Bottle, Glass, Clear
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SBFI AM
Cayman ChemicalA membrane-permeant, fluorescent Na+ indicator dye; increasing concentration of Na+ increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm.
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Phomopsin A
Cayman ChemicalA cyclic hexapeptide mycotoxin that binds β-tubulin in a vinca domain; blocks microtubule growth, modulates the dynamics of microtubules, and interferes with mitosis.
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Abiraterone
Cayman ChemicalBlocks CYP17A1 by potently inhibiting both the 17α-hydroxylase and the 17,20 lyase activities (IC50 = 18 and 17 nM, respectively); essentially eliminates plasma testosterone while producing a 3- to 4-fold increase in plasma luteinizing hormone.
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(R,S)-AMPA
Cayman ChemicalThe defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission; contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.
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Zoniporide (hydrochloride)
Cayman ChemicalSelectively inhibits human NHE-1 with an IC50 value of 14 nM; reduces infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.
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10-Nitrolinoleate
Cayman ChemicalThe product of nitration of linoleate by NO-derived reactive species; activates PPARγ (Ki = 133 nM), inducing CD36 expression in macrophages, adipocyte differentiation, and glucose uptake; can also be metabolized to produce nitrite derivatives which in turn form NO, leading to increased cGMP production.
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Calcium Chloride, 58% (w/w), Volumetric
Reagents®Concentration: 58% w/w Composition: Calcium Chloride Dihydrate 58.12%, Water 41.44%, Hydrochloric Acid 0.44% Density: 1.41 Color: Colorless liquid Physical State: Liquid pH Range: Solubility Information: Miscible Shelf Life: 24 Months Storage: Ambient DOT: NOT REGULATED.
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Coelenterazine h
Cayman ChemicalA synthetic derivative of native coelenterazine that exhibits 16-fold higher luminescence intensity (emission maximum ~466 nm; half-total time of 0.6-1.2 sec) than native coelenterazine.
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Fenofibrate
Cayman ChemicalA PPARα agonist and hypolipidemic drug used clinically to treat dyslipidemia and cardiovascular disease; exhibits EC50 values of 18 and 30 µM for mouse and human PPARα, respectively.
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Fludarabine
Cayman ChemicalA nuclesoside analog that disrupts DNA synthesis in blood cells; effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.
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N-phenylacetyl-L-Homoserine lactone
Cayman ChemicalA small diffusible signaling molecule involved in quorum sensing in the model symbiont V. fischeri and the pathogens A. tumefaciens and P. aeruginosa.
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SCR7 pyrazine
Cayman ChemicalA small molecule inhibitor of DNA ligase IV that prevents nonhomologous end-joining by interfering with the ligase binding and activating apoptosis; inhibits cancer cell growth in vitro (IC50s = 8-120 µM) and in mouse models when co-administered with double-strand break-inducing…
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GDC-0941
Cayman ChemicalA potent pan inhibitor of class I catalytic subunits of PI3K, inhibiting p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM, respectively; inhibits the growth of certain types of cancer cells, and blocks signaling through PI3K to Akt, both in cells and in vivo.
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ß-acetyl-Boswellic Acid
Cayman ChemicalA non-reducing inhibitor of 5-LO that shows selectivity for 5-LO over 12-LO or COX; inhibits topoisomerase II activity and arrests cell cycling or induces apoptosis in cancer cells.
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Autocamtide-2-related Inhibitory Peptide
Cayman ChemicalA selective CaMKII inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
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Nodularin
Cayman ChemicalA hepatotoxic monocylic pentapeptide that acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively.
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Microcystin-RR
Cayman ChemicalA toxin produced by cyanobacteria that inhibits the catalytic activity of protein phosphatases PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.
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Formic Acid, 2% (w/v), Standardized
Reagents®Concentration: 2% w/v Composition: Water 98.01%, Formic Acid 1.99% Boiling Point: 100°C Density: 1 Melting Point: 0.0°C Color: Colorless liquid Physical State: Liquid pH Range: 2 Solubility Information: Miscible Shelf Life: 24 Months Storage: Ambient DOT: NOT REGULATED.
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17-phenyl trinor Prostaglandin F2a diethyl amide
Cayman ChemicalAn F-series PG analog in which the C-1 carboxyl group has been modified to an N-diethyl amide; dialkyl amides such as a 17-p-PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids.
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2-Acetyl-5-tetrahydroxybutyl Imidazole
Cayman ChemicalAn inhibitor of S1P lyase; treatment of mice (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs, resulting in reversible lymphopenia.
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BMS 303141
Cayman ChemicalA cell-permeable ACL inhibitor (IC50 = 0.13 µM) that has been reported to reduce weight gain and lower plasma cholesterol, triglycerides, and glucose in a mouse model of hyperlipidemia.
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Hygromycin B
Cayman ChemicalAn antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.
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Piroxicam
Cayman ChemicalAn NSAID that non-selectively and reversibly inhibits both COX isoforms (IC50 = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).
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Cholic Acid 7-sulfate
Cayman ChemicalA naturally occurring metabolite of bile acid that is produced by the conjugation of cholic acid and sulfate, predominantly in the liver and gut.
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Bilirubin
Cayman ChemicalA yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase; has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions.
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D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)
Cayman ChemicalLargely acts a cell signaling intermediate; serving as substrate to produce IP5s, which can be further phosphorylated to produce Ins(1,2,3,4,5,6-)P6; also phosphorylated to produce phytic acid, which serves diverse roles in eukaryotic tissues; a poor activator of the Ins(1,4,5)-P3 receptor in vitro.
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a-Amanitin
Cayman ChemicalA mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml), preventing translocation of the enzymes on DNA; used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.
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Golgicide A
Cayman ChemicalA reversible inhibitor of the cis-Golgi ArfGEF, GBF1 (IC50 = 3.3 µM); induces rapid dissociation of COPI vesicle coat protein from Golgi membranes and disassembly of the Golgi and trans-Golgi network, preventing bidirectional transport of endocytic cargo.
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22(R)-hydroxy Cholesterol
Cayman ChemicalAn endogenous agonist for LXRα (EC50 = 325 nM) that can induce the expression of the ABCA1 reverse cholesterol transporter to inhibit the overall absorption of cholesterol; used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists.
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SW033291
Cayman ChemicalA potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo; rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection.
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FH535
Cayman ChemicalAn inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ; blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ; selectively toxic to some carcinoma cell lines expressing the…
