A colchicine derivative that inhibits tubulin polymerization (IC₅₀ = 2.1 μM) with low toxicity; suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase; used to synchronize cells and for karyotyping in cytogenetic studies.

Synonym(s): Demecolcine, N-Methyl-N-desacetylcolchicine Formula: C21H25NO5 Formula weight: 371.43 Purity: 98+% CAS Number: 477-30-5 UN Number: UN2811 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2939.99 Hazard Statements: H300-H361 Fatal if swallowed.…

Demecolcine, also known as colcemid, is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. Demecolcine is an antineoplastic agent used to immobilize chromosomes by…