NEW! Life Science, Cayman Chemical, 25 mg
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Docosahexaenoyl Ethanolamide
Cayman ChemicalThe ethanolamine amide of DHA that has been detected in both brain and retina at concentrations similar to those for AEA; binds to the rat brain CB1 receptor (Ki = 324 nM), which is approximately 10-fold higher than the Ki for AEA; inhibits shaker-related voltage-gated potassium channels in brain…
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Vitexin
Cayman ChemicalAn apigenin flavone C-glycoside isolated from various tropical plant species that demonstrates broad antioxidant, anti-inflammatory, anticancer, and antinociceptive activities.
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Methsuximide
Cayman ChemicalA succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents; inhibits CYP2C19-mediated metabolism of biguanides; has anticonvulsant properties in clinical trials.
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EGFR Inhibitor
Cayman ChemicalA cell permeable, selective inhibitor of the EGFR kinase (IC50s = 21, 63, and 4 nM for EGFR and the L858R and L861Q EGFR mutants, respectively).
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Fialuridine
Cayman ChemicalA nucleoside analog with antiviral activity, inhibiting thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM).
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n-Triacontanol
Cayman Chemicaln-Triacontanol is a plant growth regulator found in the plant cuticle waxes and in beeswax as the palmitate ester. n-Triacontanol has been reported to have growth enhancing properties when applied to the leaves of growing plants.
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CAY10566
Cayman ChemicalA potent, selective inhibitor of Stearoyl-CoA desaturase 1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.
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DPTA NONOate
Cayman ChemicalA NO donor with a half-life of three hours at 37°C, pH 7.4; liberates two moles of NO per mole of parent compound.
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Minocycline (hydrochloride)
Cayman ChemicalA broad-spectrum tetracycline antibiotic which has a particularly long half-life in serum; commonly used in the treatment of acne in older patients; also has both anti-inflammatory and neuroprotective actions.
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HA-155
Cayman ChemicalA selective autotaxin inhibitor (IC50 = 5.7 nM) that has been shown to dose-dependently block thrombin-induced LPA secretion in platelets.
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Iopromide
Cayman ChemicalA non-ionic, water-soluble X-ray contrast agent for intravascular administration; can cause acute kidney injury and is used in animal models of contrast-induced nephropathy.
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Aldehyde Reactive Probe (trifluoroacetate salt)
Cayman ChemicalA biotinylated reagent used for the detection and quantification of apurinic/apyrimidinic (AP) sites in damaged DNA; reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, thereby covalently linking biotin to these AP sites.
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BYL719
Cayman ChemicalA selective inhibitor of PI3Kα that is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM); dose-dependently inhibits the growth of PI3Kα-dependent xenograft tumors in mice, alone or in combination with other kinase inhibitors.
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1-Hexadecyl Lysophosphatidic Acid
Cayman Chemical1-Hexadecyl lysophosphatidic acid is an ether analog of LPA containing a hexadecyl group at the sn-1 position. LPA binds to five different GPCRs to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.
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Baricitinib
Cayman ChemicalAn orally bioavailable, reversible inhibitor of JAK1 and JAK2 (IC50s = 5.9 and 5.7 nM, respectively) that has been shown to inhibit cytokine-induced phosphorylation of STAT3 in healthy human volunteers.
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N1-Acetylspermine (hydrochloride)
Cayman ChemicalA monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.
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AS-703026
Cayman ChemicalSelectively inhibits MEK1/2; potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation (IC50s = 10 and 18.2 nM, respectively); 30 mg/kg reduced tumor growth significantly in mice bearing H929 MM xenografts.
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SB-431542
Cayman ChemicalA potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM), ALK4 (IC50 = 140 nM) and, less effectively, ALK7; suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.
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Febuxostat
Cayman ChemicalA nonpurine inhibitor of xanthine oxidoreductase (Ki = 0.7 nM) that has proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
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NSC 348884
Cayman ChemicalA small molecule inhibitor of nucleophosmin dimers that can prevent cell proliferation and induce apoptosis in various cancer cell lines (IC50s = 1.4-4 µM).
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ML-097
Cayman ChemicalA small molecule pan activator of Ras-related GTPases, activating cdc42, Ras, and Rac1 with EC50 values of 102, 109, and 151 nM, respectively.
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8-hydroxy Guanine (hydrochloride)
Cayman Chemical8-hydroxy Guanine is produced by oxidative damage of DNA or RNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.
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Simvastatin (sodium salt)
Cayman ChemicalA potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM).
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BG45
Cayman ChemicalA selective inhibitor of HDAC3 (IC50 = 289 nM) that alone or in combination with bortezomib has been shown to dose-dependently inhibit tumor growth in a mouse model of multiple myeloma.
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Paclitaxel
Cayman ChemicalA potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of…
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CAY10571
Cayman ChemicalAn analog of SB203580, the highly specific pyridinylimidazole inhibitor of p38 MAPK; inhibits IL-1 production in the human monocytic cell line THP (IC50 = 0.20 µM) and binds CSAID binding protein, a serine/threonine kinase homologous to p38, inhibiting its kinase activity (IC50 = 0.03 µM).
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Cysmethynil
Cayman ChemicalAn indole-based, time-dependent inhibitor of Icmt (IC50 = i = 0.14 µM for the final complex); decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells.
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N-hexadecanoyl-L-Homoserine lactone
Cayman ChemicalOne of a number of lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum-sensing signaling in Sinorhizobium meliloti, a nitrogen-fixing bacterial symbiont of certain legumes; the most abundant AHL produced by the proteobacterium Rhodobacter…
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DMXAA
Cayman ChemicalA tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core; potently activates the STING/TBK1/IRF3 signaling pathway in mouse leukocytes, inducing type-I-IFN production; inhibits VEGFR1 and VEGFR2 (IC50 = 119 and 11…
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ML-243
Cayman ChemicalAn inhibitor of cancer stem cells, displaying 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 2.0 µM) over a control (mammary epithelial) cell line (EC50 = 64 µM).
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Gaboxadol (hydrochloride)
Cayman ChemicalA GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)); acts as an antagonist…
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A-771726
Cayman ChemicalReversibly inhibits dihyroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines, preventing DNA synthesis of activated lymphocytes (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively); also inhibits tyrosine kinases responsible for…