1.0 mg
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Zearalenone
Cayman ChemicalA mycotoxin produced in food and animal feeds; activates estrogen receptors, alters hormone levels, and hasten pre-pubertal development; can cause uterine, rectal, and vaginal prolapse, abortion, and infertility in older animals.
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17-phenyl trinor Prostaglandin A2
Cayman Chemical17-phenyl trinor PGA2 is a synthetic prostaglandin analog designed for increased half-life and greater potency. There are no published reports of the biological activity of 17-phenyl trinor PGA2 in the literature at this time.
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Cannabinol
Cayman ChemicalAn analytical reference standard categorized as a phytocannabinoid; intended for research and forensic applications
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N-(2-phenylethyl)-Indomethacin amide
Cayman ChemicalN-2PIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM, respectively. It is over 400 times less potent as an inhibitor of…
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a,ß-methylene Adenosine 5'-triphosphate (sodium salt)
Cayman ChemicalA phosphonic analog of ATP and agonist of P2X1 and P2X3 (EC50 = ~1 µM); ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors; used as a stable analog of ATP to study the interaction of ATP with kinases and other proteins.
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Synonyms: N'-Formyl-N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]urea Molecular Formula: C13H15Cl3N2O3 Molecular Weight: 353.63 Linear Structural Formula: C13H15Cl3N2O3 MDL Number: MFCD28122615 Legal Information: PESTANAL is a registered trademark of Sigma-Aldrich International GmbH
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Synonym(s): Goat IgG MDL Number: MFCD00163832 Purity: ≥95% (SDS-PAGE) Storage: 2-8°C
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PF-477736
Cayman ChemicalAn ATP-competitive Chk1 inhibitor (Ki = 0.49 nM) that demonstrates 100-fold selectivity over Chk2; abrogates DNA damage-induced cell cycle arrest in tumor cell lines and xenografts, potentiating the antiproliferative effects of various chemotherapeutics.
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ML-204
Cayman ChemicalML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1,…
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11ß-Prostaglandin E2
Cayman Chemical11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM. 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2. 11β-PGE2 inhibits PGE2 binding to the…
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Darifenacin (hydrobromide)
Cayman ChemicalA receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively); effective in treating problems related to the lower urinary tract.
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"(+)-Catechin, analytical standard"
MilliporeSigmaFormula: C15H14O6 Formula Weight: 290.27 CAS No.: 154-23-4 Purity: ≥99.0% (HPLC) Storage Temperature: 2-8°C
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SMER3
Cayman ChemicalA selective inhibitor of SCFMET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response; at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4.
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Cannabidiol
Cayman ChemicalAn analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications
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DL-Glyceraldehyde-3-phosphate
Cayman ChemicalAn intermediate in several metabolic pathways, including glycolysis and gluconeogenesis.
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Synonyms: ( R , R )-3,3′-Dithiobis(2-aminopropionicacid) Formula: [-SCH2CH(NH2)CO2H]2 Formula Weight: 240.30 CAS No.: 56-89-3 Purity: 98.5-101.0% Other Notes: Tandem Mass Spectrometry data independently generated by Scripps Center…
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Piriprost (potassium salt)
Cayman ChemicalPiriprost is a structural analog of PGI2 with low IP receptor-mediated activity. Piriprost inhibits 5-LO with an IC50 value around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells. Piriprost inhibits the release of histamine and leukotrienes from isolated…
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Synonyms: 2,5-DHBA; DHB; Gentisic acid; Hydroquinonecarboxylic acid Formula: (HO)2C6H3CO2H Formula Weight: 154.12 CAS No.: 490-79-9 Purity: >99.0% (HPLC) Application: Most commonly used matrix for carbohydrates. For MALDI-MS of free…
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CGS 12066B dimaleate, 98+%
Thermo Scientific ChemicalsFormula: C17H17F3N4.2(C4H4O4) Formula weight: 566.49 Purity: 98+% CAS Number: 109028-10-6 Harmonized Tariff Code: 2933.59
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BCTC
Cayman ChemicalA potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.
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(+)-Cloprostenol methyl amide
Cayman ChemicalA more lipid soluble form of (+)-cloprostenol, possibly serving as a prodrug for the bioactive free acid.
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Pexidartinib
Cayman ChemicalA brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC50s = 20, 10, and 160 nM in vitro, respectively); blocks macrophage recruitment in mammary tumor-bearing mice and blocks glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme.
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Bortezomib
Cayman ChemicalA dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM); drives cell cycle arrest and apoptosis in cancer cell lines and has applications in multiple myeloma and certain lymphomas, as well as other types of cancer.
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Prosapogenin A phyproof(R) Reference Substance
MilliporeSigmaThis substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Synonyms: Lilioglycoside D; Ophiopogonin C';…
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VPC 23019
Cayman ChemicalA competitive antagonist of S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively); inhibits S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.
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Arbidol (hydrochloride)
Cayman ChemicalA broad-spectrum, indole-based antiviral compound that blocks viral fusion with target membranes, prohibiting viral entry into cells; effective against numerous viruses, including influenza A, B, and C and hepatitis B and C (IC50s range from 3-12.5 µg/ml).
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Synonym(s): Oleic Acid-Cyclodextrin Complex Other Notes: Methyl-β-cylodextran binding improves the solubility and delivery of Oleic acid in culture media. Storage: −20°C
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Synonyms: ( S )-2-Amino-3-(4-hydroxyphenyl)propionic acid; 3-(4-Hydroxyphenyl)-L-alanine Formula: 4-(HO)C6H4CH2CH(NH2)CO2H Formula Weight: 181.19 CAS No.: 60-18-4 Purity: ≥99.0% Other Notes: Amino acid precursor of…
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Biotin-XX hydrazide
Cayman ChemicalA biotinylating reagent that contains two aminohexanoic spacers to increase the efficiency of avidin-binding by alleviating steric hindrance.
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Puromycin Dihydrochloride
MP BiomedicalsPuromycin is an antibiotic of unique structure and biological activity. It is produced by fermentation using Streptomyces albo-niger. There are four aspects of puromycin's biological activity that are 1) antitumor effect; 2) nephrotoxic action; 3) inhibition of purine and/or protein synthesis…