1 g, Chemicals, Cayman Chemical
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(±)-Jasmonic Acid methyl ester
Cayman ChemicalA mixture of trans (3R/7R and 3S/7S) isomers; induces the synthesis of proteinase inhibitors in plant leaves; in cancer cells, suppresses proliferation and induces apoptosis; inhibits hexokinase that is bound to mitochondria; methyl jasmonate derivatives also have potential as anti-inflammatory agents.
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Amphotericin B
Cayman ChemicalA polyene macrolide used in the treatment of infections caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures; binds with ergosterol in fungal cell membranes, altering membrane permeability and ultimately…
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4-Pyrimidinecarboxaldehyde, dimethyl acetal
Cayman Chemical4-Pyrimidinecarboxaldehyde, dimethyl acetal is a synthetic intermediate useful for pharmaceutical synthesis.
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Vildagliptin
Cayman ChemicalAn inhibitor of DPP-4 (IC50 = 3.5-34 nM); also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or FAPα; blocks the degradation of several circulating peptides, including incretins; reduces fasting and postprandial glucose levels and decreases inflammatory…
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2-(hydroxymethyl)-Pyrimidine
Cayman Chemical2-(hydroxymethyl)-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.
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Colistin (sulfate)
Cayman ChemicalA polypeptide antibiotic effective against Gram-negative bacteria, including P. aeruginosa, A. baumannii, and K. pneumoniae.
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1,2-Dimyristoyl-sn-glycero-3-PC
Cayman ChemicalA synthetic phosopholipid that can be used for liposome production in order to study the properties of lipid bilayers.
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ß-D-Glucosamine Pentaacetate
Cayman ChemicalAn N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.
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Icariin
Cayman ChemicalAn inhibitor of human recombinant PDE5 (IC50 = 5.9 µM); used to treat erectile dysfunction and has been shown to have anti-cancer and antioxidant activity; induces differentiation of cardiomyocytes and increases the proliferation and differentiation of cultured human osteoblasts.
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Biotin-NHS
Cayman ChemicalA compound used to attach biotin to primary amines, such as lysines on the surface of proteins, under alkaline conditions (pH~8-9).
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Fisetin
Cayman ChemicalA natural flavonol and potent antioxidant with anti-inflammatory actions; activator of sirtuin 1, inhibitor of the spleen tyrosine kinase SYK, and suppressor of CD36 gene expression.
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Tianeptine (sodium salt)
Cayman ChemicalAn atypical antidepressant with diverse actions, most notably on the glutamatergic system; attenuates glutamate release and modulates the function of AMPAR; acts as an agonist of the µ-opioid receptor (EC50s = 194 and 641 nM for human and mouse receptors, respectively).
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Doxepin (hydrochloride)
Cayman ChemicalA tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.
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Bupivacaine
Cayman ChemicalAn amino-amide anesthetic that binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, preventing the generation of an action potential; inhibits the uptake of dopamine in striatal synaptosomes by 47% at 100 µM.
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3-Pyrimidin-2-yl-Propionic Acid
Cayman Chemical3-Pyrimidin-2-yl-Propionic Acid is a synthetic intermediate useful for pharmaceutical synthesis.
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Imiquimod
Cayman ChemicalAn imidazoquinoline compound that activates TLR7 (EC50 = 2.1 µM) on immune cells, inducing the production of IFN-α, IL-12, and other mediators; up-regulates the OGF receptor on cancer cells, blocking cell proliferation (IC50 = 2 µM).
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5-Fluorocytosine
Cayman ChemicalAn antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil, a cytotoxic drug that inhibits viral infections and has cytotoxic effects on cancer cells.
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L-Leucyl-L-Leucine methyl ester (hydrochloride)
Cayman ChemicalA lysosomal condensation product that selectively eliminates dipeptidyl peptidase I-expressing immune cells, including cytotoxic T cells and natural killer cells.
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Boldine
Cayman ChemicalAn aporphine alkaloid that possesses antioxidant and free-radical scavenging ability and has been linked to anti-inflammatory, anti-pyretic, anti-diabetic, anti-atherogenic, anti-platelet, anti-tumor, UV-protective, and hepatoprotective effects.
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Nifuroxazide
Cayman ChemicalA broad-spectrum nitrofuran antibiotic used against urinary tract infections and as therapy for acute diarrhea of bacterial origin; inhibits the survival and migration of cancer cells, suppressing tumor growth and metastasis in vivo, at least in part by inhibiting STAT3 (IC50 = 10 µM).
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Thymoquinone
Cayman ChemicalA natural phytochemical with anti-inflammatory effects; inhibits the growth of leukemia cells (IC50 = 1.5 μg/ml), inducing apoptosis; at 15 μM, suppresses STAT3-regulated gene expression and prevents angiogenesis.
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Stigmasterol
Cayman ChemicalA natural plant sterol that can be isolated from certain seed oils and herbs, including those used for therapeutic purposes.
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2'-Deoxyadenosine-5'-monophosphate
Cayman ChemicalA derivative of AMP that has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.
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Taurodeoxycholic Acid (sodium salt)
Cayman ChemicalA bile salt formed in the liver by conjugation of deoxycholate with taurine; used to solubilize lipids and membrane-bound proteins and also as a vehicle to assist with vaccine delivery.
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Amylose
Cayman ChemicalA polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.
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N-Octyl-ß-D-thioglucopyranoside
Cayman ChemicalA low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.
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n-Dodecyl-ß-D-maltoside
Cayman ChemicalA non-ionic detergent commonly used to solubilize membrane-associated proteins; helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation.
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Streptozotocin
Cayman ChemicalA glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA, leading to the destruction of beta cells.
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Levofloxacin
Cayman ChemicalA third generation fluoroquinolone with antibacterial activity; inhibits type II topoisomerases (IC50s = 8.06 and 9.81 µg/ml for DNA gyrase and topoisomerase IV, respectively).
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1,6-Anhydro-ß-D-mannopyranose
Cayman ChemicalA major organic tracer generated by burned cellulose; used to evaluate, in atmospheric samples, the burning of wood.
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Hygromycin B
Cayman ChemicalAn antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.
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Sodium 4-Phenylbutyrate
Cayman ChemicalA chemical chaperone that rescues the trafficking of misfolded proteins and weakly blocks HDAC activity (IC50 = 0.4 mM), leading to cell cycle arrest, differentiation, and/or apoptosis of various tumors.