1 g, Bottle, Glass, Clear, Cayman Chemical
-
IPTG (dioxane free)
Cayman ChemicalInduces protein expression where the gene is under the control of the lac operator by triggering transcription of the lac operon in cloning procedures.
-
SAHA
Cayman ChemicalAn HDAC inhibitor of class I and class II HDACs at around 50 nM; arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.
-
Amlodipine
Cayman ChemicalA dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle; inhibits calcium-induced contractions in depolarized rat aorta (IC50 = 1.9 nM), displaying a slow rate of association and dissociation in isolated vascular and…
-
FTY720
Cayman ChemicalA structural analog of sphingosine and a novel immune modulator; inhibits lymphocyte emigration from lymphoid organs; becomes phosphorylated by sphingosine kinase in vivo to act as a potent agonist at S1P1, S1P3, S1P4, and S1P5.
-
Pyronin Y
Cayman ChemicalA fluorescent probe which stains dsRNA in living or fixed cells as well as in tissues; amenable to FC; maximum excitation is at 540-550 nm, with maximum emission at 560-580 nm.
-
-
NADP+ (sodium salt hydrate)
Cayman ChemicalThe oxidized form of NADPH; serves as a cofactor in various biological reactions.
-
Colistin (sulfate)
Cayman ChemicalA polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.
-
Hygromycin B
Cayman ChemicalAn antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.
-
Amphotericin B
Cayman ChemicalA polyene macrolide used in the treatment of infections caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures; binds with ergosterol in fungal cell membranes, altering membrane permeability and ultimately…
-
Amiodarone (hydrochloride)
Cayman ChemicalA class III antiarrhythmic agent; inhibits KCNH2 with an IC50 value of 1 µM; also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.
-
Fluconazole
Cayman ChemicalA triazole antifungal agent that is effective against most Candida strains.
-
Sodium 4-Phenylbutyrate
Cayman ChemicalA chemical chaperone that rescues the trafficking of misfolded proteins and weakly blocks HDAC activity (IC50 = 0.4 mM), leading to cell cycle arrest, differentiation, and/or apoptosis of various tumors.
-
L-Glutathione, reduced
Cayman ChemicalGSH is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of…
-
(±)-Jasmonic Acid
Cayman ChemicalA plant growth regulator involved in the signaling mechanisms for a variety of conditions including plant defense, wound healing, tuberization, fruit ripening, and senescence.
-
Sodium Hydrogen Sulfide (hydrate)
Cayman ChemicalAn H2S donor commonly used in cellular and whole animal experimental systems.
-
Indole-3-Acetic Acid (sodium salt)
Cayman ChemicalA naturally occurring plant hormone of the auxin class that stimulates cell elongation and division, promoting plant growth and development.
-
Clinafloxacin (hydrochloride)
Cayman ChemicalA fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).
-
Stigmasterol
Cayman ChemicalA natural plant sterol that can be isolated from certain seed oils and herbs, including those used for therapeutic purposes.
-
7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol
Cayman ChemicalA benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.
-
Carprofen
Cayman ChemicalAn NSAID commonly used in animals to combat pain and inflammation, particularly as associated with osteoarthritis; inhibits both COX-1 and COX-2 (IC50s = 22.3 and 3.9 µM, respectively) and also FAAH (IC50 = 74 µM).
-
D-Luciferin (potassium salt)
Cayman ChemicalA chemiluminescent substrate of firefly luciferase which produces light upon oxidative decarboxylation in the presence of ATP.
-
Spectinomycin (hydrochloride hydrate)
Cayman ChemicalAn aminocyclitol antibiotic active against Gram-negative and Gram-positive bacteria; inhibits protein synthesis by binding to the 30S ribosomal subunit and interfering with peptidyl tRNA translocation.
-
1,6-Anhydro-ß-D-mannopyranose
Cayman ChemicalA major organic tracer generated by burned cellulose; used to evaluate, in atmospheric samples, the burning of wood.
-
Naringenin
Cayman ChemicalA citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM); demonstrates antifibrotic, lipid lowering, and insulin-like properties.
-
L-Leucine 4-methoxy-ß-naphthylamide (hydrochloride)
Cayman ChemicalA cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities.
-
Tianeptine (sodium salt)
Cayman ChemicalAn atypical antidepressant with diverse actions, most notably on the glutamatergic system; attenuates glutamate release and modulates the function of AMPAR; acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641 nM for human and mouse receptors, respectively).
-
Lenalidomide
Cayman ChemicalAn analog of thalidomide that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines; induces proliferation and enhances the functional capacity of T-lymphocytes, amplifying co-stimulatory signaling pathways.
-
Lucigenin
Cayman ChemicalA dual purpose probe; a chemiluminescent probe that detects superoxide production by enzymatic and cellular sources; a fluorescent chloride-sensitive indicator, with fluorescence being quenched by chloride (excitation: 455 nm; emission: 505 nm).
-
5-Fluorocytosine
Cayman ChemicalAn antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil, a cytotoxic drug that inhibits viral infections and has cytotoxic effects on cancer cells.
-
Ceftazidime (hydrate)
Cayman ChemicalA broad-spectrum β-lactam antibiotic used for parenteral administration.
-
Ketoconazole
Cayman ChemicalAn orally active broad spectrum antifungal agent that blocks ergosterol biosynthesis by inhibiting the fungal CYP isoform CYP51; potently inhibits the mammalian analog CYP51A1 (IC50 = 63.5 nM), as well as a variety of other CYP isoforms.