Synonyms: tert-Butyl 4-(4-methyl-1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate; SHI-16 Molecular Formula: C15H24N4O3 Molecular Weight: 308.38 Linear Structural Formula: C15H24N4O3 Application: Serine Hydrolase inhibitors are small molecule fragments that react in vitro with…

Synonyms: 6-Amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide; 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-Pyridinecarboxamide; N-Methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide; PF 01247324; PF-1247324 Molecular Formula: C13H10Cl3N3O Molecular Weight: …

Synonyms: tert-Butyl 4-((4-(trifluoromethyl)phenyl)carbamoyl)-1,4-diazepane-1-carboxylate; SHI-5 Molecular Formula: C18H24F3N3O3 Molecular Weight: 387.4 Linear Structural Formula: C18H24F3N3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro…

Synonyms: tert-Butyl 4-(pyridin-2-ylcarbamoyl)piperazine-1-carboxylate; SHI-1 Molecular Formula: C15H22N4O3 Molecular Weight: 306.36 Linear Structural Formula: C15H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

An indole diterpene which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM).

PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT. Synonyms: …

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG. Molecular Formula: C18H25NO6 Molecular…

Synonyms: 5-(4-Chloro-phenyl)-[3,3']bipyridinyl-6,6'-diamine dihydrochloride Molecular Formula: C16H13ClN4 · 2HCl Molecular Weight: 369.68 Linear Structural Formula: C16H13ClN4 · 2HCl Purity: >=98% (HPLC) Storage: room temp Biochem Physiol Actions: PF-06260933…

An intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3; plasma or serum levels are commonly used as an indicator of an individual’s vitamin D status.

Synonym(s): 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone; 1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone Empirical Formula: C₁₂H₇Cl₂NO₃S₂ Linear Formula: …

A macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis; induces mitotic arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate,…

A colchicine derivative that inhibits tubulin polymerization (IC₅₀ = 2.1 μM) with low toxicity; suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase; used to synchronize cells and for karyotyping in cytogenetic studies.

Synonyms: tert-Butyl(2-(N,4-dimethyl-1H-pyrazole-1-carboxamido)ethyl)(methyl)carbamate; SHI-19 Molecular Formula: C14H24N4O3 Molecular Weight: 296.37 Linear Structural Formula: C14H24N4O3 Application: Serine Hydrolase inhibitors are small molecule fragments that react in vitro with…

A selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 (IC₅₀ = 22 nM).

Synonyms: tert-Butyl methyl(2-(N-methyl-1H-pyrazole-1-carboxamido)ethyl)carbamate; SHI-20 Molecular Formula: C13H22N4O3 Molecular Weight: 282.34 Linear Structural Formula: C13H22N4O3 Purity: >=95% Application: Serine hydrolase inhibitors are small molecule fragments that react…

A potent, selective antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC₅₀ values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively; effective in vivo, as it resolves pulmonary edema resulting from myocardial…

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 µg in humans, given 1 to 3…

A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC₅₀ = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC₅₀s range from 1-7 μM).

Synonyms: tert-Butyl 4-((2-fluorophenyl)carbamoyl)piperazine-1-carboxylate; SHI-7 Molecular Formula: C16H22FN3O3 Molecular Weight: 323.36 Linear Structural Formula: C16H22FN3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

Synonyms: tert-Butyl methyl(2-(1-methyl-3-(4-(trifluoromethyl)phenyl)ureido)ethyl)carbamate; SHI-6 Molecular Formula: C17H24F3N3O3 Molecular Weight: 375.39 Linear Structural Formula: C17H24F3N3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in…

An analog of wortmannin; irreversibly binds PI3K; inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap cells (IC₅₀ = 1.46 μM).

An intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates; subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.

A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases: p56lck (IC₅₀ = 4 nM), p59fynT (IC₅₀ = 5 nM), Hck (IC₅₀ = 5 nM).

Synonym(s): Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 Formula: C43H66N12O12S2 Formula weight: 1007.19 Purity: 96% CAS Number: 50-56-6 UN Number: UN2811 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2937.19 Hazard Statements: H300-H361 Fatal if swallowed.…

Synonyms: 2-Isopropoxy-d7-phenyl N-methylcarbamate; Propoxur-d7 Molecular Formula: C11D7H8NO3 Molecular Weight: 216.28 Linear Structural Formula: C11D7H8NO3 Purity: >=98.0% (HPLC) Storage: 2-8C Legal Information: PESTANAL is a registered trademark of Sigma-Aldrich…

Synonyms: 1'-Butyl-4'-piperidinylmethyl ester; 8-Amino-7-chloro-2,3-dihydro-1,4-benzodioxan-5-carboxylic acid; N-1-Butyl-4-piperinylmethyl)-3,4-dihydro-2H-[1,3] oxazino[3,2-a]indole-10-carboxamide; Piboserod Molecular Formula: C22H31N3O2 Molecular Weight: 369.5 Linear Structural…

Synonyms: 2-Phenyl-3-(4-hydroxyphenyl)-5,7-bis(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine; 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]-pyrimidin-3-yl]phenol Molecular Formula: C20H11F6N3O Molecular Weight: 423.31 Linear Structural Formula: C20H11F6N3O MDL Number: …

Synonyms: alpha,alpha-Dimethylphenethylamine hydrochloride; alpha-Benzylisopropylamine hydrochloride; 1,1-Dimethyl-2-phenylethylamine hydrochloride; 2-Methyl-1-phenylpropan-2-amine hydrochloride; 2-Phenyl-tert-butylamine hydrochloride; alpha,alpha-Dimethylphenethylamine hydrochloride Molecular…

Synonyms: 1,3-Dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one Molecular Formula: C24H26N6O3 Molecular Weight: 446.5 Linear Structural Formula: C24H26N6O3 MDL Number: MFCD28155091 Purity: >=98%…

Synonyms: tert-Butyl 4-(4-methyl-1H-pyrazole-1-carbonyl)piperazine-1-carboxylate; SHI-13 Molecular Formula: C14H22N4O3 Molecular Weight: 294.35 Linear Structural Formula: C14H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the…

An analog of 1,24-dihydroxy vitamin D3 which, when used in a 4 μg/g ointment, suppresses psoriasis; inhibits the growth of both normal and psoriatic human keratinocytes (IC50 ~ 10 nM) via the vitamin D receptor; suppresses the production of RANTES and IL-8 by human dermal fibroblasts.