 ~5 µM); suppresses growth of HL-60 cancer cells in culture.

  • Cayman Chemical

    C-6 NBD ceramide is a biologically active fluorescent analog of short chain, membrane-permeable ceramides. It is as effective as C-6 ceramide in the inhibition of viral glycoprotein transport through the Golgi. C-6 NBD ceramide has been used as a fluorescent substrate for the activity of…

  • Cayman Chemical

    A non-selective bromodomain inhibitor that at 1 µM has been shown to accelerate FRAP recovery of BRD4 and CREBBP bromodomains in HeLa cells.

  • Cayman Chemical

    A dual inhibitor of IGF1R kinase and IR (IC50s = 100 and 73 nM, respectively); blocks IFG1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in ML-1 cells; reverses EMT in MCF10A cells overexpressing constitutively activated IGF1R.

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