A selective BRD9 bromodomain inhibitor (pIC₅₀ = 7.3; pKd = 8.7); used to identify genes regulated by BRD9 in Kasumi-1 cells involved in cancer and immune response signaling.

A decomposition product of the macrolide antibiotic, erythromycin A that has been identified as a β-turn mimic of the peptide hormone motilin; used to determine the binding characteristics of ligands of the motilin receptor.

An analog of latanoprost in which the hydroxyl at C-15 is inverted relative to latanoprost; binds to the FP receptor in the cat iris sphincter muscle with an IC₅₀ value of 24 µM (tested as the free acid); potential impurity in latanoprost bulk drug preparations.

1-Hexadecyl lysophosphatidic acid is an ether analog of LPA containing a hexadecyl group at the sn-1 position. LPA binds to five different GPCRs to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.

A natural oxidative metabolic product of the mycotoxin aflatoxin B2.

An enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase.

The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent,…

Eltrombopag is a small molecule, nonpeptide agonist of the thrombopoietin receptor. It selectively binds to the transmembrane domain of the receptor and stimulates megakaryocytopoiesis in primary human bone marrow cells through the JAK/STAT signaling pathway. Eltrombopag is reported to increase…

A fatty acid amide derived from ricinoleic acid and methyl benzylamine that demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), kidney (786-0), non-small cell lung (NCI-H460), and prostate (PC-3) cancer cells with a mean GI50 value of 6.9 µM.

A selective inhibitor of JAK1 (IC₅₀ = 629 nM) that displays 30-fold selectivity for JAK1- over JAK2-dependent signaling in human whole blood; blocks IL-6/STAT1 and IL-2/STAT5 signaling in cell models and whole blood assays.

An antibiotic that suppresses the expression of ODC, COX-2, and iNOS at concentrations as low as 0.3 μM and exhibits an anti-metastasis effect and anti-tumor promoter activity in various carcinogenesis mouse models.

An inactive enantiomer of nutlin-3 that may serve as a useful control for non-MDM2 related cellular activities; also called enantiomer b based on the elution pattern during chiral separation of (±)-nutlin-3.

A small molecule inhibitor of MDMX.

The dihydro derivative of Aflatoxin B1.

A highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes; glycates and crosslinks proteins leading to the formation of advanced glycation endproducts.

A potent, reversible, and cell permeable proteasome inhibitor; a more effective inhibitor of chymotrypsin-like, trypsin-like, and peptidylglutamyl peptide hydrolyzing proteasome activities compared to (S)-MG132 (IC₅₀s = 0.22 versus 0.89 µM (ChTL); 34.4 versus 104.43 µM (TL);…

Unnatural C-15 epimer of Travoprost.

A certified reference material categorized as a phytocannabinoid; produced by the oxidocyclization of cannabigerolic acid by cannabidiolic acid synthase; intended for research and forensic applications,,

A potent and selective inhibitor of Vps34 (IC₅₀ = 25 nM in vitro); induces a rapid and pronounced loss of phosphorylation of SGK3.

A PARP1 inhibitor (IC₅₀ = 450 nM) that displays neuroprotective effects in cultured mouse cortical neurons; also inhibits eosinophilic infiltration into airways of OVA-challenged mice and induces the regression of atherosclerotic plaques in high-fat fed ApoE(-/-) mice.

A reversible, selective, allosteric antagonist of mGluR7 that blocks agonist-induced calcium mobilization (IC₅₀ = 26 nM).

17-phenyl trinor PGA2 is a synthetic prostaglandin analog designed for increased half-life and greater potency. There are no published reports of the biological activity of 17-phenyl trinor PGA2 in the literature at this time.

A 9β-hydroxy isomer of 5-trans PGF2α.

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

An inhibitor of S1P lyase; treatment of mice (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs, resulting in reversible lymphopenia.

A LPA analog containing stearyl alcohol at the sn-1 position; exhibits platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.

A specific Akt inhibitor that has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells (IC₅₀ = 30-60 nM in vitro); inhibits Akt, PDK1, and FLT3 in acute myelogenous leukemia cells, decreasing the colony-forming ability of these cells (IC₅₀…

A potent, selective inhibitor of p110δ.

An analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component; reduces IOP better than latanoprost in a rabbit model of glaucoma.

A selective autotaxin inhibitor (IC50 = 5.7 nM) that has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.

A cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 μM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 μM, respectively; does not alter HDAC1 activity.