The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid…

The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as integrin a4ß7, is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes but is also present on NK cells and eosinophils. The a4ß7 heterodimer mediates the binding of…

Specificity: Reacts with the heavy chain of rat IgG Source: Pooled antisera from goats hyperimmunized with rat IgG Cross Adsorption: Rat IgM; may react with immunoglobulins from other species Purification: Affinity chromatography on pooled rat IgG covalently linked to agarose Isotype: …

CD86, also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is…

Specificity: Reacts with the heavy chain of human IgG Source: Pepsin digest of Goat Anti-Human IgG (SB Cat. No. 2040) Cross Adsorption: Human IgM and IgA; may react with IgG from other species Purification: Isotype: Goat F(ab')2 IgG Format/Conjugate: FITC (Fluorescein) Buffer…

Ly-6G/Ly-6C, formerly known as the myeloid differentiation antigen Gr-1, is a GPI-anchored protein. In the bone marrow, the level of antigen expression is directly correlated with granulocyte differentiation and maturation. It is also transiently expressed on monocytes in the bone marrow. In the…

Specificity: Reacts with the heavy and light chains of rabbit IgG and the light chains of rabbit IgM Source: Pooled antisera from goats hyperimmunized with rabbit IgG Cross Adsorption: Mouse and human immunoglobulins and pooled sera; may react with immunoglobulins from other species …

Specificity: Reacts with the heavy and light chains of human IgG and the light chains of human IgM and IgA Source: Pooled antisera from goats hyperimmunized with human IgG Cross Adsorption: Mouse, bovine, and horse serum proteins (SP); may react with immunoglobulins from other species …

Specificity: Reacts with the heavy and light chains of human IgG and the light chains of human IgM and IgA Source: Pooled antisera from rabbits hyperimmunized with human IgG Cross Adsorption: None; may react with immunoglobulins from other species Purification: Affinity chromatography on…

Specificity: Reacts with mouse ? light chains Source: Pooled antisera from goats hyperimmunized with mouse ? light chains Cross Adsorption: Mouse ? light chains; may react with ? light chains from other species Purification: Affinity chromatography on mouse ? light chains covalently…

Specificity: Reacts with the heavy chain of mouse IgG2a Source: Pooled antisera from goats hyperimmunized with mouse IgG2a Cross Adsorption: Mouse IgG1, IgG2b, IgG3, IgM, and IgA; may react with immunoglobulins from other species Purification: Affinity chromatography on mouse IgG2a…

CD90 (Thy-1), a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily of cell surface receptors, consists of a single V-set domain. It is expressed on thymocytes, peripheral T lymphocytes, some intraepithelial T lymphocytes, and neurons of all mouse strains. The…

CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T lymphocytes and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. CD28 is a ligand for CD80 (B7-1) and CD86…

Specificity: Reacts with the heavy chain of mouse IgM Source: Pepsin digest of Goat Anti-Mouse IgM, Human ads (SB Cat. No. 1020) Cross Adsorption: Mouse IgG and IgA; human immunoglobulins and pooled sera; may react with immunoglobulins from other species Purification: Isotype: Goat…

Specificity: Reacts with the heavy and light chains of rat IgG and the light chains of rat IgM Source: Pepsin digest of Rabbit Anti-Rat IgG(H+L) (SB Cat. No. 6180) Cross Adsorption: None; may react with immunoglobulins from other species and the light chains of other rat immunoglobulins …

Specificity: Reacts with the heavy and light chains of chicken IgY Source: Pooled antisera from goats hyperimmunized with IgY Cross Adsorption: None; may react with immunoglobulins from other species and the light chains of other chicken immunoglobulins Purification: Affinity…

Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral…

Specificity: Reacts with the heavy chain of mouse IgG1 Source: Pepsin digest of Goat Anti-Mouse IgG1, Human ads (SB Cat. No. 1070) Cross Adsorption: Mouse IgG2a, IgG2b, IgG3, IgM, and IgA; human immunoglobulins and pooled sera; may react with immunoglobulins from other species …

The CD23 antigen is the low affinity IgE Fc receptor, which is a 45-49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells, macrophages and platelets. It is distinct from…

Ly-6C is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T-cell subsets. Mice with the Ly-6.2 allotype (e.g., AKR, C57BL, C57BR, C57L, DBA/2,…

CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage),…

CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and…

Specificity: Reacts with the heavy chain of mouse IgG2a Source: Pooled antisera from goats hyperimmunized with mouse IgG2a Cross Adsorption: Mouse IgG1, IgG2b, IgG3, IgM, and IgA; human immunoglobulins and pooled sera; may react with immunoglobulins from other species Purification: …

Specificity: Reacts with the heavy chain of mouse IgG1 Source: Pooled antisera from goats hyperimmunized with mouse IgG1 Cross Adsorption: Mouse IgG2a, IgG2b, IgG3, IgM, and IgA; human, bovine, and horse serum proteins (SP); may react with immunoglobulins from other species Purification: …

CD18 represents the common ß2 integrin subunit that associates non-covalently with the a/ß chains of CD11a, CD11b, and CD11c to form various integrin heterodimers. It is expressed strongly on lymphocytes and monocytes and weakly on granulocytes. CD18 mediates a variety of heterotypic and homotypic…

Specificity: Reacts with mouse ? light chains Source: Pooled antisera from goats hyperimmunized with mouse ? light chains Cross Adsorption: Mouse ? light chains; may react with ? light chains from other species Purification: Affinity chromatography on mouse ? light chains covalently…

Specificity: Reacts with the heavy and light chains of mouse IgG1, IgG2a, IgG2b, IgG2c, IgG3, IgM, and IgA Source: Pepsin digest of Goat Anti-Mouse Ig, Human ads (SB Cat. No. 1010) Cross Adsorption: Human immunoglobulins and pooled sera; may react with immunoglobulins from other species …

Specificity: Reacts with the heavy and light chains of mouse IgG1, IgG2a, IgG2b, IgG2c, IgG3, IgM, and IgA Source: Pooled antisera from goats hyperimmunized with mouse IgG, IgM, and IgA Cross Adsorption: Human immunoglobulins and pooled sera; may react with immunoglobulins from other species…

Specificity: Reacts with the heavy and light chains of mouse IgG1, IgG2a, IgG2b, IgG2c, and IgG3 and with the light chains of mouse IgM and IgA Source: Pooled antisera from goats hyperimmunized with mouse IgG Cross Adsorption: None; may react with immunoglobulins from other species …

CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19…

Specificity: Reacts with the heavy chain of rat IgM Source: Pooled antisera from goats hyperimmunized with rat IgM Cross Adsorption: Rat IgG; may react with immunoglobulins from other species Purification: Affinity chromatography on pooled rat IgM covalently linked to agarose Isotype: …