The L isomer of the biologically important D-myo-inositol-1,4,5-triphosphate; does not evoke a rise in intracellular calcium when added to cells.

A potent inhibitor of LSD1 (IC₅₀ = 0.02 µM) that less effectively inhibits MAO-A and MAO-B (IC₅₀s = 1.38 and 0.72 µM); blocks the expression of IE genes of HSV and hCMV in mammalian cells; represses HSV primary infection in mice and blocks HSV reactivation from…

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor beta (NR1H2), a ligand-dependent transcription factor commonly referred to as LXRβ. INDIGO’s reporter cells include the…

A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC₅₀s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC₅₀ = 870 ng/ml); enhances the anti-fungal activity of rapamycin.

An activated fluorescent molecule (excitation: 494 nm, emission: 519 nm) used for labeling proteins; reacts optimally with sulfhydryl groups on cysteine side chains at pH 7, forming a stable thioether bond.

An analog of geldanamycin which has potent in vivo activity and reduced toxicity; has diverse anti-tumor actions; promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).

A synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 vs. 17 nM, respectively); has anti-inflammatory effects.

A small molecule inhibitor of tankyrase 1 and 2 (IC₅₀ = 11 and 4 nM, respectively); increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin; inhibits colony formation of APC-deficient colorectal cancer cells at 0.33 µM.

A chromogenic substrate that, like other tetrazolium compounds, can be reduced to produce a colored formazan derivative; used in the “NBT test” to evaluate the activity of NADPH oxidase in phagocytes; paired with PCIB for the colorimetric detection of alkaline phosphatase activity.

A bioactive sterol that can affect cholesterol homeostasis, membrane properties and cell survival; inhibits CYP7A1 with an IC₅₀ = ~ 1 µM; can be used as a standard in the determination of cholesterol derivatives by GC-MS or HPLC.

Concentration: 2% w/v Composition: Water 98.01%, Formic Acid 1.99% Boiling Point: 100°C Density: 1 Melting Point: 0.0°C Color: Colorless liquid Physical State: Liquid pH Range: 2 Solubility Information: Miscible Shelf Life: 24 Months Storage: Ambient DOT: NOT REGULATED.

The reduced form of the electron acceptor NADP+ and acts as an electron donor in various biological reactions.

A phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions.

A selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC₅₀ = 1.5 μM); blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.

An internal standard for the quantification of CAY10429 by GC- or LC-MS.

A reversible, selective, allosteric antagonist of mGluR7 that blocks agonist-induced calcium mobilization (IC₅₀ = 26 nM).

4-(hydroxymercuri)Benzoic Acid(PHMB) is used to inhibit cysteine-protease and acts as a reversible thiol-specific blocker. While blocking the acylated ghrelin degradation, it allows the AcetylCholine Esterase AChE™ used in SPI-Bio EIA kits to work normally, in contrast to serine-protease inhibitors.

An inhibitor of PDKs, resulting in an increase in PDH activity (EC₅₀ = 5.2 nM for PDK2); less potently inhibits PDK1 and PDK3 (IC₅₀s = 87 and 600 nM, respectively).

A polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.

Composition: Ethyl Alcohol 83.30%, Water 4.62%, Isopropyl Alcohol 4.60%, Methyl Alcohol 4.16%, Hydrochloric Acid 2.51%, Picric Acid 0.81% Density: 0.83 Color: Yellow liquid Physical State: Liquid pH Range: Neutral Solubility Information: Miscible Shelf Life: 12 Months Storage: Ambient…

A potent inhibitor of autotaxin (IC50 = 2.8 nM in an in vitro enzyme assay); at 30 mg/kg, reduces LPA production by >95% following carrageenan-induced inflammation in rats and inhibits autotaxin activity in human whole blood (IC50 = 101 nM).

A substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication; participates in G-protein-related signal transduction where it is converted to GDP through the action of GTPases.

A synthetic phosopholipid that can be used for liposome production in order to study the properties of lipid bilayers.

A precursor to Vitamin K2 that is capable of both redox cycling and arylating nucleophilic substrates by Michael addition; used as an antihemorrhagic agent and to inhibit the proliferation of various cancer cells.

A reversible inhibitor of the cis-Golgi ArfGEF, GBF1 (IC₅₀ = 3.3 µM); induces rapid dissociation of COPI vesicle coat protein from Golgi membranes and disassembly of the Golgi and trans-Golgi network, preventing bidirectional transport of endocytic cargo.

A SMO agonist that can promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 µM); used to characterize a novel SMO active site since it does not recognize the classic cyclopamine binding site utilized by other SMO agonists.

An endocannabinoid analog that does not bind to CB1, CB2, or TRPV1; at 5 mg/kg antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model; relaxes isolated rat mesenteric arteries and abdominal aorta, and increases the…

A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC₅₀ = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC₅₀s range from 1-7 μM).

An analog of SB203580, the highly specific pyridinylimidazole inhibitor of p38 MAPK; inhibits IL-1 production in the human monocytic cell line THP (IC50 = 0.20 µM) and binds CSAID binding protein, a serine/threonine kinase homologous to p38, inhibiting its kinase activity (IC50 = 0.03 µM).

DGLA is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Ethyl DGLA is an esterified version of the free acid which is less water soluble, but more ammenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as…

A potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM) and the common activating mutants of p100α (E542K, E545K, and H1047R) found in cancer; prevents proliferation in BT474 tumor xenografts and reduces MAPK signaling with twice daily dosing at 25 mg/kg.

An inhibitor of Cdc7 kinase (IC₅₀ = 10 nM) as well as Cdk9, (IC₅₀ = 34 nM); induces apoptotic cell death in multiple cancer cell types at 10 µM.