An orally bioavailable, specific, broad spectrum JAK inhibitor (IC₅₀s = 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and JAK4, respectively); blocks cell-based JAK signaling induced by IL-2, IL-4, IL-6, IL-13, or IL-31 with IC₅₀ values ranging from 36 to 249 nM.

An intermediate in several metabolic pathways, including glycolysis and gluconeogenesis.

A FAHFA in which palmitic acid is esterified to 9-hydroxy palmitic acid.

A non-nucleoside DNA methyltransferase inhibitor (IC₅₀ = 115 nM in vitro) that significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity.

A plant hormone with diverse roles in disease resistance, plant development, and response to stresses; regulates gene expression and may contribute to epigenetic changes at the chromatin level.

DPI is an irreversible inhibitor of iNOS and eNOS with IC₅₀ values of 50 nM and 0.3 µM, respectively. This inhibition is potent, irreversible, and time and temperature dependent. NADPH, NADP+, and 2'5'-ADP block the inhibitory action of DPI. Similarly, FAD or FMN protect…

Synonym(s): 2-[(4-Azido-2-nitrophenyl)amino]ethanesulfonic acid monosodium salt dihydrate; N -(4-Azido-2-nitrophenyl) taurine sodium salt dihydrate; N -(4-Azido-2-nitrophenyl)-2-aminoethylsulfonic acid sodium salt dihydrate; NAP-Taurine sodium salt dihydrate Empirical Formula: …

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such as polyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1…

Synonyms: 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-; 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; 6-Gingerol CAS Number: 23513-14-6 Formula: C17H26O4 Formula Weight: 294.39 Linear Formula: C17H26O4 MDL No.: MFCD00210507 Purity: >=98% (HPLC) Storage: …

A cell permeable, competitive inhibitor of HIF-PH with effective concentrations in the low µM range.

A selective dual inhibitor of mTORC1 and mTORC2.

An indole diterpene which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM).

Linear Formula: D-Lys-(D-Lys)_n-D-Lys -+ xHBr MDL Number: MFCD00131934 Storage: −20°C

An antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO with an IC₅₀ value of 2.2 µM; sensitizes cells to apoptotic stimuli.

3-Tert-butyl-4-hydroxyanisole (3-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative and anticancer activities. In leukemia cells, 3-BHA decreases the mitochondrial membrane potential, inhibits mitochondrial oxidative…

Synonym(s): 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide; Gabazine Empirical Formula: C₁₅H₁₈BrN₃O₃ Linear Formula: C₁₅H₁₈BrN₃O₃ Formula Weight: 368.23 MDL Number: MFCD00055135…

Synonym(s): Goat IgG MDL Number: MFCD00163832 Purity: ≥95% (SDS-PAGE) Storage: 2-8°C

An inhibitor of SREBP activation, preventing SCAP-mediated escort of either SREBP-1 or SREBP-2 to the Golgi (IC₅₀ = 5.6 µM); blocks SREBP-mediated gene expression; inhibits high glucose-induced upregulation of TGF-β in primary rat mesangial cells; reduces hepatic fat…

A selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 (IC₅₀ = 22 nM).

An inhibitor of PLC-dependent processes by an undefined mechanism; inhibits platelet aggregation induced by collagen or thrombin with IC₅₀ values of 0.6 and 5 µM, respectively.

Aprotinin is a protein consisting of 58 amino acids, arranged in a single polypeptide chain that is crosslinked by three disulfide bridges. Aprotinin is found in bovine lymph nodes, lung, parotid gland, spleen, liver, pancreas, seminal vesicles, thyroid gland, kidney, mucous membranes of the…

An internal standard for the quantification of (±)-β-hydroxybutyrate (sodium salt) by GC- or LC-MS.

A selective inhibitor of 15-hydroxy PGDH (IC₅₀ = ~10 µM).

Synonyms: Actinomycin C₁; Actinomycin IV; Dactinomycin Formula: C₆₂H₈₆N₁₂O₁₆ Formula Weight: 1255.42 CAS No.: 50-76-0 Purity: ≥95% Storage Temperature: 2-8°C Application: Recommended for use in cell culture applications…

Synonym(s): L-Deoxyalliin; S-allyl-cysteine; S-allylcysteine; SAC Empirical Formula: C₆H₁₁NO₂S Linear Formula: C₆H₁₁NO₂S Formula Weight: 161.22 MDL Number: MFCD00151975 Purity: ≥98% (HPLC) Storage: 2-8°C

An antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC₅₀ = ~24 μM); 8 μM treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold, respectively; 5 mg/kg inhibits mammary…

An analytical reference standard categorized as a phytocannabinoid; intended for research and forensic applications

A semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM); has applications in breast cancer and hormone-refractory prostate cancer; intended for research applications.

Synonyms: Taurocholic-2,2,4,4-d4 acid sodium salt Molecular Formula: C26D4H40NaNO7S Molecular Weight: 541.71 Linear Structural Formula: C26D4H40NaNO7S Purity: >=98% (CP) Storage: -20C

A potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

Formula: C15H14O7 Formula weight: 306.27 CAS Number: 970-74-1 Harmonized Tariff Code:  2932.99

Synonyms: 33-epi-chloro-33-desoxyascomycin; Picrolimus Molecular Formula: C43H68ClNO11 Molecular Weight: 810.45 Linear Structural Formula: C43H68ClNO11 MDL Number: MFCD00901792 Purity: >=97% (HPLC) Storage: 2-8C Biochem Physiol Actions: Pimecrolimus, also known as…