NEW! Life Science, Cayman Chemical
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Fluvoxamine (maleate)
Cayman ChemicalA selective serotonin reuptake inhibitor (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM); potentiates the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the CNS resulting in antidepressant effects.
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BVT 948
Cayman ChemicalA cell-permeable inhibitor of PTPs (IC50s = 0.09-1.7 µM) through oxidation of the catalytic cysteine residue; inhibits redox-sensitive CYP isoforms with IC50 values less than 10 µM; inhibits the protein methyltransferases SETD8, SETD2, G9a, SMYD2, CARM1, and PRMT3…
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Kaempferol
Cayman ChemicalA dietary flavonoid which has diverse physiological activities through both direct and indirect effects; directly binds ERα and ERβ, acting as an inverse agonist or agonist; acts as an antioxidant; suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.
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FTase Inhibitor II
Cayman ChemicalA cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras; does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM); blocks Ras-mediated transformation of NIH 3T3 cells.
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Riluzole (hydrochloride)
Cayman ChemicalA benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM); suppresses glutamate-induced seizures in rats (ED50 =…
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11-deoxy Prostaglandin E2
Cayman Chemical11-deoxy PGE2 is a stable, synthetic analog of PGE2. In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and is 5 to 30 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.
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Clopidogrel Carboxylic Acid (hydrochloride)
Cayman ChemicalA major inactive metabolite of clopidogrel that is used as a reference standard for quantitative analysis of clopidogrel metabolism.
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15(S)-HETE Ethanolamide
Cayman ChemicalLess potent than AEA (Item No. 90050) at the CB1 receptor (Ki = 600 versus 90 nM); inhibits FAAH.
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Cannabivarin
Cayman ChemicalAn analytical reference standard categorized as a phytocannabinoid; a constituent of hashish that has also been isolated from C. sativa plants; regulated as a Schedule I compound in the United States; intended for research and forensic applications
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OTSSP167 (hydrochloride)
Cayman ChemicalA potent inhibitor of MELK (IC50 = 0.41 nM); blocks the phosphorylation of MELK-specific substrates and reduces the ability of MCF-7 breast cancer cells to invade and form spheroids in Matrigel; suppresses the growth of xenograft tumors in mice.
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KB2115
Cayman ChemicalA synthetic thyroid hormone mimetic that lowers total and LDL cholesterol up to 40% when administered to humans at a dose of 50-200 µg once daily for 14 days; stimulates cholesterol catabolism to bile acids without affecting cholesterol synthesis.
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FTY720
Cayman ChemicalA structural analog of sphingosine and a novel immune modulator; inhibits lymphocyte emigration from lymphoid organs; becomes phosphorylated by sphingosine kinase in vivo to act as a potent agonist at S1P1, S1P3, S1P4, and S1P5.
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Aloe-emodin
Cayman ChemicalFunctions as a potent laxative by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle; also demonstrates anti-tumor activity (ED50s = 1-13 µM), inducing apoptosis in various cancer cells.
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Erbstatin Analog
Cayman ChemicalA stable, potent analog of erbstatin; inhibits EGFR tyrosine kinase in vitro with an IC50 of 0.14 µg/ml; inhibits EGF-stimulated growth in NIH3T3 cells with an IC50 value of 0.5 µg/ml; delays onset of EGF-induced DNA synthesis.
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Suramin (sodium salt)
Cayman ChemicalA polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ryanodine receptor-1 (IC50 = 4.9 μM), blocks G protein coupling to GPCRs, and non-selectively antagonizes P2 purinergic receptors (10-100 μM); acts as a non-specific competitor of…
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Bakuchiol
Cayman ChemicalA natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).
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cis-trismethoxy Resveratrol
Cayman ChemicalA potent anti-mitotic drug that is 100-fold more active than resveratrol at inhibiting the growth of human colon cancer Caco-2 cells; inhibits tubulin polymerization in a dose-dependent manner (IC50 = 4 μM) and enzymes involved in the synthesis of the polyamines, putrescine, and spermidine.
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PLX4720
Cayman ChemicalAn orally-available, highly selective inhibitor of B-RafV600E (IC50 = 13 nM); less effective against wild type B-Raf (IC50 = 160 nM) as well as several other kinases; induces cell cycle arrest and apoptosis in cells and xenografts expressing the mutant of B-Raf.
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Cannabigerolic Acid
Cayman ChemicalAn analytical reference material categorized as a phytocannabinoid; a precursor in the biosynthesis of tetrahydrocannabinolic acid, cannabidiolic acid, and cannabichromenic acid; intended for research and forensic applications
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Cannabidivarin (CRM)
Cayman ChemicalA certified reference material categorized as a phytocannabinoid; considered an impurity in the commercial preparations of cannabidiol; intended for research and forensic applications
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Araguspongin B
Cayman ChemicalAn antagonist of the inositol 1,4,5-trisphosphate at its carboxy terminus.
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Genipin
Cayman ChemicalA protein cross-linking agent isolated from G. jasminoides Ellis; inhibits UCP2 activity; 5 µM genipin increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose; induces apoptosis in FaO rat hepatoma cells and human…
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?8-THC (CRM)
Cayman ChemicalA certified reference material that is categorized as a phytocannabinoid; provided as a DEA exempt preparation; intended for research and forensic applications,
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(R)-(-)-Docosahexaenyl-2'-Hydroxy-1'-Propylamide
Cayman ChemicalA homolog of DHEA, characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon.
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CAY10508
Cayman ChemicalA potent and selective CB1 receptor inverse agonist (Ki = 243 nM; EC50 = 195 nM); a 10 µM concentration results in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and CB2 receptors, respectively.
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Tyramine
Cayman ChemicalA trace amine that activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively); inhibits the release of norepinephrine and dopamine (IC50s = 40.6 and 119 nM, respectively).
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Prostaglandin F2ß (tromethamine salt)
Cayman ChemicalA derivative of PGF2β with increased water solubility.
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Prostaglandin F2ß
Cayman Chemical9β-hydroxy stereoisomer of PGF2α; much less active than PGF2α in antifertility and bronchoconstrictor activities; exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α.
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SC 26196
Cayman ChemicalA selective inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to AA; orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.
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Garcinol
Cayman ChemicalAn inhibitor of the HATs p300 and pCAF (IC50 = 7 and 5 μM, respectively) that also inhibits the HAT Gcn5; promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells; induces apoptosis in several types of cancer cells and has anti-inflammatory actions.