MIP-2, CXCL2, murine (mouse): Macrophage Inflammatory Protein 2 (MIP-2) was originally identified as a heparin binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation.
Based on its protein and DNA sequences, MIP-2 is a member of the alpha (CXC) subfamily of chemokines.
Similarly to other alpha chemokines, murine MIP-2 is a potent neutrophil attractant and activator.
MIP-2 and KC can bind the murine interleukin 8 type B receptor homologue with high affinity.
The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases., UnitProt ID: P10889