Deoxyribonuclease from beef pancreas, DNase I, was first crystallized by Kunitz. It is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3'. The…

Goat Anti-Human IgG F(c) Antibody is suitable for immunoassays where specificity to the immunoglobulin Fc region is desired. Antibody has been tested by ELISA, western blot immunoblot, and immunohistochemistry. Optimal concentrations in immunoassays should be determined by the researcher.

A potent and selective inhibitor of PLD1, both in vitro (IC₅₀ = 46 nM) and in cells (IC₅₀ = 11 nM); also effective as a PLD2 inhibitor at higher concentrations (IC₅₀ = 933 nM in vitro; 1,800 nM in cells); strongly inhibits the invasive migration of several breast…

A purine derivative that reversibly antagonizes aryl hydrocarbon receptor signaling (IC₅₀ = 127 nM in CD34+ cells); induces a 50-fold increase in human embryonic stem cells expressing CD34 (EC₅₀ = 120 nM) and a 17-fold increase in stem cells that retain the ability to engraft…

A secondary metabolite produced by fungi; inhibits IgE production by mouse B cells in culture (IC₅₀ = 3.6 μM) and dose-dependently (0.4-25 μg/ml) stimulates neuritogenic activity in rat pheochromocytoma PC12 cells; demonstrates nematicidal activity at 300 μg/ml.

A natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).

A sulfated form of taurocholic acid that may be involved in the elimination and detoxification of bile acids during hepatobiliary diseases.

ApNA is one of several nitroaniline fatty acid amides which can be used to measure FAAH activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate AEA (Item No. 90050). It also will hydrolyze…

An antitumor antibiotic that crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis, to stimulate genetic recombination, chromosome breakage and sister chromatid exchange, and to induce DNA repair.

A CYP17 inhibitor (IC₅₀ = 300 nM) that competitively blocks synthetic androgen binding (EC₅₀ = 845 nM) and antagonizes the androgen receptor in transcriptional activation assays; inhibits the growth of castration-resistant prostate cancer cells (IC₅₀ = 2.9 µM).

Paraoxon-ethyl-d10 (diethyl-d10) is an isotope-labeled analog of organophosphate pesticide paraoxon, wherein the diethoxy protons are replaced by deuterium. Synonyms: O,O-Diethyl-d10 O-(4-nitrophenyl) phosphate; Diethyl-d10 p-nitrophenyl phosphate; Ethyl-d10 paraoxon Molecular Formula: …

A sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, blocking the activation of calmodulin-dependent phosphodiesterase with an IC₅₀ value of 9 μM.

An activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM); reduces hypertension, limits cardiomyocyte hypertrophy, protects against ischemia/reperfusion injury, and reduces morbidity and mortality in response to endotoxic shock.

A specific Akt inhibitor that has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells (IC₅₀ = 30-60 nM in vitro); inhibits Akt, PDK1, and FLT3 in acute myelogenous leukemia cells, decreasing the colony-forming ability of these cells (IC₅₀…

A broad-spectrum antibiotic that inhibits protein synthesis by inducing miscoding; commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells.

A selective, cell permeable inhibitor of CaMKII (IC₅₀ = 900 nM).

A cell-permeable green fluorescent dye (excitation and emission maxima are 494 and 520 nm, respectively); used to analyze cell proliferation and track cell migration in vivo.

Synonyms: 1,3-Dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one Molecular Formula: C24H26N6O3 Molecular Weight: 446.5 Linear Structural Formula: C24H26N6O3 MDL Number: MFCD28155091 Purity: >=98%…

A non-cholestatic regioisomer of E217G that acts as a substrate for MRP2, competing with E217G for MRP2-mediated transport (IC₅₀ = 14.2 µM).

A synthetic PGA1 analog with structural features similar to 15-deoxy-Δ12,14-PGJ2, a ligand for PPARγ.

A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively).

A glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase.

A synthetic heptapeptide that acts as a specific substrate for PKA.

A naturally-occurring amino acid which is a stable antioxidant; scavenges free radicals and oxidants, controls NF-κB activation, and inhibits inflammatory gene expression; blocks oxidative DNA damage and cell death.

Protease from Staphylococcus aureus strain V8 is composed of a single polypeptide chain. The Staphylococcus strain V8 protease specifically cleaves peptide bonds on the carboxyl (COOH) terminal side of aspartic and glutamic acid residues. Protease V8 is used for selective cleavage of proteins…

Synonyms: N -[(3 R )-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine Formula: C₂₀H₁₈ClNO₆ Formula Weight: 403.81 CAS No.: 303-47-9 Storage Temperature: −20°C

A selective dual inhibitor of mTORC1 and mTORC2.

Synonyms: (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one Molecular Formula: C23H21BrN2O2S Molecular Weight: 469.39 Linear Structural Formula: C23H21BrN2O2S Purity: >=98% (HPLC) Storage: 2-8C Biochem Physiol…

A phosphonic analog of ATP and agonist of P2X1 and P2X3 (EC50 = ~1 µM); ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors; used as a stable analog of ATP to study the interaction of ATP with kinases and other proteins.

An indole-based, time-dependent inhibitor of Icmt (IC₅₀ = i = 0.14 µM for the final complex); decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells.

Synonym(s): 6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Empirical Formula: C₁₈H₂₀NClO₂ -+ HBr Linear Formula: C₁₈H₂₀NClO₂ -+ HBr Formula Weight: 398.72 MDL Number: …

A natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina; a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.