IL-4, Interleukin-4, human: Human Interleukin-4 Interleukin-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of…

FGF-basic, Fibroblast Growth Factor-basic, rat: FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and…

NOGGIN, human: Human NOGGIN  Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for…

IFN omega, human: Interferon-Omega (IFN-ω) coded by IFNW1 gene in human, is a number of the type I interferon family, which includes IFN-α, IFN-β, and IFN-ω. The IFNAR-1/IFNAR-2 receptor complex can help with the signal transduction, followed the antiviral or the…

MIP-2, CXCL2, murine (mouse): Macrophage Inflammatory Protein 2 (MIP-2) was originally identified as a heparin binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. Based on its protein and DNA sequences, MIP-2 is a member of the alpha (CXC)…

M-CSF, murine (mouse): Macrophage Colony Stimulating Factor (M-CSF), also named CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. It is produced by osteoblasts (as a result…

The Bio Basic IL-36 Beta (153 a.a.), Murine (Mouse) is suitable for use in laboratory use only. It can be stored at a temperature of -15 to 20 degree C.

IL-1 beta, Interleukin-1 beta, porcine: Interleukin-1 beta (IL-1β) is a non-secreted proinflammatory cytokine produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and…

The Bio Basic IL-36 Beta (157 a.a.), Human is suitable for use in laboratory use only. It can be stored at a temperature of -15 to 20 degree C.

SDF-1 alpha, CXCL12, human: SDF-1α and SDF-1β, members of the chemokine α subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from…

MIP-1 beta, CCL4, rat: Chemokine (C-C motif) ligand 4 encoded by the CCL4 gene, also known as macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors and it is a major HIV-suppressive factor produced by CD8+ T cells. In addition, it is a…

IL-1 beta, InterleukinIL-1 beta, equine: Interleukin-1 beta (IL-1ß) is a non-secreted proinflammatory cytokine produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one…

IL-1 beta, Interleukin-1 beta, monkey (rhesus macaque): IL-1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not…

IFN gamma, Interferon gamma, murine (mouse): Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α…

Protein G binds to the constant region of many species of immunoglobulin G. It can be used to detect, quantify and purify IgG antibodies and antibody/antigen complexes. Bio Basic Inc’s Recombinant Protein G contains only IgG binding domains. The albumin-binding domain as well as cell wall and…

IL-1 beta, Interleukin-1 beta, human: Human Interleukin-1 beta  IL-1 beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has…

EPO, human: Human Erythropoietin Erythropoietin (EPO), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The production of EPO by kidney cells is increased in…

BD-4, rat: Defensins (alpha and beta) are cationic peptides with antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses. They are 2-6 kDa proteins and take important roles in innate immune system. On the basis of their size and pattern of…

IL-3, Interleukin-3, human: Human Interleukin-3 Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3…

EGF, Epidermal Growth Factor, human: Human Epidermal Growth Factor  EGF was originally discovered in crude preparations of nerve growth factor prepared from mouse submaxillary glands as an activity that induced early eyelid opening, incisor eruption, hair growth inhibition, and stunting…

GM-CSF, Granulocyte Macrophage Colony Stimulating Factor, murine (mouse): Mouse GM-CSF GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocytemacrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil…

BMP-4, Bone Morphogenetic Protein-4, human: Human BMP-4 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor β (TGF-β) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation.…

The Bio Basic MIP-1 Beta, CCL4, Human is suitable for use in laboratory use only. It can be stored at a temperature of -15 to 20 degree C.

GMF beta, Glia Maturation Factor beta, human: GMF-β, a brain-specific protein that belongs to the actin-binding proteins (ADF) structural family. GMF-β appears to play a role in the differentiation, maintenance, and regeneration of the nervous system. It also supports the…

IL-36 beta (183 a.a.), murine (mouse): Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through…

GMF beta, Glia Maturation Factor beta, murine (mouse): The glia maturation factor beta belongs to the actin-binding proteins ADF family, GMF subfamily. It contains an ADF-H domain, but the research of crystallography and NMR reveals that there are structures different between human and mouse…

G-CSF, murine (mouse): Granulocyte colony stimulating factor (G-CSF) is a pleiotropic cytokine. It is mainly produced by monocytes and macrophages upon activation by endotoxin, TNF-α and IFN-γ. Besides, many other cell types can secret this protein after LPS, IL-1 or TNF-α…

IL-12, Interleukin-12, human: Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. The p40 subunit of IL-12 has…

SDF-1 beta, CXCL12, rat: SDF-1α and β are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV…

sCD40 Ligand, TRAP, rHusCD40L, human: CD40 ligand, CD40L (also known as CD154, TRAP or gp39), is a 261 amino acid type II transmembrane glycoprotein belonging to the TNF family, CD40L is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, like NK cells,…

SDF-1 beta, CXCL12, murine (mouse): Mouse SDF-1beta / CXCL12 SDF-1α and SDF-1β, members of the chemokine α subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were…

TNF alpha, Tumor Necrosis Factor-alpha, human: Human Tumor Necrosis Factor-alpha Tumor necrosis factor alpha (TNF-α), also called cachectic, is produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, astrocytes endothelial cells, smooth muscle cells and some…